Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells: Involvement of cytosolic phospholipase A2 activity.

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

1998 • 2,392 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

2000 • 1,769 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA

1991 • 1,375 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

1987 • 1,210 citations

Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization.

1995 • 1,021 citations

Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.

1998 • 887 citations

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

1997 • 792 citations

How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture.

1986 • 744 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer

1995 • 622 citations

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.

1995 • 590 citations

Increased expression of angiogenic growth factors in age-related maculopathy

1997 • 497 citations

Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases.

1995 • 425 citations

Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.

1996 • 351 citations

The Regulation of Neovascularization by Matrix Metalloproteinases and Their Inhibitors

1997 • 304 citations

Mechanisms of retinal and choroidal neovascularization.

1994 • 288 citations

The C-terminal Region of Membrane Type Matrix Metalloproteinase Is a Functional Transmembrane Domain Required for Pro-gelatinase A Activation

1995 • 269 citations

Neuropilin-1 Binds Vascular Endothelial Growth Factor 165, Placenta Growth Factor-2, and Heparin via Its b1b2 Domain

2002 • 257 citations

Expression of vascular endothelial growth factor in experimental choroidal neovascularization

1997 • 249 citations

Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in normal eyes.

1999 • 238 citations

Matrix metalloproteinases and metalloproteinase inhibitors in choroidal neovascular membranes.

1998 • 179 citations

Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia

1993 • 152 citations

Factors Controlling Ocular Angiogenesis

1997 • 138 citations

Cloning and mRNA expression of vascular endothelial growth factor in ischemic retinas of Macaca fascicularis.

1996 • 125 citations

Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species

2001 • 122 citations

Coordinate Activation of HIF-1 and NF-κB DNA Binding and COX-2 and VEGF Expression in Retinal Cells by Hypoxia

2003 • 121 citations

Matrix Metalloproteinase-9 Contributes to Choroidal Neovascularization

2002 • 118 citations

Reduced Choroidal Neovascular Membrane Formation in Matrix Metalloproteinase-2–Deficient Mice

2003 • 110 citations

Ocular neovascularization: a valuable model system

2003 • 99 citations

Coexpression of VEGF receptors VEGF-R2 and neuropilin-1 in proliferative diabetic retinopathy.

2000 • 97 citations

Clinicopathologic Correlation of Occult Choroidal Neovascularization in Age-Related Macular Degeneration

1992 • 80 citations

The recombinant catalytic domain of membrane‐type matrix metalloproteinase‐1 (MT1‐MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP‐2

1996 • 73 citations

Progesterone Withdrawal Up-Regulates Vascular Endothelial Growth Factor Receptor Type 2 in the Superficial Zone Stroma of the Human and Macaque Endometrium: Potential Relevance to Menstruation*

2000 • 69 citations

Matrix metalloproteinase (MMP) expression in experimental choroidal neovascularization

2000 • 66 citations

Platelet‐activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration

2004 • 54 citations

Corneal stimulation of MMP-1, -9 and uPA by platelet-activating factor is mediated by cyclooxygenase-2 metabolites

2001 • 52 citations

Mice without uPA, tPA, or Plasminogen Genes Are Resistant to Experimental Choroidal Neovascularization

2003 • 48 citations

Specific antigen and organelle expression of a long-term rhesus endothelial cell line

1987 • 43 citations

Platelet-activating Factor Induces the Gene Expression of TIMP-1, -2, and PAI-1: Imbalance Between the Gene Expression of MMP-9 and TIMP-1 and -2

2002 • 43 citations

Identification of the phospholipase A2 isoforms that contribute to arachidonic acid release in hypoxic endothelial cells: limits of phospholipase A2 inhibitors

2002 • 35 citations

Differences between retinal and choroidal microvascular endothelial cells (MVECs) under normal and hypoxic conditions

2003 • 27 citations

Modulation of plasminogen activator inhibitor-1 and urokinase in retinal pigmented epithelial cells.

1993 • 24 citations

Tubedown-1 in Remodeling of the Developing Vitreal Vasculature in Vivo and Regulation of Capillary Outgrowth in Vitro

2002 • 20 citations

Extravascular secretion of t-PA by the intact superfused choroid.

1995 • 15 citations

Expression of neuropilin-1 in choroidal neovascular membranes

2003 • 8 citations