Expression of arylamine N-acetyltransferase in human intestine

N-acetylation pharmacogenetics.

1985 • 637 citations

ROLE OF N-ACETYLTRANSFERASE PHENOTYPES IN BLADDER CARCINOGENESIS: A PHARMACOGENETIC EPIDEMIOLOGICAL APPROACH TO BLADDER CANCER

1982 • 501 citations

Nomenclature for N-acetyltransferases

1995 • 378 citations

Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process

1985 • 373 citations

Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases

1993 • 356 citations

Cigarette Smoking, N-Acetyltransferase 2 Genetic Polymorphisms, and Breast Cancer Risk

1996 • 334 citations

Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens

1994 • 276 citations

Human acetyltransferase polymorphisms

1997 • 267 citations

Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue.

1995 • 233 citations

Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer

1995 • 230 citations

Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer.

1995 • 222 citations

Correlation between acetylator phenotypes and genotypes of polymorphic arylamine N-acetyltransferase in human liver.

1990 • 182 citations

Partial purification and properties of the isoniazid transacetylase in human liver. Its relationship to the acetylation of p-aminosalicylic acid.

1965 • 132 citations

Renal tubular dysfunction in patients with inflammatory bowel disease treated with aminosalicylate.

1997 • 102 citations

INTRAORAL AND PULMONARY TUBERCULOSIS FOLLOWING DENTAL TREATMENT

1982 • 95 citations

Aromatic amine acetyltransferase as a marker for colorectal cancer: Environmental and demographic associations

1990 • 92 citations

Mapping AAC1, AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours

1997 • 85 citations

Immunochemical detection of arylamine N-acetyltransferase in normal and neoplastic bladder.

1996 • 80 citations

Genotyping Human Arylamine N-Acetyltransferase Type 1 (NAT1)

1998 • 78 citations

Acetylation polymorphism and prevalence of colorectal adenomas.

1995 • 77 citations

Distribution of 2-aminofluorene and p-aminobenzoic acid N-acetyltransferase activity in tissues of C57BL/6J rapid and B6.A-NatS slow acetylator congenic mice.

1993 • 74 citations

Role of acetylation in colorectal cancer

1993 • 72 citations

ACCELERATED PAPER: Lack of association between the polyadenylation polymorphism in the NATl (acetyltransferase 1) gene and colorectal adenomas

1996 • 71 citations

Allyl isothiocyanate is mutagenic in Salmonella typhimurium

1985 • 69 citations

N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions

1997 • 65 citations

Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk

1996 • 64 citations

Expression of monomorphic and polymorphic N-acetyltransferases in human colon

1994 • 57 citations

Enzyme kinetic properties of human recombinant arylamine n-acetyltransferase 2 allotypic variants expressed in Escherichia coli

1995 • 56 citations

DNA adducts formed from the probable proximate carcinogen, N-hydroxy-3,2′ -dimethyl-4-aminobiphenyl, by acid catalysis or S-acetyl coenzyme A-dependent enzymatic esterification

1985 • 48 citations

Heterocyclic amines: evaluation of their role in diet associated human cancer

1996 • 46 citations

Localization of polymorphic N-acetyltransferase (NAT2) in tissues of inbred mice

1997 • 43 citations

Detailed physical and deletion mapping of 8p with isolation of YAC clones from tumour suppressor loci involved in colorectal cancer.

1996 • 43 citations

Kinetics of arylamine N-acetyltransferase in tissues from rapid and slow acetylator mice

1987 • 39 citations

Animal models of inflammatory bowel disease

1994 • 25 citations

Aetiology of colorectal cancer: current concepts

1989 • 22 citations

Longitudinal distribution of arylamine N-acetyltransferases in the intestine of the hamster, mouse, and rat

1996 • 21 citations

More on adducts and addicts Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer Risch A, Wallace DMA, Bathers S and Sim E Human Molecular Genetics, 1995; 4: 231-236

1995 • 16 citations

Xenogenetics in multifactorial disease susceptibility

1995 • 15 citations

Effects of Heredity on Response to Drugs and Environmental Chemicals: Construction of Rodent Models

1996 • 4 citations