Matrix Metalloproteinase-Mediated Disruption of Tight Junction Proteins in Cerebral Vessels is Reversed by Synthetic Matrix Metalloproteinase Inhibitor in Focal Ischemia in Rat

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

The Blood-Brain Barrier/Neurovascular Unit in Health and Disease

2005 • 2,454 citations

Multifunctional strands in tight junctions

2001 • 2,392 citations

The blood–brain barrier: an overview

2004 • 2,040 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

2003 • 1,705 citations

Mechanisms, challenges and opportunities in stroke

2003 • 1,688 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis

2004 • 1,255 citations

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

1999 • 1,100 citations

Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia

2001 • 982 citations

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

1998 • 847 citations

Endothelial Claudin

1999 • 802 citations

Matrix Metalloproteinase Expression Increases After Cerebral Focal Ischemia in Rats

1998 • 731 citations

Matrix Metalloproteinases Increase Very Early during Experimental Focal Cerebral Ischemia

1999 • 548 citations

Pores in the Wall

2000 • 451 citations

Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat

1996 • 408 citations

Early Appearance of Activated Matrix Metalloproteinase-9 after Focal Cerebral Ischemia in Mice: A Possible Role in Blood—Brain Barrier Dysfunction

1999 • 403 citations

Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures

2001 • 382 citations

Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation

2002 • 375 citations

Microvascular Basal Lamina Antigens Disappear During Cerebral Ischemia and Reperfusion

1995 • 369 citations

Activation of a recombinant membrane type 1‐matrix metalloproteinase (MT1‐MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)‐2

1996 • 358 citations

The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion

1985 • 354 citations

Metalloproteinase Inhibition Reduces Thrombolytic (Tissue Plasminogen Activator)–Induced Hemorrhage After Thromboembolic Stroke

2000 • 337 citations

Regulation of Tight Junction Permeability and Occludin Phosphorylation by RhoA-p160ROCK-dependent and -independent Mechanisms

2001 • 300 citations

Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood–retinal barrier

2005 • 298 citations

Matrix Metalloproteinase-9 Knockout Confers Resistance to Corneal Epithelial Barrier Disruption in Experimental Dry Eye

2005 • 295 citations

Molecular mechanisms of brain tumor edema

2004 • 284 citations

Closure of the Blood-Brain Barrier by Matrix Metalloproteinase Inhibition Reduces rtPA-Mediated Mortality in Cerebral Ischemia With Delayed Reperfusion

2003 • 265 citations

Focal Cerebral Ischemia Induces Active Proteases That Degrade Microvascular Matrix

2004 • 265 citations

Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression

2001 • 259 citations

Claudin Promotes Activation of Pro-matrix Metalloproteinase-2 Mediated by Membrane-type Matrix Metalloproteinases

2001 • 218 citations

Correlation of tight junction morphology with the expression of tight junction proteins in blood-brain barrier endothelial cells

2000 • 197 citations

Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression

2003 • 189 citations

Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition

1999 • 171 citations

Gelatinase B and TIMP‐1 are regulated in a cell‐ and time‐dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia

2002 • 149 citations

Reciprocal Regulation of the Junctional Proteins Claudin-1 and Connexin43 by Interleukin-1β in Primary Human Fetal Astrocytes

2000 • 139 citations

Activation Systems for Latent Matrix Metalloproteinase-2 are Upregulated Immediately after Focal Cerebral Ischemia

2003 • 133 citations

Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood–brain barrier endothelial cells

2000 • 121 citations

Metabolic Mapping of Proteinase Activity with Emphasis on In Situ Zymography of Gelatinases

2004 • 118 citations

Endothelial cell–astrocyte interactions and TGFβ are required for induction of blood–neural barrier properties

2004 • 116 citations

Reversible disruption of tight junction complexes in the rat blood‐brain barrier, following transitory focal astrocyte loss

2004 • 115 citations

Tyrosine phosphatase inhibition induces loss of blood–brain barrier integrity by matrix metalloproteinase-dependent and -independent pathways

2003 • 96 citations

Hypoxia-induced changes in tight junction permeability of brain capillary endothelial cells are associated with IL-1beta and nitric oxide

2004 • 71 citations

Estimation of Gelatinase Content in Rat Brain: Effect of Focal Ischemia

2000 • 38 citations