A new approach to risk estimation of food-borne carcinogens — heterocyclic amines — based on molecular information

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1981 • 3,794 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1983 • 3,602 citations

An Improved Bacterial Test System for the Detection and Classification of Mutagens and Carcinogens

1973 • 1,519 citations

The origin of human cancers

1981 • 653 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research

1995 • 553 citations

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1991 • 538 citations

Carcinogenic Heterocyclic Amines in Model Systems and Cooked Foods: A Review on Formation, Occurrence and Intake

1998 • 491 citations

The Maillard Reaction in Foods and Nutrition

1983 • 419 citations

The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.

1997 • 392 citations

Mutagenicities of smoke condensates and the charred surface of fish and meat

1977 • 354 citations

Carcinogenicities of heterocyclic amines in cooked food

1991 • 318 citations

ENVIRONMENTAL MUTAGENS AND CARCINOGENS

1978 • 315 citations

High concentrations of the carcinogen 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine (PhIP) occur in chicken but are dependent on the cooking method.

1995 • 269 citations

Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques

1990 • 224 citations

Selectivity of Polycyclic Inhibitors for Human Cytochrome P450s 1A1, 1A2, and 1B1

1998 • 208 citations

Prophage lambda induction of Escherichia coli K12 envA uvrB: a highly sensitive test for potential carcinogens.

1976 • 200 citations

Mutagenicities of 61 flavonoids and 11 related compounds

1981 • 192 citations

Stem cells and cellular pedigrees – a conceptual introduction

1997 • 167 citations

³²P-Postlabeling analysis of DNA adducts persisting for up to 42 weeks in the skin, epidermis and dermis of mice treated topically with 7,12-dimethylbenz[a]anthracene

1985 • 157 citations

Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

1995 • 148 citations

Creatinine and Maillard Reaction Products as Precursors of Mutagenic Compounds Formed in Fried Beef

1983 • 144 citations

Mutagenicities of protein pyrolysates

1977 • 142 citations

Mutagens in coffee and tea

1979 • 140 citations

Analysis of DNA Adducts of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Rat and Human Tissues by Alkaline Hydrolysis and Gas Chromatography/Electron Capture Mass Spectrometry: Validation by Comparison with 32P-Postlabeling

1994 • 139 citations

Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human cytochrome P4501A1, P4501A2 and P4501B1

1998 • 134 citations

High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.

1998 • 129 citations

Formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in a model system by heating creatinine, glycine and glucose

1984 • 116 citations

Test of carcinogenicity of quercetin, a widely distributed mutagen in food

1981 • 114 citations

Carcinogenic Action of N-Methyl-N′-nitro-N-nitrosoguanidine

1966 • 107 citations

Presence of N²-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues

1996 • 94 citations

Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta™Mouse)

1998 • 88 citations

Food toxicology. A perspective on the relative risks

1990 • 84 citations

DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis

1996 • 74 citations

Formation of a mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) in cooked beef, by heating a mixture containing creatinine, phenylalanine and glucose

1987 • 74 citations

ACCELERATED PAPER: Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) at the Chinese hamster hprt locus

1996 • 74 citations

³²P-Postlabeling analysis of IQ, MelQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MelQx- and PhIP-treated monkeys

1993 • 72 citations

DNA Modification by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in Rats

1989 • 71 citations

Species differences in the biotransformation of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by hepatic microsomes and cytosols from humans, rats, and mice.

1995 • 67 citations

Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents

1997 • 65 citations

Preferential induction of guanine deletion at 5′-GGGA-3′ in rat mammary glands by 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine

1999 • 61 citations

Adduct Formation at C‐8 of Guanine on in vitro Reaction f the Ultimate Form of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine with 2′‐Deoxyguanosine and Its Phosphate Esters

1992 • 58 citations

The cause of cancer

1931 • 56 citations

Organ variation in the mutagenicity of MeIQ in Big Blue® lacI transgenic mice

1996 • 55 citations

Identification of a mutagenic substance in a spice, sumac, as quercetin

1978 • 50 citations

In vitro formation and degradation of 2-amino-1-methyl-6-phenyliinidazo[4,5-b]pyridine(PhIP) protein adducts

1994 • 49 citations

Detection of Guanine‐C8‐2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine Adduct as a Single Spot on Thin‐layer Chromatography by Modification of the ³²P‐Postlabeling Method

1994 • 47 citations

Fundamentals of Cancer Prevention

2008 • 45 citations

Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene

1997 • 43 citations

Genetic analysis of PHIP intestinal mutations in Muta^TMMouse

1998 • 41 citations

Mutagenic specificity of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the supF shuttle vector system.

1994 • 41 citations

Identification of N²-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f)quinoxaline 3',5'-diphosphate, a major DNA adduct, detected by nuclease P1 modification of the ³²P-postlabeling method, in the liver of rats fed MeIQx

1993 • 41 citations

Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals.

1996 • 41 citations

Rare frequency of activation of the ki‐ras gene in rat colon tumors induced by heterocyclic amines: Possible alternative mechanisms of human colon carcinogenesis

1993 • 40 citations

History, present and future, of heterocyclic amines, cooked food mutagens.

1995 • 40 citations

Mutagens Produced by Heating Foods

1983 • 37 citations

Mutagens in Japanese pickle identified as flavonoids

1979 • 36 citations

Species differences in the N-acetylation by liver cytosol of mutagenic heterocyclic aromatic amines in protein pyrolysates

1984 • 35 citations

Identification of new mutagenic heterocyclic amines and quantification of known heterocyclic amines.

1995 • 28 citations

No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue® mice

1998 • 23 citations

DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big Blue ^TMmice does not correlate with mutagenicity

1998 • 15 citations

A new modification of the 32P-post-labeling method to recover IQDNA adducts as mononucleotides

1999 • 13 citations

Genetic determinant and environmental carcinogens

1998 • 11 citations

Lack of Carcinogenicity of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (MeIQx) in Cynomolgus Monkeys

1999 • 8 citations

Multiple Steps in Carcinogenesis, Multiple Carcinogenic Factors, and Multiple Primary Tumors: Can we Develop an Appropriate Response for Cancer Prevention?

1998 • 3 citations