Numb Antagonizes Notch Signaling to Specify Sibling Neuron Cell Fates

Notch Signaling

1995 • 1,282 citations

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1995 • 1,099 citations

Cleavage orientation and the asymmetric inheritance of notchl immunoreactivity in mammalian neurogenesis

1995 • 764 citations

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

1994 • 749 citations

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

1990 • 675 citations

Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch

1996 • 656 citations

The suppressor of hairless protein participates in notch receptor signaling

1994 • 547 citations

numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos

1989 • 493 citations

Asymmetric segregation of Numb and Prospero during cell division

1995 • 489 citations

Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)

1995 • 476 citations

Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos

1995 • 407 citations

Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system

1992 • 397 citations

The PROSPERO transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila

1996 • 333 citations

A dual function of the Notch gene in Drosophila sensillum development

1990 • 333 citations

Asymmetric segregation of the homeodomain protein Prospero duringDrosophila development

1995 • 330 citations

Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats

1995 • 324 citations

Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates

1992 • 264 citations

Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS

1995 • 249 citations

Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development

1993 • 222 citations

Regulation of proneural gene expression and cell fate during neuroblast segregation in the Drosophila embryo

1992 • 211 citations

The genetic basis of patterned baldness in Drosophila

1994 • 182 citations

Maggot's hair and bug's eye: Role of cell interactions and intrinsic factors in cell fate specification

1995 • 180 citations

Embryogenesis of an insect nervous system II: A second class of neuron precursor cells and the origin of the intersegmental connectives

1981 • 170 citations

Neuronal determination during embryonic development of the grasshopper nervous system

1985 • 113 citations

Differentiation of neurons and myocytes in cell cultures made from Drosophila gastrulae

1971 • 113 citations

tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the drosophila PNS

1995 • 110 citations

Delta Function Is Required for Bristle Organ Determination and Morphogenesis in Drosophila

1993 • 106 citations

The achaete‐scute complex: generation of cellular pattern and fate within the Drosophila nervous system

1994 • 95 citations

The formation of commissures in the Drosophila CNS depends on the midline cells and on the Notch gene

1994 • 71 citations

The molecular genetics of the Notch locus in Drosophila melanogaster

1985 • 56 citations

Cell-cell interactions that specify certain cell fates in C. elegans development

1989 • 39 citations

Deleted Work

1955 • 0 citations