CYP3A4, CYP3A5, and MDR1 in Human Small and Large Intestinal Cell Llines Suitable for Drug Transport Studies

Real time quantitative PCR.

1996 • 6,155 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

1989 • 2,127 citations

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1991 • 1,787 citations

Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture

1983 • 1,765 citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

FRACTURE FACES OF ZONULAE OCCLUDENTES FROM "TIGHT" AND "LEAKY" EPITHELIA

1973 • 1,086 citations

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 • 856 citations

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

1997 • 767 citations

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues.

1990 • 487 citations

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

1996 • 487 citations

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.

1987 • 475 citations

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

1990 • 402 citations

Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver.

1983 • 392 citations

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily

1994 • 390 citations

Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2

1992 • 375 citations

CYP3A gene expression in human gut epithelium

1994 • 367 citations

Dexamethasone Induces Pregnane X Receptor and Retinoid X Receptor-α Expression in Human Hepatocytes: Synergistic Increase of CYP3A4 Induction by Pregnane X Receptor Activators

2000 • 367 citations

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

1995 • 342 citations

Characterization of human small intestinal cytochromes P-450.

1999 • 332 citations

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

1991 • 326 citations

Expression of Enzymatically Active CYP3A4 by Caco-2 Cells Grown on Extracellular Matrix-Coated Permeable Supports in the Presence of 1α,25-Dihydroxyvitamin D₃

1997 • 326 citations

Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells.

1998 • 311 citations

Cytochromes P450. Metabolic and Toxicological Aspects

1997 • 261 citations

Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

1999 • 236 citations

Transport and permeability properties of human Caco-2 cells: An in vitro model of the intestinal epithelial cell barrier

1990 • 234 citations

Identification of a polymorphically expressed member of the human cytochrome P-450III family.

1989 • 224 citations

Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers.

1993 • 217 citations

Epithelial Transport of Drugs in Cell Culture. VII: Effects of Pharmaceutical Surfactant Excipients and Bile Acids on Transepithelial Permeability in Monolayers of Human Intestinal Epithelial (Caco‐2) Cells

1992 • 216 citations

Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells.

1996 • 204 citations

Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2).

2000 • 188 citations

CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells.

1996 • 143 citations

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

1995 • 141 citations

The use of human hepatocyte cultures to study the induction of cytochrome P-450.

1999 • 139 citations

Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4.

2000 • 128 citations

Characterization of the vitamin D receptor from the Caco-2 human colon carcinoma cell line: Effect of cellular differentiation

1991 • 124 citations

Separate and Interactive Regulation of Cytochrome P450 3A4 by Triiodothyronine, Dexamethasone, and Growth Hormone in Cultured Hepatocytes¹

1998 • 122 citations

Separate and Interactive Regulation of Cytochrome P450 3A4 by Triiodothyronine, Dexamethasone, and Growth Hormone in Cultured Hepatocytes

1998 • 89 citations

Vitamin D increases tight-junction conductance and paracellular Ca²⁺ transport in Caco-2 cell cultures

1998 • 87 citations

Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4.

1996 • 78 citations

First-pass midazolam metabolism catalyzed by 1alpha,25-dihydroxy vitamin D3-modified Caco-2 cell monolayers.

1999 • 68 citations

Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers.

1999 • 66 citations

Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase.

1999 • 56 citations

Expression of cytochrome P‐450 3A in HT29‐MTX cells and Caco‐2 clone TC7

1994 • 56 citations

Immunologic, functional, and morphological characterization of three new human small intestinal epithelial cell lines

1996 • 48 citations

CYP3A5 is the major cytochrome P450 3A expressed in human colon and colonic cell lines

1996 • 41 citations

Comparison of CYP3A activities in a subclone of Caco-2 cells (TC7) and human intestine.

1997 • 36 citations

Growth Hormone Stimulates, Through Tyrosine Kinase, Ion Transport and Proliferation in Human Intestinal Cells

1999 • 24 citations

Identification of a Functional Glucocorticoid Response Element in theCYP3A1/IGC2Gene

1998 • 24 citations

Comparative enantioselective pharmacokinetic studies of celiprolol in healthy volunteers and patients with impaired renal function

1990 • 14 citations