Induction of protein aggregation in an early secretory compartment by elevation of expression level

Current protocols in molecular biology

1988 • 7,584 citations

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

Protein folding in the cell

1992 • 4,138 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.

1980 • 903 citations

Protein disulphide isomerase: building bridges in protein folding

1994 • 718 citations

[16] Isolation of subcellular organelles

1990 • 563 citations

Association of folding intermediates of glycoproteins with calnexin during protein maturation

1993 • 558 citations

The rate of bulk flow from the endoplasmic reticulum to the cell surface

1987 • 542 citations

VITAMIN K-DEPENDENT CARBOXYLASE

1985 • 466 citations

Protein disulfide isomerase: Multiple roles in the modification of nascent secretory proteins

1989 • 466 citations

Mutations in the ER–Golgi Intermediate Compartment Protein ERGIC-53 Cause Combined Deficiency of Coagulation Factors V and VIII

1998 • 461 citations

A regulatory link between ER-associated protein degradation and the unfolded-protein response.

2000 • 459 citations

Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus.

1994 • 447 citations

Protein Aggregation in vitro and in vivo: A Quantitative Model of the Kinetic Competition between Folding and Aggregation

1991 • 440 citations

Synthesis, processing, and secretion of recombinant human factor VIII expressed in mammalian cells.

1988 • 385 citations

Glycosidases of the asparagine-linked oligosaccharide processing pathway

1994 • 330 citations

The lectin ERGIC-53 is a cargo transport receptor for glycoproteins

1999 • 328 citations

Interactions of misfolded influenza virus hemagglutinin with binding protein (BiP).

1989 • 312 citations

Role of ATP and disulphide bonds during protein folding in the endoplasmic reticulum

1992 • 286 citations

The Size and Shape of Human and Bovine Antithrombin III

1977 • 264 citations

The nonglycosylated glycoprotein of vesicular stomatitis virus is temperature-sensitive and undergoes intracellular aggregation at elevated temperatures.

1979 • 255 citations

High Level Expression of Tissue Inhibitor of Metalloproteinases in Chinese Hamster Ovary Cells Using Glutamine Synthetase Gene Amplification

1990 • 249 citations

Expression, purification, and characterization of recombinant gamma-carboxylated factor IX synthesized in Chinese hamster ovary cells.

1986 • 228 citations

Heavy chain binding protein recognizes incompletely disulfide-bonded forms of vesicular stomatitis virus G protein.

1990 • 180 citations

Misfolding and aggregation of newly synthesized proteins in the endoplasmic reticulum.

1992 • 177 citations

The physiological inhibitors of blood coagulation and fibrinolysis

1991 • 173 citations

Vesicular stomatitis virus G proteins with altered glycosylation sites display temperature-sensitive intracellular transport and are subject to aberrant intermolecular disulfide bonding.

1988 • 170 citations

Cell & tissue culture : laboratory procedures

1993 • 162 citations

Lectins and traffic in the secretory pathway

2000 • 145 citations

The Preparation of Subcellular Organelles from Mouse Liver in Self-Generated Gradients of Iodixanol

1994 • 138 citations

Isolation of a cDNA clone for human antithrombin III.

1983 • 134 citations

Accumulation of the insoluble PiZ variant of human alpha 1-antitrypsin within the hepatic endoplasmic reticulum does not elevate the steady-state level of grp78/BiP

1990 • 121 citations

Structural studies on the carbohydrate portion of human antithrombin III.

1980 • 117 citations

Mechanisms and catalysts of disulphide bond formation in proteins

1995 • 105 citations

Intracellular transport of soluble and membrane-bound glycoproteins: folding, assembly and secretion of anchor-free influenza hemagglutinin.

1990 • 97 citations

Glutaminolysis in Animal Cells

1986 • 95 citations

Tunicamycin inhibition of [3H]glucosamine incorporation into yeast glycoproteins: Binding of tunicamycin and interaction with phospholipids

1976 • 93 citations

Effect of cloned gene dosage on cell growth and hepatitis B surface antigen synthesis and secretion in recombinant CHO cells

1992 • 80 citations

Production of Recombinant Proteins in Chinese Hamster Ovary Cells Using A Protein-Free Cell Culture Medium

1995 • 74 citations

Role of protein disulphide-isomerase in the expression of native proteins.

1989 • 66 citations

Expression of human antithrombin III in Saccharomyces cerevisiae and Schizosaccharomyces pombe

1987 • 63 citations

High level synthesis of immunoglobulins in Chinese hamster ovary cells.

1990 • 59 citations

Trans–Activated Expression of Fully Gamma–Carboxylated Recombinant Human Protein C, an Antithrombotic Factor

1987 • 58 citations

Structural studies of the carbohydrate moiety of human antithrombin III

1980 • 55 citations

Characterization of recombinant human antithrombin III synthesized in Chinese hamster ovary cells

1989 • 53 citations

Biochemical determinants of clearance of tissue-type plasminogen activator from the circulation.

1988 • 52 citations

Overexpression of recombinant human antithrombin III in Chinese hamster ovary cells results in malformation and decreased secretion of recombinant protein

1997 • 49 citations

Distribution of protein disulfide isomerase in rat hepatocytes.

1988 • 48 citations

N-glycosylation and the production of recombinant glycoproteins

1989 • 38 citations

Effect of ATP depletion and DTT on the transport of membrane proteins from the endoplasmic reticulum and the intermediate compartment to the Golgi complex.

1995 • 34 citations

Spectrophotometric Determination of Iodixanol in Subcellular Fractions of Mammalian Cells

1997 • 33 citations

Characterization of a bifunctional peptidylglycine α-amidating enzyme expressed in chinese hamster ovary cells

1992 • 29 citations

Quantitative analysis of transcription and translation in gene amplified Chinese hamster ovary cells on the basis of a kinetic model.

1999 • 12 citations

Metabolic rates of vascular endothelial cellsin vitro

1994 • 10 citations