Properties of the Glucocorticoid Modulatory Element Binding Proteins GMEB-1 and -2: Potential New Modifiers of Glucocorticoid Receptor Transactivation and Members of the Family of KDWK Proteins

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

1997 • 1,300 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

Role of CBP/P300 in nuclear receptor signalling

1996 • 935 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

Steroid Hormone Receptors: Interaction with Deoxyribonucleic Acid and Transcription Factors*

1993 • 724 citations

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.

1994 • 649 citations

Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions

1998 • 639 citations

Correlation of Two-Hybrid Affinity Data with In Vitro Measurements

1995 • 536 citations

The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways

1998 • 516 citations

Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex

1998 • 507 citations

Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

1998 • 490 citations

Allosteric effects of DNA on transcriptional regulators

1998 • 488 citations

Nuclear Receptor-Binding Sites of Coactivators Glucocorticoid Receptor Interacting Protein 1 (GRIP1) and Steroid Receptor Coactivator 1 (SRC-1): Multiple Motifs with Different Binding Specificities

1998 • 417 citations

CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.

1996 • 414 citations

Overlapping but Distinct Patterns of Histone Acetylation by the Human Coactivators p300 and PCAF within Nucleosomal Substrates

1999 • 411 citations

Transcription Factor Loading on the MMTV Promoter: A Bimodal Mechanism for Promoter Activation

1992 • 411 citations

Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.

1994 • 354 citations

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

1992 • 341 citations

Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation

1998 • 330 citations

Specific Cytoplasmic Glucocorticoid Hormone Receptors in Hepatoma Tissue Culture Cells

1971 • 328 citations

Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription.

1992 • 308 citations

The acetyltransferase activity of CBP stimulates transcription

1998 • 265 citations

Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors

1993 • 264 citations

The CUG codon is decodedin vivoas serine and not leucine inCandida albicans

1995 • 263 citations

SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers.

1996 • 244 citations

Chromatin Remodeling and the Control of Gene Expression

1997 • 224 citations

Identification of multiple, widely spaced estrogen-responsive regions in the rat progesterone receptor gene.

1994 • 191 citations

Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone-responsive elements.

1993 • 187 citations

Bidirectional transport of glucocorticoid receptors across the nuclear envelope.

1993 • 167 citations

Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase

1998 • 161 citations

A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1

1990 • 154 citations

Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone-regulated chromatin disruption is not sufficient for transcriptional activation

1997 • 149 citations

Structure-activity relationships for glucocorticoids—I: Determination of receptor binding and biological activity

1977 • 147 citations

DEAF-1, a novel protein that binds an essential region in a Deformed response element.

1996 • 138 citations

Protein-protein interactions facilitate DNA binding by the glucocorticoid receptor DNA-binding domain.

1990 • 128 citations

Nucleosome-mediated disruption of transcription factor-chromatin initiation complexes at the mouse mammary tumor virus long terminal repeat in vivo.

1994 • 128 citations

Opposing Effects of Corepressor and Coactivators in Determining the Dose-Response Curve of Agonists, and Residual Agonist Activity of Antagonists, for Glucocorticoid Receptor-Regulated Gene Expression

1999 • 126 citations

Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine

1997 • 121 citations

Mechanistic Principles in NR Box-Dependent Interaction between Nuclear Hormone Receptors and the Coactivator TIF2

1998 • 109 citations

Glucocorticoid-receptor complexes in rat thymus cells. Rapid kinetic behavior and a cyclic model.

1984 • 108 citations

Identification and Characterization of a Leukocyte-specific Component of the Nuclear Body

1996 • 102 citations

Interdomain Signaling in a Two-domain Fragment of the Human Glucocorticoid Receptor

1999 • 102 citations

Refined solution structure of the glucocorticoid receptor DNA-binding domain

1993 • 98 citations

.alpha.-Keto mesylate: a reactive, thiol-specific functional group

1980 • 92 citations

Differential steroid hormone induction of transcription from the mouse mammary tumor virus promoter.

1994 • 87 citations

Induction Properties of a Transiently Transfected Glucocorticoid-responsive Gene Vary with Glucocorticoid Receptor Concentration

1996 • 83 citations

Identification and characterization of estrogen-regulated RNAs in human breast cancer cells.

1988 • 82 citations

Dissociation of Steroid Binding to Receptors and Steroid Induction of Biological Activity in a Glucocorticoid-Responsive Cell

1983 • 79 citations

Coactivator TIF1β Interacts with Transcription Factor C/EBPβ and Glucocorticoid Receptor To Induce α1-Acid Glycoprotein Gene Expression

1998 • 74 citations

Characterization of a Nuclear Deformed Epidermal Autoregulatory Factor-1 (DEAF-1)-Related (NUDR) Transcriptional Regulator Protein

1998 • 73 citations

LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies

1996 • 72 citations

Higher levels of control: modulation of steroid hormone-regulated gene transcription.

1992 • 67 citations

Conditional modulation of glucocorticoid receptor activities by CREB-binding protein (CBP) and p300

1999 • 67 citations

DNA-induced conformational changes are the basis for cooperative dimerization by the DNA binding domain of the retinoid X receptor

1998 • 67 citations

DNA binding analysis of glucocorticoid receptor specificity mutants

1992 • 65 citations

Regulation of Prolactin Production and Cell Growth by Estradiol: Difference in Sensitivity to Estradiol Occurs at Level of Messenger Ribonucleic Acid Accumulation*

1987 • 63 citations

Splice variants of the nuclear dot-associated Sp100 protein contain homologies to HMG-1 and a human nuclear phosphoprotein-box motif

1999 • 61 citations

Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins.

1993 • 52 citations

Developmental regulation of the estrogen receptor and the estrogen responsiveness of five yolk protein genes in the avian liver.

1987 • 49 citations

Determinants of promoter-specific activity by glucocorticoid receptor.

1996 • 48 citations

Modulation of transcription factor activity by a distant steroid modulatory element.

1992 • 47 citations

The Factor Binding to the Glucocorticoid Modulatory Element of the Tyrosine Aminotransferase Gene Is a Novel and Ubiquitous Heteromeric Complex

1995 • 47 citations

Antiglucocorticoid steroids have increased agonist activity in those hepatoma cell lines that are more sensitive to glucocorticoids

1986 • 40 citations

Allosteric Regulation of the Discriminative Responsiveness of Retinoic Acid Receptor to Natural and Synthetic Ligands by Retinoid X Receptor and DNA

1999 • 39 citations

Sequence-selective interactions of transcription factor elements with tandem glucocorticoid-responsive elements at physiological steroid concentrations.

1993 • 37 citations

Cloning and Characterization of a Novel Binding Factor (GMEB-2) of the Glucocorticoid Modulatory Element

1998 • 35 citations

Higher levels of control: modulation of steroid hormone-regulated gene transcription

1992 • 34 citations

Two New Members of the Emerging KDWK Family of Combinatorial Transcription Modulators Bind as a Heterodimer to Flexibly Spaced PuCGPy Half-Sites

1999 • 33 citations

Modulation of glucocorticoid induction of tyrosine aminotransferase gene expression by variations in cell density.

1992 • 30 citations

Modulation of transcription factor activity by a distant steroid modulatory element

1992 • 27 citations

Effects of oestrogen and the antioestrogens, tamoxifen and LY117018, on four oestrogen-regulated RNAs in the EFM-19 breast cancer cell line

1989 • 27 citations

Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein

1999 • 27 citations

Ability of the glucocorticoid modulatory element to modify glucocorticoid receptor transactivation indicates parallel pathways for the expression of glucocorticoid modulatory element and glucocorticoid response element activities

2000 • 26 citations

Repression of the alpha-fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and antihormones.

1990 • 26 citations

Modulation of glucocorticoid induction of stably transfected tyrosine aminotransferase gene constructs involves elements up-stream of the glucocorticoid-responsive element.

1992 • 24 citations

Unlinked Regulation of the Sensitivity of Primary Glucocorticoid-Inducible Responses in Mouse Mammary Tumor Virus Infected Fu5-5 Rat Hepatoma Cells

1988 • 23 citations

Differential modulation of gene induction by glucocorticoids and antiglucocorticoids in rat hepatoma tissue culture cells.

1989 • 21 citations

A negative tyrosine aminotransferase gene element that blocks glucocorticoid modulatory element-regulated modulation of glucocorticoid-induced gene expression.

1996 • 21 citations

Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins

2000 • 21 citations

Modulation of TAT gene induction by glucocorticoids involves a neutralizing sequence

1998 • 15 citations