Suppressive vaccination with DNA encoding a variable region gene of the T–cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Genetic immunization is a simple method for eliciting an immune response

1992 • 1,505 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.

1994 • 599 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides

1989 • 416 citations

Anti-Idiotypic Network Induced by T Cell Vaccination Against Experimental Autoimmune Encephalomyelitis

1988 • 409 citations

DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody

1993 • 401 citations

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

1993 • 400 citations

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1996 • 389 citations

Shared Human T Cell Receptor V _β Usage to Immunodominant Regions of Myelin Basic Protein

1990 • 386 citations

MHC-Restricted Depletion of Human Myelin Basic Protein-Reactive T Cells by T Cell Vaccination

1993 • 286 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

Exposing the immunology of naked DNA vaccines

1995 • 254 citations

T cell recognition as the target for immune intervention in autoimmune disease

1989 • 218 citations

Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.

1988 • 179 citations

Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.

1988 • 172 citations

Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major.

1995 • 171 citations

Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein

1988 • 154 citations

Depletion of myelin-basic-protein autoreactive T cells by T-cell vaccination: pilot trial in multiple sclerosis

1995 • 118 citations

Fine specificity of the antibody response to myelin basic protein in the central nervous system in multiple sclerosis: the minimal B-cell epitope and a model of its features.

1995 • 111 citations

Escape from “horror autotoxicus”: Pathogenesis and treatment of autoimmune disease

1995 • 100 citations

Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic V beta 5.2 and V beta 6.1 CDR2 peptides.

1994 • 96 citations

Multiple discrete encephalitogenic epitopes of the autoantigen myelin basic protein include a determinant for I-E class II-restricted T cells.

1988 • 92 citations

Activation and Functions of CD4⁺ T‐Cell Subsets

1991 • 79 citations

Immunity to TCR peptides in multiple sclerosis. II. T cell recognition of V beta 5.2 and V beta 6.1 CDR2 peptides.

1994 • 63 citations

Major T-cell responses in multiple sclerosis

1995 • 52 citations

Direct gene transfer into mouse diaphragm

1993 • 40 citations