Differential utilization of regulatory domains within the alpha 1(I) collagen promoter in osseous and fibroblastic cells.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

2016 • 7,054 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria.

1983 • 1,661 citations

Assay for nanogram quantities of DNA in cellular homogenates

1979 • 923 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

High Efficiency DNA-Mediated Transformation of Primate Cells

1983 • 652 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

THE FAMILY OF COLLAGEN GENES

1990 • 511 citations

Heterologous introns can enhance expression of transgenes in mice.

1991 • 489 citations

Transcriptional repression of eukaryotic promoters

1989 • 481 citations

Biochemical Characterization with Parathormone and Calcitonin of Isolated Bone Cells: Provisional Identification of Osteoclasts and Osteoblasts

1976 • 394 citations

Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria.

1980 • 387 citations

A generic intron increases gene expression in transgenic mice.

1991 • 351 citations

Perinatal lethal osteogenesis imperfecta in transgenic mice bearing an engineered mutant pro-α1(I) collagen gene

1988 • 235 citations

The use of heparin as a simple cost-effective means of controlling background In nudeic acid hybridization procedures

1984 • 228 citations

Collagen biosynthesis during connective tissue development in chick embryo

1972 • 218 citations

Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.

1990 • 209 citations

Selective Activation of Transcription by a Novel CCAAT Binding Factor

1988 • 206 citations

Further biochemical and molecular characterization of primary rat parietal bone cell cultures

1988 • 203 citations

Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts.

1985 • 194 citations

Identification of a cell-specific transcriptional enhancer in the first intron of the mouse alpha 2 (type I) collagen gene.

1987 • 169 citations

Regulation of collagen synthesis in fetal rat calvaria by 1,25-dihydroxyvitamin D3.

1982 • 149 citations

Session I: Development, Form, and Function of Odontoblasts — CD. Torneck, Chairman

1985 • 148 citations

Isolation and characterization of the rat α1(I) collagen promoter

1989 • 145 citations

The first intron of the alpha 1(I) collagen gene contains several transcriptional regulatory elements.

1988 • 140 citations

DNA sequences in the first intron of the human pro-alpha 1(I) collagen gene enhance transcription.

1987 • 135 citations

Two different negative and one positive regulatory factors interact with a short promoter segment of the alpha 1 (I) collagen gene.

1990 • 130 citations

Parathyroid hormone alters collagen synthesis and procollagen mRNA levels in fetal rat calvaria.

1980 • 127 citations

Functional analysis of cis-acting DNA sequences controlling transcription of the human type I collagen genes.

1990 • 127 citations

Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene.

1989 • 121 citations

Regulation of a collagen gene promoter by the product of viral mos oncogene

1985 • 115 citations

A Generic Intron Increases Gene Expression in Transgenic Mice

1991 • 114 citations

Retrovirus-induced insertional mutation in Mov13 mice affects collagen I expression in a tissue-specific manner

1989 • 111 citations

Definition of essential sequences and functional equivalence of elements downstream of the adenovirus E2A and the early simian virus 40 polyadenylation sites.

1985 • 102 citations

Hormonal Regulation of Collagen Synthesis in a Clonal Rat Osteosarcoma Cell Line*

1986 • 100 citations

Complex and diversified regulatory programs control the expression of vertebrate collagen genes ¹

1990 • 100 citations

Transcriptional Control of the Mouse α₂(I) Collagen Gene: Functional Deletion Analysis of the Promoter and Evidence for Cell-Scific Expression

1986 • 89 citations

An upstream regulatory region mediates high-level, tissue-specific expression of the human alpha 1(I) collagen gene in transgenic mice.

1991 • 83 citations

Revertants of v-fos-transformed fibroblasts have mutations in cellular genes essential for transformation by other oncogenes

1987 • 82 citations

Developmental and tissue-specific expression directed by the alpha 2 type I collagen promoter in transgenic mice.

1986 • 72 citations

Differential binding of a CCAAT DNA binding factor to the promoters of the mouse alpha 2(I) and alpha 1(III) collagen genes.

1986 • 72 citations

Regulation of procollagen synthesis during the development of chick embryo calvaria. Correlation with procollagen mRNA content.

1979 • 58 citations

Maintenance of parathyroid hormone response in clonal rat osteosarcoma lines

1978 • 57 citations

Identification of a cartilage-specific promoter within intron 2 of the chick alpha 2(I) collagen gene.

1990 • 56 citations

Collagen gene expression by cultured human skin fibroblasts. Abundant steady-state levels of type VI procollagen messenger RNAs.

1989 • 55 citations

Biosynthesis of procollagen [(pro alpha 1 V)2 (pro alpha 2 V)] by chick tendon fibroblasts and procollagen (pro alpha 1 V)3 by hamster lung cell cultures.

1981 • 53 citations

Regulation of types I, III, and IV procollagen mRNA synthesis in glucocorticoid-mediated intestinal development.

1987 • 53 citations

Definition of Essential Sequences and Functional Equivalence of Elements Downstream of the Adenovirus E2A and the Early Simian Virus 40 Polyadenylation Sites

1985 • 51 citations

Regulatory Elements in the 5′-Flanking Region and the First Intron Contribute to Transcriptional Control of the Mouse Alpha 1 Type I Collagen Gene

1989 • 40 citations

Variable Effects of Dexamethasone on Protein Synthesis in Clonal Rat Osteosarcoma Cells*

1988 • 35 citations

A hepatic fibrogenic factor stimulates the synthesis of types I, III, and V procollagens in cultured cells.

1987 • 31 citations

Characterization of subpopulations of OC and OB bone cells obtained by sedimentation at unit gravity

1982 • 28 citations

An Upstream Regulatory Region Mediates High-Level, TissueSpecific Expression of the Human al(I) Collagen Gene in Transgenic Mice

1991 • 28 citations

Transcriptional control of the α 1(I) collagen gene involves orientation- and position-specific intronic sequences

1990 • 27 citations

New rat cell line that is highly susceptible to transformation by several oncogenes.

1984 • 21 citations

T cell receptor beta chain gene rearrangement shared by murine T cell lines derived from a site of autoimmune inflammation.

1988 • 9 citations

Increased expression of the gene for the proα 1(IV) chain of basement-membrane procollagen in cultured skin fibroblasts from two variants of osteogenesis imperfecta

1989 • 6 citations

New Rat Cell Line That Is Highly Susceptible to Transformation by Several Oncogenes

1984 • 5 citations