ER stress signaling by regulated splicing: IRE1/HAC1/XBP1

Antibodies, a laboratory manual

1989 • 12,929 citations

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Antibodies: A laboratory manual

1989 • 4,532 citations

A membrane-filter technique for the detection of complementary DNA

1966 • 3,996 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

[1] Getting started with yeast

1991 • 2,456 citations

Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

1977 • 2,408 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates

1987 • 2,098 citations

Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds

1995 • 1,943 citations

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

2000 • 1,939 citations

Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway

1980 • 1,808 citations

Multifunctional yeast high-copy-number shuttle vectors

1992 • 1,656 citations

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.

1996 • 1,306 citations

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

1988 • 1,292 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins

1998 • 1,216 citations

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1993 • 1,197 citations

Orchestrating the unfolded protein response in health and disease

2002 • 1,163 citations

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

2002 • 1,031 citations

A Novel Mechanism for Regulating Activity of a Transcription Factor That Controls the Unfolded Protein Response

1996 • 1,017 citations

Orchestrating the unfolded protein response in health and disease

2002 • 966 citations

Tripartite Management of Unfolded Proteins in the Endoplasmic Reticulum

2000 • 917 citations

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1998 • 888 citations

The Transmembrane Kinase Ire1p Is a Site-Specific Endonuclease That Initiates mRNA Splicing in the Unfolded Protein Response

1997 • 886 citations

A transmembrane protein with a cdc2+CDC28-related kinase activity is required for signaling from the ER to the nucleus

1993 • 814 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

2001 • 772 citations

Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development

2001 • 693 citations

A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response

2003 • 670 citations

Purification, Composition, and Molecular Weight of the β-Galactosidase of Escherichia coli K12

1965 • 660 citations

TUNICAMYCIN, A NEW ANTIBIOTIC. I

1971 • 535 citations

Role of EDEM in the Release of Misfolded Glycoproteins from the Calnexin Cycle

2003 • 464 citations

A regulatory link between ER-associated protein degradation and the unfolded-protein response.

2000 • 459 citations

A novel ER α‐mannosidase‐like protein accelerates ER‐associated degradation

2001 • 459 citations

Inhibition of the sarcoplasmic reticulum Ca2+ transport ATPase by thapsigargin at subnanomolar concentrations

1991 • 452 citations

A transgenic mouse model for monitoring endoplasmic reticulum stress

2003 • 452 citations

EDEM As an Acceptor of Terminally Misfolded Glycoproteins Released from Calnexin

2003 • 446 citations

tRNA Ligase Is Required for Regulated mRNA Splicing in the Unfolded Protein Response

1996 • 440 citations

Biochemical characterization of the mammalian stress proteins and identification of two stress proteins as glucose- and Ca2+-ionophore-regulated proteins.

1983 • 431 citations

Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase

1979 • 411 citations

The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane.

1997 • 408 citations

Increased sensitivity to dextran sodium sulfate colitis in IRE1β-deficient mice

2001 • 390 citations

Synthesis, processing, and secretion of recombinant human factor VIII expressed in mammalian cells.

1988 • 385 citations

INTRACELLULAR TRANSPORT OF SECRETORY PROTEINS IN THE PANCREATIC EXOCRINE CELL

1968 • 376 citations

A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.

1992 • 375 citations

Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic‐leucine zipper motif is required for the unfolded protein‐response pathway

1996 • 363 citations

The specific site of tunicamycin inhibition in the formation of dolichol‐bound N‐acetylglucosamine derivatives

1976 • 362 citations

Block of HAC1 mRNA Translation by Long-Range Base Pairing Is Released by Cytoplasmic Splicing upon Induction of the Unfolded Protein Response

2001 • 328 citations

The Promoter Region of the Yeast KAR2 (BiP) Gene Contains a Regulatory Domain that Responds to the Presence of Unfolded Proteins in the Endoplasmic Reticulum

1993 • 328 citations

Dissociation of Kar2p/BiP from an ER Sensory Molecule, Ire1p, Triggers the Unfolded Protein Response in Yeast

2000 • 302 citations

Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress

2001 • 299 citations

Tunicamycin — An inhibitor of yeast glycoprotein synthesis

1974 • 289 citations

Role of ATP and disulphide bonds during protein folding in the endoplasmic reticulum

1992 • 286 citations

Endoplasmic Reticulum Stress-induced mRNA Splicing Permits Synthesis of Transcription Factor Hac1p/Ern4p That Activates the Unfolded Protein Response

1997 • 283 citations

A Role for Presenilin-1 in Nuclear Accumulation of Ire1 Fragments and Induction of the Mammalian Unfolded Protein Response

1999 • 281 citations

The X‐box binding protein‐1 transcription factor is required for plasma cell differentiation and the unfolded protein response

2003 • 265 citations

Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cells

1989 • 261 citations

The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

2000 • 260 citations

IRE1 and efferent signaling from the endoplasmic reticulum

2000 • 259 citations

The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum.

1993 • 246 citations

The glucanase‐soluble mannoproteins limit cell wall porosity in Saccharomyces cerevisiae

1990 • 239 citations

Bypassing a Kinase Activity with an ATP-Competitive Drug

2003 • 234 citations

Inhibition of biosynthesis of polyisoprenol sugars in chick embryo microsomes by tunicamycin.

1975 • 230 citations

Relationship of the structure and biological activity of the natural homologues of tunicamycin.

1982 • 225 citations

Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway

1999 • 223 citations

Genetic Evidence for a Role of BiP/Kar2 That Regulates Ire1 in Response to Accumulation of Unfolded Proteins

2003 • 208 citations

Biological activities of the two major components of tunicamycin.

1979 • 204 citations

RNA Methodologies: A Laboratory Guide for Isolation and Characterization

2009 • 185 citations

EFFECT OF TUNICAMYCIN ON THE SYNTHESIS OF MACROMOLECULES IN CULTURES OF CHICK EMBRYO FIBROBLASTS INFECTED WITH NEWCASTLE DISEASE VIRUS

1971 • 185 citations

Degradation of Proteins from the ER of S. cerevisiae Requires an Intact Unfolded Protein Response Pathway

2000 • 185 citations

Translational attenuation mediated by an mRNA intron

1997 • 183 citations

mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response

2000 • 181 citations

The Unfolded Protein Response Pathway in

1996 • 180 citations

Lysis of Yeast Cell Walls Induced by 2-Deoxyglucose at Their Sites of Glucan Synthesis

1968 • 164 citations

The yeast SEC53 gene encodes phosphomannomutase.

1988 • 155 citations

Solubilzation in formamide protects RNA from degradation

1992 • 149 citations

Biochemical characterization of the 94- and 78-kilodalton glucose-regulated proteins in hamster fibroblasts.

1984 • 148 citations

Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levels.

1990 • 147 citations

Palindrome with Spacer of One Nucleotide Is Characteristic of the cis-Acting Unfolded Protein Response Element inSaccharomyces cerevisiae

1998 • 146 citations

Calcium ionophore A23187 induces expression of glucose-regulated genes and their heterologous fusion genes.

1985 • 146 citations

The Effects of 2-Deoxyglucose on the Growth and Metabolism of Cultured Human Cells

1961 • 135 citations

Induction of an antioxidant protein of Saccharomyces cerevisiae by O2, Fe3+, or 2-mercaptoethanol.

1989 • 134 citations

Steady-state free Ca2+ in the yeast endoplasmic reticulum reaches only 10 microM and is mainly controlled by the secretory pathway pump Pmr1

1999 • 134 citations

Yeast secretory mutants that block the formation of active cell surface enzymes.

1984 • 131 citations

Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression

1996 • 119 citations

Changes in surface properties of normal and transformed cells caused by tunicamycin, an inhibitor of protein glycosylation.

1977 • 117 citations

N-Acetylglucosamine-1-phosphate transferase from hen oviduct: solubilization, characterization, and inhibition by tunicamycin

1979 • 114 citations

Asparagine-linked glycosylation in Saccharomyces cerevisiae: genetic analysis of an early step.

1984 • 113 citations

RNA methodologies: a laboratory guide for isolation and characterization

1993 • 104 citations

The SPS100 gene of Saccharomyces cerevisiae is activated late in the sporulation process and contributes to spore wall maturation.

1988 • 100 citations

The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast

2000 • 95 citations

Invertase and Disulphide Bridges in the Yeast Wall

1970 • 94 citations

Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts

2004 • 90 citations

The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum.

1993 • 90 citations

Selective stimulation of the synthesis of an 80,000-dalton protein by calcium ionophores.

1981 • 88 citations

Genes required for completion of import of proteins into the endoplasmic reticulum in yeast.

1984 • 86 citations

Reconstitution of GTP-binding Sar1 protein function in ER to Golgi transport.

1991 • 84 citations

TUNICAMYCIN, A NEW ANTIBIOTIC. II

1971 • 81 citations

Saccharomyces cerevisiae structural cell wall mannoprotein

1985 • 80 citations

Mechanism of 2‐Deoxy‐<scp>d</scp>‐glucose Inhibition of Cell‐Wall Polysaccharide and Glycoprotein Biosyntheses in Saccharomyces cerevisiae

1975 • 79 citations

One-Hour Downward Capillary Blotting of RNA at Neutral pH

1994 • 78 citations

RNA methodologies: a laboratory manual for isolation and characterization.

1993 • 77 citations

Product of SEC53 is required for folding and glycosylation of secretory proteins in the lumen of the yeast endoplasmic reticulum.

1987 • 73 citations

Hac1: A novel yeast bZIP protein binding to the CRE motif is a multicopy suppressor for cdcW mutant of Schizosaccharomyces pombe

1994 • 72 citations

The Levels of Endoplasmic Reticulum Proteins and ATP Affect Folding and Secretion of Selective Proteins

1994 • 72 citations

An obligatory role of protein glycosylation in the life cycle of yeast cells

1982 • 71 citations

Characterization of two homologs of Ire1p, a kinase/endoribonuclease in yeast, in Arabidopsis thaliana

2002 • 67 citations

Isolation and Characterization of a Putative Transducer of Endoplasmic Reticulum Stress in Oryza sativa

2002 • 65 citations

Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p

1997 • 63 citations

Characterization of phosphatidylserine synthase from saccharomyces cerevisiae and a mutant defective in the enzyme

1981 • 59 citations

Inducible Membranes in Yeast: Relation to the Unfolded-Protein-Response Pathway

1997 • 56 citations

A hybrid protein kinase‐RNase in an interferon‐induced pathway?

1993 • 53 citations

IRE1‐ and HAC1‐independent transcriptional regulation in the unfolded protein response of yeast

2003 • 52 citations

Factors Enhancing Genetic Transformation of Intact Yeast Cells Modify Cell Wall Porosity

1986 • 52 citations

Possible cross-regulation of phosphate and sulfate metabolism in Saccharomyces cerevisiae.

1992 • 49 citations

Inhibition of lipid-linked saccharide synthesis: Comparison of tunicamycin, streptovirudin, and antibiotic 24010

1979 • 48 citations

Accumulation of Misfolded Protein Aggregates Leads to the Formation of Russell Body-like Dilated Endoplasmic Reticulum in Yeast

1997 • 48 citations

Interference of Nucleoside Diphosphate Derivatives of 2-Deoxy-d-glucose with the Glycosylation of Virus-Specific Glycoproteins in vivo

1976 • 45 citations

Glycosylation in vitro of Semliki‐Forest‐Virus and Influenza‐Virus Glycoproteins and Its Suppression by Nucleotide‐2‐deoxy‐hexose

1978 • 44 citations

The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase

2004 • 43 citations

Inhibitory Effect of 2-Deoxy- <scp>d</scp> -Glucose on the Formation of the Cell Wall in Yeast Protoplasts

1969 • 43 citations

Separation of tunicamycin homologues by reversed-phase high-performance liquid chromatography

1980 • 42 citations

Induction of protein aggregation in an early secretory compartment by elevation of expression level

2002 • 41 citations

Thiol induced release of invertase from cell walls of Saccharomyces fragilis

1970 • 41 citations

EFFECT OF TUNICAMYCIN ON MICROORGANISMS: MORPHOLOGICAL CHANGES AND DEGRADATION OF RNA AND DNA INDUCED BY TUNICAMYCIN

1972 • 39 citations

Metabolism of 2-deoxy-d-glucose in baker's yeast

1969 • 38 citations

Novel activity of a yeast ligase deletion polypeptide. Evidence for GTP-dependent tRNA splicing.

1993 • 37 citations

Effect of tunicamycin on cell cycle progression in budding yeast

1987 • 36 citations

Deoxyglucose inhibition of protein glycosylation: Effects of nucleotide deoxysugars on the formation of glucosylated lipid intermediates

1981 • 30 citations

Null Mutation in IRE1 Gene Inhibits Overproduction of Microsomal Cytochrome P450Alkl (CYP 52A3) and Proliferation of the Endoplasmic Reticulum in Saccharomyces cerevisiae

1999 • 26 citations

Unfolded protein response-induced BiP/Kar2p production protects cell growth against accumulation of misfolded protein aggregates in the yeast endoplasmic reticulum

1999 • 25 citations

Effect of thiol reagents on extractability of protein from yeast

1978 • 23 citations

Multiple nucleotide cofactor use by yeast ligase in tRNA splicing. Evidence for independent ATP- and GTP-binding sites.

1993 • 22 citations

REGULATION OF MEMBRANE ASSEMBLY DURING DEVELOPMENT OF SARCOPLASMIC RETICULUM: THE POSSIBLE ROLE OF CALCIUM*

1982 • 22 citations

Mercaptoethanol and dithiothreitol decrease the difference of electrochemical proton potentials across the yeast plasma and vacuoar membranes and activate their H⁺‐ATPases

1992 • 18 citations

Ire1p: A Kinase and Site-Specific Endoribonuclease

2003 • 16 citations

Misfolded Membrane-Bound Cytochrome P450 Activates KAR2 Induction through Two Distinct Mechanisms

1999 • 14 citations

Tunicamycin inhibition of epispore formation in Saccharomyces cerevisiae

1987 • 10 citations

The effect of thiols onSaccharomyces fragilis

1975 • 10 citations

Purification and Activity Assays of the Catalytic Domains of the Kinase/Endoribonuclease Ire1p from Saccharomyces cerevisiae

2001 • 9 citations

Role of glycosylation in the incorporation of intrinsic mannoproteins into cell walls of Saccharomyces cerevisiae

1989 • 8 citations

On the Modification of Adenosine Kinase by Thiols

1978 • 7 citations