Phenotypic variability in human embryonic holoprosencephaly in the Kyoto Collection

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Embryonic Development and Induction

1939 • 1,175 citations

Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

1996 • 1,140 citations

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

2000 • 704 citations

THE FACE PREDICTS THE BRAIN: DIAGNOSTIC SIGNIFICANCE OF MEDIAN FACIAL ANOMALIES FOR HOLOPROSENCEPHALY (ARHINENCEPHALY)

1964 • 661 citations

Handbook of clinical neurology

1993 • 593 citations

Embryonic Development and Induction

1938 • 459 citations

Hedgehog–GLI signaling and the growth of the brain

2002 • 360 citations

The Mutational Spectrum of the Sonic Hedgehog Gene in Holoprosencephaly: SHH Mutations Cause a Significant Proportion of Autosomal Dominant Holoprosencephaly

1999 • 353 citations

The role of Sonic hedgehog in normal and abnormal craniofacial morphogenesis

1999 • 338 citations

Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features

2003 • 336 citations

Holoprosencephaly in human embryos: Epidemiologic studies of 150 cases

1977 • 320 citations

Developmental Stages in Human Embryos: Including a Revision of Streeter's Horizons and a Survey of the Carnegie Collection

1987 • 315 citations

Multiple Hits during Early Embryonic Development: Digenic Diseases and Holoprosencephaly

2002 • 307 citations

Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning

1999 • 292 citations

Congenital Malformations. Notes and Comments

1972 • 291 citations

Hedgehog signaling is required for pituitary gland development

2001 • 290 citations

A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate

1997 • 270 citations

Perspectives on holoprosencephaly: Part I. Epidemiology, genetics, and syndromology

1989 • 260 citations

CONGENITAL MALFORMATIONS

1973 • 260 citations

Alobar Holoprosencephaly (Arhinencephaly) with Median Cleft Lip and Palate: Clinical, Electroencephalographic and Nosologic Considerations (Part 1 of 2)

1963 • 251 citations

Normal and abnormal development of human embryos: First report of the analysis of 1,213 intact embryos

1968 • 243 citations

Perspectives on holoprosencephaly: Part III. Spectra, distinctions, continuities, and discontinuities

1989 • 222 citations

Teratogenesis of holoprosencephaly

2002 • 195 citations

Early steps in pituitary organogenesis

1999 • 153 citations

Perspectives on holoprosencephaly: Part II. Central nervous system, craniofacial anatomy, syndrome commentary, diagnostic approach, and experimental studies.

1992 • 138 citations

The Problem of Cyclopia. Part I

1936 • 129 citations

Optic cup morphogenesis requires pre-lens ectoderm but not lens differentiation

2003 • 112 citations

Holoprosencephaly and agenesis of the corpus callosum: Frequency of Associated Malformations

1981 • 108 citations

Development and Intrauterine Fate of Normal and Abnormal Human Conceptuses

1991 • 97 citations

The development and morphogenesis of the human pituitary gland

1988 • 96 citations

Review Article: Holoprosencephaly and Related Midline Cerebral Anomalies: A Review

1986 • 91 citations

Experimental studies on the eye of the frog embryo

1905 • 89 citations

Prenatal versus Postnatal Malformations Based on the Japanese Experience on Induced Abortions in the Human Being

2015 • 88 citations

The interplay of genetic and environmental factors in craniofacial morphogenesis: holoprosencephaly and the role of cholesterol

2003 • 77 citations

Interpretation of some median anomalies as illustrated by cyclopia and symmelia

1989 • 72 citations

Mediobasal prosencephalic defects, including holoprosencephaly and cyclopia, in relation to the development of the human forebrain

1989 • 70 citations

The Early Development of Morphology and Patterns of the Face in the Human Embryo

1985 • 67 citations

Experimental studies on the development of the eye. III. The effect of the substrate (‘Unterlagerung’) on the heterotopic development of median and lateral strips of the anterior end of the neural plate of amblystoma

1930 • 64 citations

Experiments on the origin and differentiation of the optic vesicle in amphibia

1907 • 62 citations

The experimental production of cyclopia in the fish embryo (Fundulus heteroclitus)

1909 • 57 citations

Normal development of early human embryos: Observation of 90 specimens at Carnegie stages 7 to 13

1974 • 57 citations

Experimental studies on the development of the eye. II. The eye‐forming potencies of the median portions of the urodelan neural plate (Triton teniatus and Amblystoma punctatum)

1929 • 53 citations

The Problem of Cyclopia. Part II

1936 • 53 citations

Human fetal pituitary gland in holoprosencephaly and anencephaly.

1995 • 51 citations

Experimental studies on the development of the eye. I. The effect of the removal of median and lateral areas of the anterior end of the urodelan neural plate on the development of the eyes (Triton teniatus and Amblystoma punctatum)

1929 • 48 citations

ARHINENCEPHALY

1987 • 46 citations

Synophthalmia and cyclopia: A histopathologic, radiographic, and organogenetic analysis

1977 • 45 citations

An anatomic comparison of cebocephaly and ethmocephaly

1990 • 29 citations

Experimental production of perfect cyclopia in the chick by means of LiCl, with a survey of the literature on cyclopia produced experimentally by various means

1963 • 22 citations

Teratothanasia: prenatal loss of abnormal conceptuses and the prevalence of various malformations during human gestation.

1993 • 21 citations

Experimental production of perfect cyclopia by removal of the telencephalon and reversal of bilateralization in somite‐stage chicks

1964 • 18 citations

Absence of the optic nerve in cyclopia

1945 • 17 citations

The Question of Cyclopia, One-Eyed Monsters

1908 • 16 citations

Computerized three-dimensional reconstruction of the brain of normal and holoprosencephalic human embryos.

1993 • 7 citations