Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

1991 • 997 citations

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

1989 • 643 citations

Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

1988 • 465 citations

The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects

1989 • 458 citations

Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process

1985 • 373 citations

Expression of Modified Human Cytochrome P450 3A4 in Escherichia coli and Purification and Reconstitution of the Enzyme

1993 • 341 citations

Carcinogenicities of heterocyclic amines in cooked food

1991 • 318 citations

Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene

1990 • 281 citations

Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

1990 • 280 citations

Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.

1986 • 258 citations

Occurrence, identification, and bacterial mutagenicity of heterocyclic amines in cooked food

1991 • 258 citations

Oxidation of Aflatoxin B1 by Bacterial Recombinant Human Cytochrome P450 Enzymes

1995 • 208 citations

Detection of a carcinogen, 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP), in cigarette smoke condensate

1991 • 171 citations

Expression of Modified Human Cytochrome P450 1A1 in Escherichia coli: Effects of 5′ Substitution, Stabilization, Purification, Spectral Characterization, and Catalytic Properties

1994 • 108 citations

Biochemical Individuality and Its Implications for Drug and Carcinogen Metabolism: Recent Insights from Acetyltransferase and Cytochrome P4501a2 Phenotyping and Genotyping in Humans

1994 • 81 citations

Characterization of the inhibition of P4501A2 by furafylline

1994 • 73 citations

Human cDNA‐Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate Specificity

1989 • 72 citations

Species differences in the biotransformation of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by hepatic microsomes and cytosols from humans, rats, and mice.

1995 • 67 citations

Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids.

1992 • 26 citations

Carcinogenic aromatic amine metabolism and DNA adduct detection in humans.

1990 • 22 citations