Tau Is Hyperphosphorylated in the Insulin-Like Growth Factor-I Null Brain

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES

1995 • 3,305 citations

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

Neurodegenerative Tauopathies

2001 • 2,276 citations

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 • 2,057 citations

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

2001 • 1,583 citations

The distribution of tau in the mammalian central nervous system.

1985 • 1,518 citations

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

2001 • 1,398 citations

Positron Emission Tomography in Evaluation of Dementia

2001 • 882 citations

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

2001 • 865 citations

Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model

2003 • 863 citations

IGF-I is required for normal embryonic growth in mice.

1993 • 810 citations

Tau protein pathology in neurodegenerative diseases

1998 • 674 citations

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

2000 • 661 citations

Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons

1997 • 517 citations

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

1992 • 468 citations

Distribution of Active Glycogen Synthase Kinase 3β (GSK-3β) in Brains Staged for Alzheimer Disease Neurofibrillary Changes

1999 • 448 citations

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

1997 • 438 citations

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

1992 • 415 citations

Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

2004 • 412 citations

Neurons Undergo Apoptosis in Animal and Cell Culture Models of Diabetes

1999 • 410 citations

Lipofuscin: Mechanisms of formation and increase with age

1998 • 364 citations

Spatial learning deficit in transgenic mice that conditionally over‐express GSK‐3β in the brain but do not form tau filaments

2002 • 360 citations

PAR-1 Kinase Plays an Initiator Role in a Temporally Ordered Phosphorylation Process that Confers Tau Toxicity in Drosophila

2004 • 319 citations

Glycogen Synthase Kinase-3β Phosphorylates Protein Tau and Rescues the Axonopathy in the Central Nervous System of Human Four-repeat Tau Transgenic Mice

2000 • 313 citations

Activation of tau protein kinase I/glycogen synthase kinase-3β by amyloid β peptide (25–35) enhances phosphorylation of tau in hippocampal neurons

1998 • 281 citations

Potential roles of insulin and IGF-1 in Alzheimer's disease

2003 • 272 citations

Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy

2004 • 264 citations

The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease

2004 • 258 citations

Influence of Age and Long-term Dietary Restriction on Plasma Insulin-like Growth Factor-1 (IGF-1), IGF-1 Gene Expression, and IGF-1 Binding Proteins

1991 • 237 citations

Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.

1997 • 232 citations

Hyperphosphorylation of Tau in PHF

1995 • 220 citations

Insulin-like Growth Factor-1-mediated Neuroprotection against Oxidative Stress Is Associated with Activation of Nuclear Factor κB

1999 • 205 citations

Insulin-like growth factor 1 regulates developing brain glucose metabolism

2000 • 199 citations

Cellular Pattern of Insulin-Like Growth Factor-I (IGF-I) and IGF-I Receptor Gene Expression in the Developing and Mature Ovarian Follicle

1991 • 164 citations

Insulin‐like growth factor 1 is essential for normal dendritic growth

2003 • 156 citations

Unique Alzheimer's Disease Paired Helical Filament Specific Epitopes Involve Double Phosphorylation at Specific Sites

1997 • 151 citations

Insulin-like growth factor-I, cognition and brain aging

2004 • 136 citations

Tau Phosphorylation, Tangles, and Neurodegeneration

2003 • 126 citations

Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats

1999 • 124 citations

Role of insulin-like growth factor I signaling in neurodegenerative diseases

2004 • 107 citations

Biochemical and Morphometric Analyses Show that Myelination in the Insulin-like Growth Factor 1 Null Brain Is Proportionate to Its Neuronal Composition

1998 • 106 citations

Effects ofIgf1Gene Deletion on Postnatal Growth Patterns

1999 • 86 citations

Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells

1998 • 85 citations

A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake

1997 • 67 citations

Insulin‐like growth factor type 1 prevents hyperglycemia‐induced uncoupling protein 3 down‐regulation and oxidative stress

2004 • 55 citations

Reduced expression of insulin-like growth factor 1 messenger RNA in the hippocampus of aged rats

2000 • 50 citations

Overexpression of GSK3 ^S9AResulted in Tau Hyperphosphorylation and Morphology Reminiscent of Pretangle-Like Neurons in the Brain of PDGSK3 Transgenic Mice

2004 • 26 citations