Approaches to Type 1 Diabetes Prevention by Intervention in Cytokine Immunoregulatory Circuits

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

T Helper Cell Subsets in Insulin-Dependent Diabetes

1995 • 600 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

1996 • 581 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.

1993 • 510 citations

Th1 And Th2 Cells: Different Patterns Of Lymphokine Secretion Lead To Different Functional Properties

1989 • 460 citations

Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein.

1990 • 454 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.

1996 • 428 citations

Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes.

1997 • 349 citations

A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

1994 • 347 citations

Interleukin‐4 and interleukin‐10 synergize to inhibit cell‐mediated immunity in vivo

1993 • 341 citations

Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice.

1996 • 311 citations

CD28 costimulation promotes the production of Th2 cytokines.

1997 • 299 citations

The Role of Macrophages in T Cell–mediated Autoimmune Diabetes in Nonobese Diabetic Mice

1999 • 279 citations

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes

1993 • 247 citations

CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice.

1997 • 244 citations

Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats.

1987 • 224 citations

HOW DO MONOCLONAL ANTIBODIES INDUCE TOLERANCE? A Role for Infectious Tolerance?

1998 • 223 citations

Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide

1984 • 220 citations

Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation

1993 • 211 citations

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

2001 • 210 citations

IL-2 knockout recipient mice reject islet cell allografts.

1995 • 204 citations

Anti‐suppressor effect of cyclophosphamide on the development of spontaneous diabetes in nod mice

1988 • 199 citations

Differential ability of T cell subsets to undergo activation-induced cell death

1997 • 188 citations

Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans.

1993 • 183 citations

Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance

1997 • 180 citations

Impaired Alloantigen-Mediated T Cell Apoptosis and Failure To Induce Long-Term Allograft Survival in IL-2-Deficient Mice

1998 • 178 citations

Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese diabetic mice

1997 • 178 citations

Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice.

1993 • 176 citations

Roles of multiple accessory molecules in T-cell activation

1991 • 167 citations

Altered Cytokine Activity in Adjuvant Inhibition of Autoimmune Diabetes

1993 • 151 citations

Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice.

1998 • 149 citations

Persistent MHV (mouse hepatitis virus) infection reduces the incidence of diabetes mellitus in non-obese diabetic mice

1991 • 147 citations

Impaired Yield, Phenotype, and Function of Monocyte-Derived Dendritic Cells in Humans at Risk for Insulin-Dependent Diabetes

1998 • 140 citations

A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice.

1997 • 138 citations

Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice

1994 • 138 citations

Oral Administration of Human Insulin to NOD Mice Generates CD4+ T Cells that Suppress Adoptive Transfer of Diabetes

1994 • 137 citations

Prevention of diabetes in nonobese diabetic mice by anti-I-A monoclonal antibodies: transfer of protection by splenic T cells.

1988 • 130 citations

Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning

1989 • 122 citations

Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?

1994 • 112 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 109 citations

Insulin-dependent diabetes mellitus as an autoimmune disease

1994 • 103 citations

B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice

1997 • 101 citations

A New Type of CD4+ Suppressor T cell Completely Prevents Spontaneous Autoimmune Diabetes and Recurrent Diabetes in Syngeneic Islet-Transplanted NOD Mice

1996 • 96 citations

Acquisition of Lymphokine-Producing Phenotype By CD4+ T Cells

1994 • 91 citations

Suppression of development of diabetes in NOD mice by lactate dehydrogenase virus infection

1992 • 87 citations

Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism.

1997 • 85 citations

Detection and measurement of cytokines

1992 • 85 citations

Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.

1984 • 84 citations

Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant

1990 • 79 citations

COMBINED THERAPY WITH INTERLEUKIN-4 AND INTERLEUKIN-10 INHIBITS AUTOIMMUNE DIABETES RECURRENCE IN SYNGENEIC ISLET-TRANSPLANTED NONOBESE DIABETIC MICE ANALYSIS OF CYTOKINE MRNA EXPRESSION IN THE GRAFT

1995 • 75 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1994 • 75 citations

Inhibition of diabetes in BB rats by virus infection.

1988 • 72 citations

Induction of tolerance in murine autoimmune diabetes by transient blockade of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 pathway.

1996 • 72 citations

Administration of silica prevents diabetes in BB-rats

1985 • 70 citations

Prevention of diabetes in NOD mice by a mutated I-Ab transgene.

1998 • 67 citations

Prevention of insulitis and diabetes onset by treatment with complete Freund's adjuvant in NOD mice

1991 • 67 citations

Influence of Microbial Agents on the Development and Prevention of Autoimmune Diabetes

1993 • 58 citations

A T-cell dormant state in the autoimmune process of nonobese diabetic mice treated with complete Freund's adjuvant.

1992 • 57 citations

Evidence of CD4 + regulatory T cells in the non-obese diabetic male mouse

1994 • 55 citations

An immunomodulating protein, Ling Zhi-8 (LZ-8) prevents insulitis in non-obese diabetic mice

1990 • 52 citations

Islet‐infiltrating T cell clones from non‐obese diabetic mice that promote or prevent accelerated onset diabetes

1991 • 49 citations

Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice.

2000 • 49 citations

Mhc Class-Ii Molecules And Autoimmunity

1991 • 42 citations

Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB rats

1989 • 40 citations

Soluble forms of intercellular adhesion molecule-1 inhibit insulitis and onset of autoimmune diabetes

1998 • 40 citations

Preferential infiltration of macrophages during early stages of insulitis in diabetes-prone BB rats

1988 • 35 citations

The Primary Lesion Theory of Autoimmunity: A Speculative Hypothesis

1990 • 35 citations

BCG IMMUNOTHERAPY PREVENTS RECURRENCE OF DIABETES IN ISLET GRAFTS TRANSPLANTED INTO SPONTANEOUSLY DIABETIC NOD MICE

1994 • 35 citations

Protection from autoimmune diabetes by adjuvant therapy non-obese diabetic mouse: The role of interleukin-4 and interleukin-10

1997 • 31 citations

Tolerance Induction as a Therapeutic Strategy for the Control of Autoimmune Endocrine Disease in Mouse Models

1995 • 30 citations

Prevention of recurrence of IDDM in islet-transplanted diabetic NOD mice by adjuvant immunotherapy

1992 • 28 citations

Transfer of Type 1 (insulin-dependent) diabetes mellitus associated autoimmunity to mice with severe combined immunodeficiency (SCID)

1993 • 27 citations

Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse

1997 • 24 citations

Expression of intercellular adhesion molecule 1 on pancreatic beta-cells accelerates beta-cell destruction by cytotoxic T-cells in murine autoimmune diabetes

1995 • 24 citations

Interleukin-4 deficiency does not exacerbate disease in NOD mice

1998 • 22 citations

An anergic, islet-infiltrating T-cell clone that suppresses murine diabetes secretes a factor that blocks interleukin 2/interleukin 4-dependent proliferation.

1992 • 19 citations

Protection against autoimmune diabetes with oral insulin is associated with the presence of IL-4 type 2 T-cells in the pancreas and pancreatic lymph nodes

1998 • 17 citations

Mechanisms Of Complete Freund's Adjuvant Protection Against Diabetes in Bb Rats: Induction Of Non-Specific Suppressor Cells

1992 • 14 citations

Treatment with streptococcal preparation (OK-432) suppresses anti-islet autoimmunity and prevents diabetes in BB rats

1988 • 10 citations

Studies of concanavalin A in nonobese diabetic mice. I. Prevention of insulin-dependent diabetes.

1991 • 9 citations

Differential Regulation of Murine T Lymphocyte Subsets

1993 • 6 citations

Analysis of cytokine mRNA expression in syngeneic islet grafts of NOD mice: interleukin 2 and interferon gamma mRNA expression correlate with graft rejection and interleukin 10 with graft survival

1994 • 4 citations