Presence of Proteinase 3 in Secretory Vesicles: Evidence of a Novel, Highly Mobilizable Intracellular Pool Distinct From Azurophil Granules

Granules of the Human Neutrophilic Polymorphonuclear Leukocyte

1997 • 1,444 citations

Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro.

1990 • 1,214 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures.

1983 • 474 citations

Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.

1989 • 439 citations

Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters.

1988 • 436 citations

BIOCHEMICAL AND MORPHOLOGICAL CHARACTERIZATION OF AZUROPHIL AND SPECIFIC GRANULES OF HUMAN NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES

1974 • 427 citations

Control of exocytosis in early neutrophil activation.

1993 • 366 citations

Character of azurophil and specific granules purified from human polymorphonuclear leukocytes.

1974 • 340 citations

Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties

1991 • 303 citations

Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells

1989 • 293 citations

Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo

1994 • 285 citations

Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch.

1990 • 277 citations

Release of Gelatinase from a Novel Secretory Compartment of Human Neutrophils

1982 • 276 citations

Chemoattractant-Regulated Mobilization of a Novel Intracellular Compartment in Human Neutrophils

1987 • 256 citations

Interleukin‐8 processing by neutrophil elastase, cathepsin G and proteinase‐3

1994 • 238 citations

The polymorphonuclear leukocyte

1978 • 235 citations

A Large Subset of Neutrophils Expressing Membrane Proteinase 3 Is a Risk Factor for Vasculitis and Rheumatoid Arthritis

1999 • 223 citations

Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties.

1990 • 214 citations

Antimicrobial polypeptides of human neutrophils

1990 • 188 citations

Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils.

1990 • 171 citations

Ultrastructural localization of proteinase 3, the target antigen of anti-cytoplasmic antibodies circulating in Wegener's granulomatosis.

1990 • 156 citations

Bimodal distribution of proteinase 3 (PR3) surface expression reflects a constitutive heterogeneity in the polymorphonuclear neutrophil pool

1995 • 152 citations

Antimicrobial polypeptides of human neutrophils

1990 • 152 citations

Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold

1985 • 146 citations

Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis

1992 • 142 citations

Antineutrophil cytoplasmic autoantibodies: a review of the antigens involved, the assays, and the clinical and possible pathogenetic consequences

1993 • 132 citations

Proteinase 3, a Potent Secretagogue in Airways, Is Present in Cystic Fibrosis Sputum

1999 • 130 citations

Secretory vesicles are the intracellular reservoir of complement receptor 1 in human neutrophils.

1994 • 117 citations

Antineutrophil cytoplasmic autoantibodies: a review of the antigens involved, the assays, and the clinical and possible pathogenetic consequences

1993 • 116 citations

In Vitro Processing of Human Tumor Necrosis Factor-α

1995 • 114 citations

Complexes of heparin proteoglycans, chondroitin sulfate E proteoglycans, and [3H]diisopropyl fluorophosphate-binding proteins are exocytosed from activated mouse bone marrow-derived mast cells.

1986 • 106 citations

Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity

1997 • 103 citations

The heterogeneity of azurophil granules in neutrophil promyelocytes: immunogold localization of myeloperoxidase, cathepsin G, elastase, proteinase 3, and bactericidal/permeability increasing protein

1994 • 91 citations

Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro.

1996 • 86 citations

Structural and Functional Properties

1987 • 83 citations

Antineutrophil Cytoplasmic Autoantibodies Antigen Specificity

1991 • 68 citations

Platelet alpha-granule and plasma membrane share two new components: CD9 and PECAM-1

1994 • 66 citations

Comparison of Properties of Membrane Bound Versus Soluble Forms of Human Leukocytic Elastase and Cathepsin G

1994 • 63 citations

In situ localization by double-labeling immunoelectron microscopy of anti-neutrophil cytoplasmic autoantibodies in neutrophils and monocytes

1990 • 55 citations

Wegener autoantigen and myeloblastin are encoded by a single mRNA.

1991 • 44 citations

Proteinase 3. A neutrophil proteinase with activity on platelets.

1994 • 43 citations

Intracellular sites for storage and recycling of C3b receptors in human neutrophils.

1991 • 42 citations

Characterization of a recombinant proteinase 3, the autoantigen in Wegener's granulomatosis and its reactivity with anti‐neutrophil cytoplasmic autoantibodies

1996 • 26 citations

C3b receptor (CR1) on phagocytic cells from SLE patients: analysis of the defect and familial study.

1988 • 15 citations