Inhibition of the myeloperoxidase-H2O2-Cl− system of neutrophils by indomethacin and other non-steroidal anti-inflammatory drugs

[13] Catalase in vitro

1984 • 22,648 citations

Superoxide Dismutase

1969 • 12,578 citations

Enzyme kinetics; behavior and analysis of rapid equilibrium and steady state enzyme systems

1994 • 3,007 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

The Pharmacological Basis of Therapeutics

1986 • 2,365 citations

Enzyme Kinetics Behavior and analysis of rapid equilibrium and steady state enzyme systems

1975 • 1,447 citations

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

1982 • 1,241 citations

A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture

1980 • 1,180 citations

Active Oxygen Species and the Functions of Phagocytic Leukocytes

1980 • 1,124 citations

Studies on the chlorinating activity of myeloperoxidase.

1976 • 918 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Chlorination of Taurine by Human Neutrophils

1982 • 794 citations

Inflammation and the mechanism of action of anti‐inflammatory drugs

1987 • 523 citations

The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.

1971 • 513 citations

Cellular and extracellular myeloperoxidase in pyogenic inflammation

1982 • 487 citations

Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages—Induction by multiple nonphagocytic stimuli

1981 • 486 citations

Effects of Anti-inflammatory Drugs on Prostaglandin Biosynthesis

1972 • 478 citations

Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system.

1978 • 428 citations

New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory Drugs

1974 • 427 citations

Nonsteroidal Antiinflammatory Drugs

1980 • 398 citations

Myeloperoxidase of the leucocyte of normal human blood. I. Content and localization

1962 • 392 citations

Oxidant-induced DNA damage of target cells.

1988 • 382 citations

Brominating Oxidants Generated by Human Eosinophils

1986 • 364 citations

The Immunologic Release of Constituents from Neutrophil Leukocytes

1971 • 319 citations

Stimulation and Blockade of Prostaglandin Biosynthesis

1971 • 286 citations

Taurine Biological Actions and Clinical Perspectives

1986 • 277 citations

Inflammation: Basic Principles and Clinical Correlates

1988 • 275 citations

Myeloperoxidase-dependent effect of amines on functions of isolated neutrophils.

1983 • 257 citations

Activated neutrophils induce prolonged DNA damage in neighboring cells

1988 • 243 citations

Modes of action of aspirin-like drugs.

1985 • 218 citations

cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils.

1981 • 208 citations

Effects of non-steroidal anti-inflammatory agents on human neutrophil functions in vitro and in vivo

1984 • 182 citations

Myeloperoxidase of Human Leukaemic Leucocytes

1968 • 165 citations

Production of the superoxide adduct of myeloperoxidase (compound III) by stimulated human neutrophils and its reactivity with hydrogen peroxide and chloride

1985 • 153 citations

Diffusion of extracellular hydrogen peroxide into intracellular compartments of human neutrophils. Studies utilizing the inactivation of myeloperoxidase by hydrogen peroxide and azide.

1985 • 152 citations

Identification of distinct activation pathways of the human neutrophil NADPH-oxidase.

1986 • 148 citations

Low concentrations of indomethacin inhibit phospholipase A2 of rabbit polymorphonuclear leukocytes.

1978 • 146 citations

Mechanisms of action of anti-inflammatory drugs

1976 • 135 citations

Human Neutrophil Antimicrobial Activity

1988 • 133 citations

The halide complexes of myeloperoxidase and the mechanism of the halogenation reactions

1980 • 133 citations

[41] Cytotoxicity of chloramines

1986 • 123 citations

Inhibition of arachidonic acid cyclo-oxygenase and lipoxygenase activities of leukocytes by indomethacin and compound BW755C

1980 • 121 citations

Interaction of human .alpha.-1-proteinase inhibitor with neutrophil myeloperoxidase

1981 • 119 citations

A kinetic study of the reaction between human myeloperoxidase, hydroperoxides and cyanide inhibition by chloride and thiocyanate

1984 • 117 citations

Evidence for a role of taurine in the in vitro oxidative toxicity of neutrophils toward erythrocytes.

1985 • 116 citations

Nonsteroidal Antiinflammatory Drugs

1980 • 115 citations

The generation of utilization of chlorinated oxidants by human neutrophils

1986 • 110 citations

Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenan pleural exudates

1980 • 109 citations

A kinetic analysis of the interaction of human myeloperoxidase with hydrogen peroxide, chloride ions, and protons.

1982 • 108 citations

Immunological detection of myeloperoxidase in synovial fluid from patients with rheumatoid arthritis

1988 • 102 citations

Biologically-significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by some anti-inflammatory drugs

1987 • 87 citations

Chlorination by the Myeloperoxidase-H2O2-CI-Antimicrobial System at Acid and Neutral pH

1977 • 82 citations

Inhibition of Neutrophil Activation by Nonsteroidal Anti-Inflammatory Drugs

1984 • 74 citations

Antiarthritic drugs containing thiol groups scavenge hypochlorite and inhibit its formation by myeloperoxidase from human leukocytes. A therapeutic mechanism of these drugs in rheumatoid arthritis?

1985 • 73 citations

Piroxicam, a potent inhibitor of prostaglandin production in cell culture. Structure-activity study

1980 • 70 citations

Activation of nadph-oxidase by arachidonic acid involves phospholipase A2 in intact human neutrophils but not in the cell-free system

1986 • 70 citations

Immunologic Effects of Nonsteroidal Anti-Inflammatory Drugs

1984 • 67 citations

Taurine scavenges oxidized chlorine in biological systems.

1985 • 62 citations

Pharmacological modulation of chemotactic factor-elicited release of granule-associated enzymes from human neutrophils

1980 • 58 citations

Myeloperoxidase inactivation in the course of catalysis of chlorination of taurine

1977 • 58 citations

Inhibition by nonsteroidal anti-inflammatory drugs of superoxide production and granule enzyme release by polymorphonuclear leukocytes stimulated with immune complexes or formyl-methionyl-leucyl-phenylalanine

1987 • 57 citations

Antioxidation theory of non-steroidal anti-inflammatory drugs based upon the inhibition of luminol-enhanced chemiluminescence from the myeloperoxidase reaction

1982 • 54 citations

Differential inhibition of neutrophil superoxide generation by nonsteroidal antiinflammatory drugs

1984 • 46 citations

Rat neutrophil activation and effects of lipoxygenase and cyclooxygenase inhibitors.

1984 • 45 citations

Pharmacokinetic overview of indomethacin and sustained-release indomethacin

1985 • 44 citations

Comparison of the effects of antioxidant non-steroidal anti-inflammatory drugs against myeloperoxidase and hypochlorous acid luminol-enhanced chemiluminescence

1982 • 42 citations

Indomethacin inhibition of glutathione S-transferases

1983 • 34 citations

The effect of antiarthritic drugs and related compounds on the human neutrophil myeloperoxidase system

1982 • 24 citations

Inhibition of prostaglandin synthesis in vivo by nonsteroid anti-inflammatory drugs: Evidence for the importance of pharmacokinetics

1976 • 21 citations

Factors Determining Efficacy of NSAIDS

1984 • 18 citations

Effect of indomethacin on human neutrophil chemiluminescence and microbicidal activity

1983 • 17 citations

Superoxide generation by either 1‐oleoyl‐2‐acetylglycerol or A23187 in human neutrophils is enhanced by indomethacin

1985 • 16 citations

Effect of antiinflammatory agents on neutrophil superoxide production in rheumatoid arthritis

1984 • 12 citations

Stimulation of neutrophil oxidative metabolism by indomethacin

1985 • 8 citations

Effect of anti-rheumatic drugs on the release of lysosomal enzymes from human leukocytes.

1984 • 7 citations