The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

The distribution of tau in the mammalian central nervous system.

1985 • 1,518 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

1988 • 1,073 citations

Protein kinase recognition sequence motifs

1990 • 1,014 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

The Primary Structure and Heterogeneity of Tau Protein from Mouse Brain

1988 • 671 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Tau Consists of a Set of Proteins with Repeated C-Terminal Microtubule-Binding Domains and Variable N-Terminal Domains

1989 • 478 citations

Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

1990 • 298 citations

Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation.

1989 • 191 citations

Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site

1991 • 160 citations

A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope

1991 • 109 citations

Alz 50, a monoclonal antibody to Alzheimer's disease antigen, cross-reacts with tau proteins from bovine and normal human brain.

1988 • 107 citations

Location and sequence characterization of the major phosphorylation sites of the high molecular mass neurofilament proteins M and H

1987 • 103 citations

[14] Determination and location of phosphoserine in proteins and peptides by conversion to S-ethylcysteine

1991 • 102 citations

Localization of the Alz-50 epitope in recombinant human microtubule-associated protein tau

1991 • 86 citations

Abnormal tau species are produced during Alzheimer's disease neurodegenerating process

1989 • 67 citations

Mapping of the Alz 50 epitope in microtubule‐associated proteins tau

1990 • 60 citations