Closure of the Blood-Brain Barrier by Matrix Metalloproteinase Inhibition Reduces rtPA-Mediated Mortality in Cerebral Ischemia With Delayed Reperfusion

Tissue Plasminogen Activator for Acute Ischemic Stroke

1995 • 10,997 citations

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Matrix Metalloproteinases: Biologic Activity and Clinical Implications

2000 • 1,533 citations

Metalloproteinases in biology and pathology of the nervous system

2001 • 1,032 citations

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

1998 • 847 citations

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling

2001 • 696 citations

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

1997 • 664 citations

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

1995 • 659 citations

Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

1998 • 629 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

1981 • 587 citations

Involvement of Matrix Metalloproteinase in Thrombolysis-Associated Hemorrhagic Transformation After Embolic Focal Ischemia in Rats

2002 • 412 citations

Metalloproteinase Inhibition Reduces Thrombolytic (Tissue Plasminogen Activator)–Induced Hemorrhage After Thromboembolic Stroke

2000 • 337 citations

Studies on the Specific Fibrinolytic Effect of Human Extrinsic (Tissue-Type) Plasminogen Activator in Human Blood and in Various Animal Species in Vitro

1981 • 231 citations

Blood-Brain Barrier Disruption and Matrix Metalloproteinase-9 Expression During Reperfusion Injury

2002 • 205 citations

Use of a Spectrophotometric Hemoglobin Assay to Objectively Quantify Intracerebral Hemorrhage in Mice

1997 • 196 citations

Microvascular Basal Lamina Injury after Experimental Focal Cerebral Ischemia and Reperfusion in the Rat

2002 • 121 citations

Zymographic measurement of gelatinase activity in brain tissue after detergent extraction and affinity-support purification

1997 • 117 citations

Injury-induced 92-kilodalton gelatinase and urokinase expression in rat brain.

1994 • 115 citations

Rapid Breakdown of Microvascular Barriers and Subsequent Hemorrhagic Transformation After Delayed Recombinant Tissue Plasminogen Activator Treatment in a Rat Embolic Stroke Model

2002 • 99 citations

Thrombolysis With Tissue Plasminogen Activator Alters Adhesion Molecule Expression in the Ischemic Rat Brain

1999 • 88 citations

Regulation of Gelatinase Activity in Mice with Targeted Inactivation of Components of the Plasminogen/Plasmin System

1998 • 86 citations

Synthetic Inhibitors of Matrix Metalloproteinases

1998 • 64 citations

Effects of Tissue Type Plasminogen Activator in Embolic versus Mechanical Models of Focal Cerebral Ischemia in Rats

1999 • 60 citations

Plasmin Promotes an Endothelium-Dependent Adhesion of Neutrophils

1996 • 58 citations

Delayed rt-PA Treatment in a Rat Embolic Stroke Model: Diagnosis and Prognosis of Ischemic Injury and Hemorrhagic Transformation with Magnetic Resonance Imaging

2001 • 58 citations

Tissue plasminogen activator does not increase neuronal damage in rat models of global and focal ischemia

1999 • 47 citations