Defensins

Defensins. Natural peptide antibiotics of human neutrophils.

1985 • 1,411 citations

On a remarkable bacteriolytic element found in tissues and secretions

1922 • 1,128 citations

Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity.

1989 • 695 citations

A Bactericidal Effect for Human Lactoferrin

1977 • 688 citations

A Salmonella Locus that Controls Resistance to Microbicidal Proteins from Phagocytic Cells

1989 • 556 citations

Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.

1990 • 540 citations

Primary structures of three human neutrophil defensins.

1985 • 529 citations

Direct inactivation of viruses by human granulocyte defensins

1986 • 525 citations

Bactericidal activity of human lactoferrin: sensitivity of a variety of microorganisms

1980 • 494 citations

Monocyte-chemotactic activity of defensins from human neutrophils.

1989 • 486 citations

Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes.

1978 • 466 citations

The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH

1981 • 429 citations

Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides.

1989 • 325 citations

Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes

1984 • 306 citations

Release of Gelatinase from a Novel Secretory Compartment of Human Neutrophils

1982 • 276 citations

Antibiotic proteins of human polymorphonuclear leukocytes.

1989 • 273 citations

In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes

1986 • 257 citations

Bactericidal Activity of Human Lactoferrin: Differentiation from the Stasis of Iron Deprivation

1982 • 257 citations

Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium.

1989 • 254 citations

Separation and purification of a potent bactericidal/permeability-increasing protein and a closely associated phospholipase A2 from rabbit polymorphonuclear leukocytes. Observations on their relationship.

1979 • 247 citations

Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes

1987 • 238 citations

Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils.

1985 • 234 citations

Purification and Characterization of Human Neutrophil Peptide 4, a Novel Member of the Defensin Family

1989 • 222 citations

Antibacterial activity of cationic proteins from human granulocytes.

1975 • 220 citations

Purification of three antibacterial proteins from the culture medium of NIH-Sape-4, an embryonic cell line of Sarcophaga peregrina.

1988 • 214 citations

Antibacterial and Enzymic Basic Proteins from Leukocyte Lysosomes: Separation and Identification

1963 • 207 citations

Bactericidal activity of human lysozyme, muramidase-inactive lysozyme, and cationic polypeptides against Streptococcus sanguis and Streptococcus faecalis: inhibition by chitin oligosaccharides

1985 • 203 citations

Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages.

1983 • 202 citations

Human neutrophil-specific granule deficiency: a model to assess the role of neutrophil-specific granules in the evolution of the inflammatory response

1982 • 198 citations

Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency.

1988 • 195 citations

ARGININE-RICH PROTEINS OF POLYMORPHONUCLEAR LEUKOCYTE LYSOSOMES

1968 • 195 citations

In Vitro Killing of Spores and Hyphae of Aspergillus fumigatus and Rhizopus oryzae by Rabbit Neutrophil Cationic Peptides and Bronchoalveolar Macrophages

1986 • 195 citations

Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate

1984 • 193 citations

Cationic Proteins of Polymorphonuclear Leukocyte Lysosomes II. Composition, Properties, and Mechanism of Antibacterial Action

1966 • 191 citations

Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes

1985 • 180 citations

Lactoferrin Deficiency Associated with Altered Granulocyte Function

1982 • 172 citations

Activity of rabbit leukocyte peptides against Candida albicans

1985 • 167 citations

Defensin-rich dense granules of human neutrophils

1987 • 162 citations

Determination of the disulfide array in the human defensin HNP-2

1989 • 156 citations

Phagolysosomal pH of human neutrophils

1984 • 154 citations

Microbicidal cationic proteins in rabbit alveolar macrophages: a potential host defense mechanism

1980 • 150 citations

Isolation and characterization of human defensin cDNA clones.

1988 • 145 citations

Cationic Proteins of Polymorphonuclear Leukocyte Lysosomes I. Resolution of Antibacterial and Enzymatic Activities

1966 • 142 citations

Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity.

1988 • 137 citations

Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin

1987 • 132 citations

Killing of Aspergillus spores depends on the anatomical source of the macrophage

1983 • 130 citations

Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages

1983 • 122 citations

Lysis and killing of bacteria by lysosomal proteinases

1976 • 116 citations

Purification and antimicrobial properties of three defensins from rat neutrophils

1989 • 107 citations

Solution structures of the rabbit neutrophil defensin NP-5

1988 • 105 citations

The role of lactoferrin in the bactericidal function of polymorphonuclear leucocytes.

1979 • 100 citations

Late intraphagosomal hydrogen ion concentration favors the in vitro antimicrobial capacity of a 37-kilodalton cationic granule protein of human neutrophil granulocytes

1986 • 99 citations

The structure of the rabbit macrophage defensin genes and their organ-specific expression.

1989 • 92 citations

Microbicidal mechanisms of human granulocytes: synergistic effects of granulocyte elastase and myeloperoxidase or chymotrypsin-like cationic protein

1976 • 91 citations

Structure of a novel human granulocyte peptide with anti-ACTH activity

1988 • 90 citations

Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils

1988 • 86 citations

Oxygen-independent intracellular and oxygen-dependent extracellular killing of Escherichia coli S15 by human polymorphonuclear leukocytes.

1985 • 83 citations

Microbicidal cationic proteins of rabbit alveolar macrophages: amino acid composition and functional attributes

1981 • 83 citations

Assignment of defensin gene(s) to human chromosome 8p23

1989 • 80 citations

Isolation and structure of corticostatin peptides from rabbit fetal and adult lung.

1988 • 80 citations

Purification, primary structure, and biological activity of guinea pig neutrophil cationic peptides

1989 • 80 citations

Antimicrobial Specificity of Leukocyte Lysosomal Cationic Proteins

1966 • 76 citations

Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules.

1976 • 71 citations

Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins

1988 • 68 citations

High resolution of heterogeneity among human neutrophil granules: physical, biochemical, and ultrastructural properties of isolated fractions

1986 • 66 citations

Two-dimensional NMR studies of the antimicrobial peptide NP-5

1987 • 64 citations

Subcellular location and properties of bactericidal factors from human neutrophils.

1986 • 55 citations

The corticostatic (anti-ACTH) and cytotoxic activity of peptides isolated from fetal, adult and tumor-bearing lung

1987 • 55 citations

Opsonic activity of MCP-1 and MCP-2, cationic peptides from rabbit alveolar macrophages

1985 • 53 citations

Bactericidal Activity of Specific and Azurophil Granules from Human Neutrophils: Studies with Outer-Membrane Mutants of Salmonella typhimurium LT-2

1978 • 47 citations

In Vitro Effect of Phagocyte Cationic Peptides on Coccidioides immitis

1985 • 47 citations

Increased content of microbicidal cationic peptides in rabbit alveolar macrophages elicited by complete Freund adjuvant

1981 • 46 citations

Fungicidal properties of a chymotrypsin-like cationic protein from human neutrophils: adsorption to Candida parapsilosis

1977 • 45 citations

Defensins mediate the microbicidal activity of human neutrophil granule extract against Acinetobacter calcoaceticus

1987 • 44 citations

Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2.

1985 • 43 citations

The Role of Myeloperoxidase in the Microbicidal Activity of Polymorphonuclear Leukocytes

2008 • 39 citations

Cytotoxicity of rabbit macrophage peptides MCP-1 and MCP-2 for mouse tumor cells

1985 • 34 citations

A myeloid-related sequence that localizes to human chromosome 8q21.1-22

1988 • 29 citations

Peroxidase-containing microgranules in human neutrophils: physical, morphological, cytochemical, and secretory properties

1987 • 28 citations

Characterization of two crystal forms of human defensin neutrophil cationic peptide 1, a naturally occurring antimicrobial peptide of leukocytes.

1988 • 22 citations

Killing of Proteus mirabilis by polymorphonuclear leukocyte granule proteins: evidence for species specificity by antimicrobial proteins

1988 • 15 citations

DIVERGENT EXPRESSION OF CYTOTOXIC AND MICROBICIDAL FUNCTIONS OF RABBIT ALVEOLAR AND PERITONEAL MACROPHAGES: EFFECTS OF NON‐SPECIFIC ACTIVATION AND A NATURAL MICROBICIDAL PEPTIDE, MCP‐1

1985 • 4 citations