Sp1 binding activity increases in activated Ito cells

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

O-glycosylation of eukaryotic transcription factors: Implications for mechanisms of transcriptional regulation

1988 • 884 citations

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

1990 • 677 citations

Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes

1992 • 577 citations

Construction of DNA sequences complementary to rat .alpha.1 and .alpha.2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D

1984 • 568 citations

Cells of the hepatic sinusoid

1998 • 557 citations

Developmental Expression of Sp1 in the Mouse

1991 • 533 citations

A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation.

1994 • 531 citations

Collagen Types in Normal and Cirrhotic Liver

1979 • 521 citations

Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism.

1991 • 437 citations

Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo.

1990 • 432 citations

Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis

1991 • 386 citations

Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan

1987 • 359 citations

Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis.

1990 • 354 citations

Book Review Ethical Problems in Dialysis and Transplantation (Developments in Nephrology. Vol. 33.) Edited by Carl M. Kjellstrand and John B. Dossetor. 235 pp., illustrated. Boston, Kluwer Academic, 1992. $108.50. 0-7923-1625-8

1993 • 329 citations

Purified Rat Liver Fat-Storing Cells in Culture Divide and Contain Collagen

1984 • 326 citations

Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo.

1991 • 320 citations

Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site.

1994 • 311 citations

Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1.

1993 • 300 citations

Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.

1994 • 300 citations

Alcoholic liver injury in baboons: transformation of lipocytes to transitional cells.

1984 • 299 citations

Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture

1992 • 288 citations

Expression of the gene of the α-smooth muscle-actin isoform in rat liver and in rat fat-storing (ITO) cells

1990 • 283 citations

In situ hybridization for procollagen types I, III and IV mRNA in normal and fibrotic rat liver: Evidence for predominant expression in nonparenchymal liver cells

1989 • 281 citations

Developmental expression of Sp1 in the mouse.

1991 • 276 citations

Alcoholic liver injury in baboons: Transformation of lipocytes to transitional cells

1984 • 275 citations

Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions.

1983 • 273 citations

Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter.

1988 • 222 citations

cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2

1993 • 203 citations

Cellular Sources of Collagen and Regulation of Collagen Production in Liver

1990 • 197 citations

Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis

1990 • 192 citations

Ito–Cell Gene Expression and Collagen Regulation

1990 • 190 citations

Differential effects of interleukin‐1α, tumor necrosis factor α, and transforming growth factor β1 on cell proliferation and collagen formation by cultured fat‐storing cells

1989 • 178 citations

Regulation of gene expression in the mouse oocyte and early preimplantation embryo: developmental changes in Sp1 and TATA box-binding protein, TBP

1994 • 178 citations

In vitro differentiation of fat-storing cells parallels marked increase of collagen synthesis and secretion

1989 • 175 citations

Regulation of Collagen Gene Expression

1989 • 171 citations

Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer.

1988 • 157 citations

The DNA‐Binding Efficiency of Sp1 is Affected by Redox Changes

1994 • 156 citations

Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo.

1994 • 154 citations

Acetaldehyde increases collagen gene transcription in cultured human fibroblasts.

1987 • 143 citations

Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture

1988 • 141 citations

DNA sequences in the first intron of the human pro-alpha 1(I) collagen gene enhance transcription.

1987 • 135 citations

Differential utilization of regulatory domains within the alpha 1(I) collagen promoter in osseous and fibroblastic cells.

1992 • 134 citations

Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter.

1991 • 131 citations

Two different negative and one positive regulatory factors interact with a short promoter segment of the alpha 1 (I) collagen gene.

1990 • 130 citations

Sp1 DNA binding efficiency is highly reduced in nuclear extracts from aged rat tissues.

1992 • 128 citations

Retinol and extracellular collagen matrices modulate hepatic Ito cell collagen phenotype and cellular retinol binding protein levels.

1987 • 127 citations

SV40 stimulates expression of the transacting factor Sp1 at the mRNA level.

1990 • 124 citations

Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene.

1989 • 121 citations

Sequential changes of extracellular matrix and proliferation of Ito cells with enhanced expression of desmin and actin in focal hepatic injury.

1986 • 108 citations

Collagen production in fat-storing cells after carbon tetrachloride intoxication in the rat. Immunoelectron microscopic observation of type I, type III collagens, and prolyl hydroxylase.

1988 • 101 citations

Transcriptional Control of the Mouse α₂(I) Collagen Gene: Functional Deletion Analysis of the Promoter and Evidence for Cell-Scific Expression

1986 • 89 citations

Differential expression of collagen types I, III, and IV by fat-storing (Ito) cells in vitro

1992 • 89 citations

Regulation of the transforming growth factor-β1 and -β3 promoters by transcription factor Spl

1993 • 87 citations

Insulinlike growth factor I and interleukin 1β messenger RNA in a rat model of granulomatous enterocolitis and hepatitis

1993 • 83 citations

?-Smooth-muscle actin expression in normal and fibrotic human livers

1993 • 80 citations

Modulation of collagen synthesis by fat-storing cells, isolated from CCl4-or vitamin A-treated rats

1987 • 76 citations

Cell-specific expression of alpha 1(I) collagen-hGH minigenes in transgenic mice.

1994 • 74 citations

NF-I/Sp1 Switch Elements Regulate Collagen α1(I) Gene Expression

1992 • 70 citations

Analysis of the collagen α(I) promoter

1989 • 64 citations

Triplex formation prevents Sp1 binding to the dihydrofolate reductase promoter.

1992 • 56 citations

Modulation of perisinusoidal cell cytoskeletal features during experimental hepatic fibrosis

1993 • 55 citations

Stimulation of the collagen α1(I) endogenous gene and transgene in carbon tetrachloride–induced hepatic fibrosis

1993 • 53 citations

Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast.

1993 • 50 citations

Collagen Production by Rat Liver Fat-Storing Cells in Primary Culture

1986 • 46 citations

DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism.

1994 • 45 citations

Transcriptional control of the mouse alpha 2(I) collagen gene: functional deletion analysis of the promoter and evidence for cell-specific expression.

1986 • 40 citations

The Effects of Hepatic Fibrosis on Ito Cell Gene Expression

1992 • 34 citations

Transcriptional control of the α 1(I) collagen gene involves orientation- and position-specific intronic sequences

1990 • 27 citations

Cleavage of Type XI Collagen Fibers by Gelatinase and by Extracts of Osteoarthritic Canine Cartilage

1991 • 19 citations