Expression of HIF-1α, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer

Targeting HIF-1 for cancer therapy

2003 • 6,321 citations

Hypoxia — a key regulatory factor in tumour growth

2002 • 4,942 citations

Revisions in the International System for Staging Lung Cancer

1997 • 4,582 citations

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

2001 • 2,558 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

2000 • 1,769 citations

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

1996 • 1,747 citations

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

2000 • 1,272 citations

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

2000 • 1,246 citations

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1996 • 1,195 citations

Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

1999 • 744 citations

Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer.

2001 • 597 citations

Prognostic Significance of Vascular Endothelial Growth Factor Protein in Node-Negative Breast Carcinoma

1997 • 503 citations

Acidic pH enhances the invasive behavior of human melanoma cells

1996 • 484 citations

Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

2001 • 467 citations

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix.

2001 • 456 citations

Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization

1998 • 446 citations

Angiostatin-converting Enzyme Activities of Human Matrilysin (MMP-7) and Gelatinase B/Type IV Collagenase (MMP-9)

1997 • 430 citations

Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes

1998 • 397 citations

HumanMN/CA9Gene, a Novel Member of the Carbonic Anhydrase Family: Structure and Exon to Protein Domain Relationships

1996 • 383 citations

Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.

2002 • 354 citations

Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer.

2001 • 338 citations

Microenvironment-induced cancer metastasis

2000 • 335 citations

Carbonic Anhydrase IX Expression, a Novel Surrogate Marker of Tumor Hypoxia, Is Associated With a Poor Prognosis in Non–Small-Cell Lung Cancer

2003 • 286 citations

Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer.

2000 • 207 citations

The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase

1998 • 206 citations

Matrix metalloproteinase 9 and the epidermal growth factor signal pathway in operable non-small cell lung cancer.

2000 • 199 citations

Carbonic Anhydrase (CA IX) Expression, a Potential New Intrinsic Marker of Hypoxia: Correlations with Tumor Oxygen Measurements and Prognosis in Locally Advanced Carcinoma of the Cervix 1

2001 • 195 citations

Prognostic impact of VEGF, CD31, CD34, and CD105 expression and tumour vessel invasion after radical surgery for IB-IIA non-small cell lung cancer

2004 • 192 citations

Detection of hypoxia in human squamous cell carcinoma by EF5 binding.

2000 • 188 citations

Tumor Oxygenation: A New Predictive Parameter in Locally Advanced Cancer of the Uterine Cervix

1993 • 184 citations

Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases

2002 • 177 citations

Tumour necrosis is an independent prognostic marker in non-small cell lung cancer: correlation with biological variables

2002 • 172 citations

Expression of vascular endothelial growth factor, hypoxia inducible factor 1α, and carbonic anhydrase IX in human tumours

2004 • 156 citations

Hypoxia‐inducible factor‐1α in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways

2004 • 151 citations

Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis

2002 • 151 citations

The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target.

1998 • 131 citations

The intratumoral expression of vascular endothelial growth factor and interleukin-8 associated with angiogenesis in nonsmall cell lung carcinoma patients

2001 • 123 citations

Thyroid-stimulating hormone promotes the secretion of vascular endothelial growth factor in thyroid cancer cell lines

1996 • 117 citations

HIF-1α, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors

2002 • 117 citations

Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas.

2003 • 116 citations

Relation of vascular endothelial growth factor production to expression and regulation of hypoxia-inducible factor-1 alpha and hypoxia-inducible factor-2 alpha in human bladder tumors and cell lines.

2001 • 99 citations

Prognostic impact of matrix metalloproteinase‐9 in operable non‐small cell lung cancer

2002 • 98 citations

Expression of hypoxia-inducible factor-1α in cervical carcinomas: correlation with tumor oxygenation

2002 • 97 citations

Treatment of Stage I Non-small Cell Lung Carcinoma*

2003 • 91 citations

DEC1 (STRA13) protein expression relates to hypoxia‐ inducible factor 1‐alpha and carbonic anhydrase‐9 overexpression in non‐small cell lung cancer

2003 • 87 citations

Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells: Involvement of cytosolic phospholipase A2 activity.

2004 • 85 citations

Carbonic Anhydrase IX in Early-Stage Non–Small Cell Lung Cancer

2004 • 84 citations

Oxygen-Mediated Regulation of Gelatinase and Tissue Inhibitor of Metalloproteinases-1 Expression by Invasive Cells

2001 • 82 citations

Correlation between cyclooxygenase-2 and tumor angiogenesis in non-small cell lung cancer

2003 • 79 citations

Prognostic significance of p53, Ki-67, VEGF and Glut-1 in resected stage I adenocarcinoma of the lung

2002 • 73 citations

Corticotropin Regulates Vascular Endothelial Growth Factor Expression in Human Fetal Adrenal Cortical Cells1

1998 • 63 citations

Morphometric evaluation of tumor matrix metalloproteinase 9 predicts survival after surgical resection of adenocarcinoma of the lung.

2003 • 55 citations

Expression of vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC): association with p53 gene mutation and prognosis

2001 • 52 citations

Treatment of Stage I Non-small Cell Lung Carcinoma<xref rid="AFF1"><sup>*</sup></xref>

2003 • 30 citations

Corticotropin Regulates Vascular Endothelial Growth Factor Expression in Human Fetal Adrenal Cortical Cells

1998 • 28 citations

Prognostic significance of p53, Ki-67, VEGF and Glut-1 in resected stage 1 adenocarcinoma of the lung

2004 • 9 citations

Deleted Work

1955 • 0 citations