Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis
Data up to Jan 2025
Total Citations Per Year
Abstract
References (174)
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 • 10,051 citations
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
1984 • 5,166 citations
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
1992 • 5,156 citations
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
1987 • 4,544 citations
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 • 4,449 citations
Inflammation and Alzheimer's disease
2000 • 4,315 citations
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
2003 • 3,943 citations
β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE
1999 • 3,692 citations
Hearing loss and cognitive decline in older adults.
2013 • 2,798 citations
Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
2000 • 2,700 citations
Neurodegenerative Tauopathies
2001 • 2,276 citations
Diabetes mellitus and the risk of dementia
1999 • 2,031 citations
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
1996 • 1,955 citations
Oxidative Damage Is the Earliest Event in Alzheimer Disease
2001 • 1,833 citations
Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective
2005 • 1,772 citations
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 • 1,592 citations
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
1991 • 1,590 citations
APP Processing and Synaptic Function
2003 • 1,575 citations
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
1999 • 1,483 citations
Mitochondrial Abnormalities in Alzheimer's Disease
2001 • 1,319 citations
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
2003 • 1,289 citations
Mechanisms of Memory
1986 • 1,252 citations
Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
1997 • 1,241 citations
Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies
2002 • 1,166 citations
Midlife cardiovascular risk factors and risk of dementia in late life
2005 • 1,154 citations
Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes
2002 • 1,055 citations
S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
2009 • 1,016 citations
Tau pathology in Alzheimer disease and other tauopathies
2004 • 967 citations
Increased Risk of Type 2 Diabetes in Alzheimer Disease
2004 • 872 citations
Opposing Activities Protect Against Age-Onset Proteotoxicity
2006 • 844 citations
APP processing in Alzheimer's disease
2011 • 815 citations
Regulation of protein kinase cascades by protein phosphatase 2A
1999 • 798 citations
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
2003 • 744 citations
Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease
1998 • 728 citations
Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
2008 • 713 citations
Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
2005 • 703 citations
Functionally significant insulin-like growth factor I receptor mutations in centenarians
2008 • 680 citations
A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway
1997 • 678 citations
Hyperinsulinemia and risk of Alzheimer disease
2004 • 666 citations
A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation
1998 • 653 citations
Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers
2009 • 617 citations
Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
2004 • 609 citations
Role for neuronal insulin resistance in neurodegenerative diseases
2004 • 601 citations
Identification of insulin in rat brain.
1978 • 599 citations
Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease
2002 • 559 citations
Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation
1997 • 543 citations
Recruitment of functional GABAA receptors to postsynaptic domains by insulin
1997 • 531 citations
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane‐bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
2008 • 519 citations
Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons
1997 • 517 citations
Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI
2003 • 496 citations
Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis
2005 • 496 citations
Insulin receptors and insulin action in the brain: review and clinical implications
2000 • 478 citations
Differential expression of insulin-like growth factor genes in rat central nervous system.
1988 • 477 citations
The source of cerebral insulin
2004 • 473 citations
Laying it on thick
1999 • 471 citations
Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation
2003 • 468 citations
Insulin Resistance and Alzheimers Disease Pathogenesis: Potential Mechanisms and Implications for Treatment
2007 • 466 citations
Receptor-Mediated Transport of Insulin Across Endothelial Cells
1985 • 462 citations
Serum insulin-like growth factor I regulates brain amyloid-β levels
2002 • 440 citations
Involvement of Microglial Receptor for Advanced Glycation Endproducts (RAGE) in Alzheimer's Disease: Identification of a Cellular Activation Mechanism
2001 • 412 citations
Clearance of Alzheimer's Aβ Peptide
2004 • 411 citations
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
2007 • 408 citations
Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.
1993 • 401 citations
Direct demonstration that receptor crosslinking or aggregation is important in insulin action
1978 • 388 citations
Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects
1991 • 386 citations
Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
2003 • 386 citations
The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer’s Disease
2002 • 371 citations
Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice
2003 • 367 citations
The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice
2007 • 361 citations
Interleukin-1, neuroinflammation, and Alzheimer's disease
2001 • 353 citations
Fundamental neuroscience
1997 • 335 citations
Insulin gene expression and insulin synthesis in mammalian neuronal cells.
1994 • 327 citations
Signaling by insulin-like growth factor 1 in brain
2004 • 322 citations
Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease
2007 • 321 citations
Protein Kinase C-dependent α-Secretase Competes with β-Secretase for Cleavage of Amyloid-β Precursor Protein in the Trans-Golgi Network
2000 • 320 citations
Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: Relevance to Alzheimer's disease
2006 • 319 citations
Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose
1999 • 315 citations
Insulin and the Blood-Brain Barrier
2003 • 314 citations
Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease
2005 • 312 citations
Transport of Insulin Across the Blood-Brain Barrier: Saturability at Euglycemic Doses of Insulin
1997 • 312 citations
Insulin-Degrading Enzyme as a Downstream Target of Insulin Receptor Signaling Cascade: Implications for Alzheimer's Disease Intervention
2004 • 312 citations
Insulin promotes rapid delivery of N -methyl- <scp>d</scp> - aspartate receptors to the cell surface by exocytosis
2001 • 300 citations
Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeability
1985 • 297 citations
Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD
2004 • 293 citations
The Role of Insulin in Human Brain Glucose Metabolism
2002 • 284 citations
The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease
2004 • 258 citations
Ceramide Stabilizes β-Site Amyloid Precursor Protein-cleaving Enzyme 1 and Promotes Amyloid β-Peptide Biogenesis
2003 • 258 citations
Insulin dose–response effects on memory and plasma amyloid precursor protein in Alzheimer’s disease: interactions with apolipoprotein E genotype
2003 • 253 citations
Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases.
1999 • 237 citations
Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease.
2002 • 233 citations
Insulin Transiently Increases Tau Phosphorylation
1999 • 233 citations
Insulin Dysfunction InducesIn VivoTau Hyperphosphorylation through Distinct Mechanisms
2007 • 227 citations
β-Amyloid1–42Induces Neuronal Death through the p75 Neurotrophin Receptor
2008 • 218 citations
Regional Concentrations of Insulin in the Rat Brain*
1983 • 216 citations
Differential effects of oligomeric and fibrillar amyloid-β1–42 on astrocyte-mediated inflammation
2005 • 215 citations
Hyperinsulinemia Provokes Synchronous Increases in Central Inflammation and β-Amyloid in Normal Adults
2005 • 213 citations
Insulin and insulin-like growth factor receptors in the nervous system
1989 • 207 citations
Hydrogen peroxide‐mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca2+ and PI3‐kinase
2001 • 206 citations
Noradrenergic Depletion Potentiates β-Amyloid-Induced Cortical Inflammation: Implications for Alzheimer's Disease
2002 • 206 citations
Circulating Levels of Soluble Receptor for Advanced Glycation End Products in Alzheimer Disease and Vascular Dementia
2005 • 206 citations
Insulin Effects on Glucose Metabolism, Memory, and Plasma Amyloid Precursor Protein in Alzheimer's Disease Differ According to Apolipoprotein‐E Genotype
2000 • 188 citations
A biochemical and functional characterization of diet‐induced brain insulin resistance
2005 • 188 citations
Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update
2000 • 177 citations
Increased TNF-α-Induced Apoptosis in Lymphocytes from Aged Humans: Changes in TNF-α Receptor Expression and Activation of Caspases
1999 • 174 citations
Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer’s disease
2002 • 171 citations
Insulin-sensitive GLUT4 glucose transporters are colocalized with GLUT3-expressing cells and demonstrate a chemically distinct neuron-specific localization in rat brain
1999 • 171 citations
Akt activity in Alzheimer’s disease and other neurodegenerative disorders
2004 • 166 citations
Alzheimer's disease: treatments in discovery and development
2002 • 164 citations
Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice
2004 • 163 citations
IGF-1 Modulates N and L Calcium Channels in a PI 3-Kinase-Dependent Manner
1997 • 163 citations
The Role of Insulin, Insulin Growth Factor, and Insulin‐Degrading Enzyme in Brain Aging and Alzheimer′s Disease
2005 • 162 citations
NEURONAL DEGENERATION IN LOCUS CERULEUS AND CORTICAL CORRELATES OF ALZHEIMER DISEASE
1987 • 160 citations
Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology
2008 • 152 citations
Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential
2000 • 152 citations
Insulin Metabolism in Alzheimer’s Disease Differs According to Apolipoprotein E Genotype and Gender
1999 • 151 citations
Insulin stimulates interleukin-6 and tumor necrosis factor-α gene expression in human subcutaneous adipose tissue
2004 • 147 citations
Genetically obese zucker rats have abnormally low brain insulin content
1985 • 140 citations
Memory improvement by glucose, fructose, and two glucose analogs: A possible effect on peripheral glucose transport
1987 • 140 citations
Peripheral Hyperinsulinemia Promotes Tau Phosphorylation In Vivo
2005 • 139 citations
The Role of IGF-1 Receptor and Insulin Receptor Signaling for the Pathogenesis of Alzheimers Disease: From Model Organisms to Human Disease
2009 • 138 citations
Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: New cues into the human disease?
2005 • 129 citations
Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology
2008 • 128 citations
The Induction of the TNF Death Domain Signaling Pathway in Alzheimer's Disease Brain
2003 • 128 citations
Role of Insulin-Like Growth Factor Iin Maintaining Normal Glucose Homeostasis
2004 • 124 citations
Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus
1993 • 123 citations
Molecular mechanisms of insulin receptor substrate protein‐mediated modulation of insulin signalling
2003 • 123 citations
An aging pathway controls the TrkA to p75NTR receptor switch and amyloid β-peptide generation
2006 • 123 citations
Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization
1989 • 122 citations
Cerebrospinal Fluid Aβ42, Tau, and F2-Isoprostane Concentrations in Patients With Alzheimer Disease, Other Dementias, and in Age-Matched Controls
2001 • 120 citations
Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons
2000 • 119 citations
Insulin-like growth factor I (IGF-I) and cognitive decline in older persons
2003 • 118 citations
Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: Potential strategies for neuroprotection1
2003 • 116 citations
Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans
2002 • 116 citations
RAGE regulates BACE1 and Aβ generationviaNFAT1 activation in Alzheimer's disease animal model
2009 • 114 citations
Localization and regulation of GLUTx1 glucose transporter in the hippocampus of streptozotocin diabetic rats
2001 • 111 citations
Insulin stimulates receptor-mediated uptake of apoE-enriched lipoproteins and activated alpha 2-macroglobulin in adipocytes.
1993 • 106 citations
Effects of insulinic therapy on cognitive impairment in patients with Alzheimer disease and Diabetes Mellitus type-2
2009 • 104 citations
Clearance of Alzheimer's Aβ PeptideThe Many Roads to Perdition
2004 • 96 citations
Diabetes, Alzheimer's disease and apolipoprotein genotype
2003 • 94 citations
Tau Is Hyperphosphorylated in the Insulin-Like Growth Factor-I Null Brain
2005 • 93 citations
Processing of Insulin by Bovine Endothelial Cells in Culture: Internalization Without Degradation
1984 • 90 citations
The role of the metabolic lesion in Alzheimer's disease
2002 • 89 citations
Endothelium, inflammation, and diabetes
2002 • 86 citations
IGF-1-induced Processing of the Amyloid Precursor Protein Family Is Mediated by Different Signaling Pathways
2007 • 78 citations
Aging of the brain, neurotrophin signaling, and Alzheimer's disease: Is IGF1-R the common culprit?
2007 • 77 citations
Splice variants of the receptor for advanced glycosylation end products (RAGE) in human brain
2004 • 77 citations
Learning and Memory
2014 • 73 citations
Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation
2011 • 73 citations
Brain Glucose Metabolism Is Controlled by Amplification and Desensitization of the Neuronal Insulin Receptora
1996 • 71 citations
Genetics of interleukin 6: implications for Alzheimer's disease
2001 • 70 citations
Soluble Tumor Necrosis Factor-α Receptors in Young Obese Subjects With Normal and Impaired Glucose Tolerance
2003 • 68 citations
Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice
2006 • 65 citations
Variations in plasma soluble tumour necrosis factor receptors after diet‐induced weight loss in obesity
2000 • 62 citations
Glutamate Acting on N-Methyl-d-aspartate Receptors Attenuates Insulin-like Growth Factor-1 Receptor Tyrosine Phosphorylation and Its Survival Signaling Properties in Rat Hippocampal Neurons
2008 • 57 citations
Apolipoprotein E mRNA in the brains of patients with Alzheimer's disease
1995 • 56 citations
Oxidative damage in Alzheimer’s disease
2015 • 56 citations
Receptor for advanced glycation end products: its role in Alzheimer’s disease and other neurological diseases
2009 • 49 citations
Immunohistochemical and in situ hybridization study of an insulin-like substance in fetal neuron cell cultures
1994 • 47 citations
Insulin, Prostaglandins, and the Pathogenesis of Hypertension
1991 • 46 citations
Insulin-like Growth Factor-1 (IGF-1)-induced Processing of Amyloid-β Precursor Protein (APP) and APP-like Protein 2 Is Mediated by Different Metalloproteinases
2010 • 43 citations
Effect of Combinations of Insulin, Glucose and Scopolamine on Radial Arm Maze Performance
1997 • 42 citations
Region-specific alterations in insulin-like growth factor receptor type I in the cerebral cortex and hippocampus of aged rats
2002 • 41 citations
Targeting insulin-like growth factor-1 to treat Alzheimer's disease
2007 • 40 citations
Constitutive overactivation of protein kinase C in guinea pig brain increases α‐secretory APP processing without decreasing β‐amyloid generation
2000 • 40 citations
The effect of insulin on norepinephrine uptake by PC12 cells
1993 • 39 citations
Peripheral elevation of IGF-1 fails to alter Aβ clearance in multiple in vivo models
2007 • 35 citations
GRK5 Deficiency Accelerates β-Amyloid Accumulation in Tg2576 Mice via Impaired Cholinergic Activity
2010 • 34 citations
Insulin attenuates scopolamine-induced memory deficits
1994 • 31 citations
Metabolic Changes in Alzheimer's Disease
1988 • 25 citations
Processing of insulin by bovine endothelial cells in culture. Internalization without degradation
1984 • 24 citations
125I-insulin binding is decreased in olfactory bulbs of aged rats
1990 • 20 citations
The spin trapping agent PBN stimulates H2O2-induced Erk and Src kinase activity in human neuroblastoma cells
2002 • 20 citations
Insulin, prostaglandins, and the pathogenesis of hypertension
1991 • 14 citations
Well does He?
1989 • 1 citations