Induction Properties of a Transiently Transfected Glucocorticoid-responsive Gene Vary with Glucocorticoid Receptor Concentration

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.

1993 • 749 citations

Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA

1986 • 722 citations

Negative effect of the transcriptional activator GAL4

1988 • 672 citations

The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.

1995 • 627 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Dopaminergic and Ligand-Independent Activation of Steroid Hormone Receptors

1991 • 577 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I.

1993 • 442 citations

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

1995 • 431 citations

Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor

1994 • 402 citations

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

1992 • 354 citations

Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element.

1993 • 322 citations

The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific

1989 • 299 citations

Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements

1989 • 270 citations

Glucocorticoid Receptor Mutants That Define a Small Region Sufficient for Enhancer Activation

1987 • 260 citations

Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors.

1990 • 257 citations

The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.

1993 • 208 citations

Structural Determinants of a Glucocorticoid Receptor Recognition Element

1990 • 201 citations

Dexamethasone 21-mesylate: an affinity label of glucocorticoid receptors from rat hepatoma tissue culture cells.

1981 • 190 citations

Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP

1993 • 181 citations

Domains of the Glucocorticoid Receptor Involved in Specific and Nonspecific Deoxyribonucleic Acid Binding, Hormone Activation, and Transcriptional Enhancement

1987 • 174 citations

LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones.

1995 • 161 citations

The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional acitivity

1994 • 153 citations

Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms.

1990 • 146 citations

Identification of cysteine 656 as the amino acid of hepatoma tissue culture cell glucocorticoid receptors that is covalently labeled by dexamethasone 21-mesylate.

1987 • 125 citations

Latent agonist activity of the steroid antagonist, RU486, is unmasked in cells treated with activators of protein kinase A.

1993 • 109 citations

Enhancement of human estrogen receptor activity by SPT6: a potential coactivator.

1995 • 99 citations

Refined solution structure of the glucocorticoid receptor DNA-binding domain

1993 • 98 citations

Identification of a negative regulatory function for steroid receptors.

1992 • 98 citations

Obligatory separation of hormone binding and biological response curves in systems dependent upon secondary mediators of hormone action.

1981 • 96 citations

The role of activators in assembly of RNA polymerase II transcription complexes

1994 • 86 citations

A new version of the two-hybrid assay for detection of protein-protein interactions

1995 • 80 citations

Efficient Binding of Glucocorticoid Receptor to Its Responsive Element Requires a Dimer and DNA Flanking Sequences

1990 • 79 citations

Differential effect of forms A and B of human progesterone receptor on estradiol-dependent transcription.

1994 • 77 citations

Detection and modulation in vivo of helix-loop-helix protein-protein interactions.

1993 • 73 citations

Higher levels of control: modulation of steroid hormone-regulated gene transcription.

1992 • 67 citations

DNA binding analysis of glucocorticoid receptor specificity mutants

1992 • 65 citations

Direct interaction of the tau 1 transactivation domain of the human glucocorticoid receptor with the basal transcriptional machinery.

1993 • 63 citations

A conserved carboxy-terminal subdomain is important for ligand interpretation and transactivation by nuclear receptors.

1994 • 58 citations

DNA binding specificity of mutant glucocorticoid receptor DNA-binding domains.

1991 • 54 citations

Function/Activity of Specific Amino Acids in Glucocorticoid Receptors

1994 • 51 citations

Modulation of transcription factor activity by a distant steroid modulatory element.

1992 • 47 citations

Newly expressed progesterone receptor cannot activate stable, replicated mouse mammary tumor virus templates but acquires transactivation potential upon continuous expression.

1993 • 42 citations

Sequence-selective interactions of transcription factor elements with tandem glucocorticoid-responsive elements at physiological steroid concentrations.

1993 • 37 citations

Differential regulation of human progesterone receptor A and B form-mediated trans-activation by phosphorylation.

1993 • 34 citations

Modular Structure of Glucocorticoid Receptor Domains Is Not Equivalent to Functional Independence

1996 • 34 citations

Modulation of glucocorticoid induction of tyrosine aminotransferase gene expression by variations in cell density.

1992 • 30 citations

Modulation of glucocorticoid induction of stably transfected tyrosine aminotransferase gene constructs involves elements up-stream of the glucocorticoid-responsive element.

1992 • 24 citations

Glucocorticoid-specific gene activation by the intact human glucocorticoid receptor expressed in yeast. Glucocorticoid specificity depends on low level receptor expression.

1992 • 24 citations

Reconstitution of ligand-mediated glucocorticoid receptor activity by trans-acting functional domains.

1993 • 23 citations

Overexpression of the glucocorticoid receptor represses transcription from hormone responsive and non-responsive promoters

1992 • 23 citations

Molecular identification of steroid analogs with dissociated antiprogestin activities

1995 • 21 citations

Description and analysis of differential sensitivity to glucocorticoids in Fao cells

1988 • 9 citations