The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine.

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

THE SMOOTH MUSCLE CELL

1971 • 1,571 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

Nitrogen metabolism and ornithine cycle function

1990 • 556 citations

Purification and properties of a new enzyme, N, N-dimethylarginine dimethylaminohydrolase, from rat kidney

1989 • 368 citations

Synthesis of nitrite and nitrate in murine macrophage cell lines.

1987 • 335 citations

Activated macrophages kill tumour cells by releasing arginase

1978 • 307 citations

Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled.

1988 • 269 citations

Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain

1990 • 252 citations

Endothelial cells metabolize NG -monomethyl-L-arginine to L-citrulline and subsequently to L-arginine

1990 • 185 citations

Enzymes of Arginine and Urea Systhesis

1973 • 170 citations

Nitric oxide synthesis in endothelial cytosol: Evidence for a calcium-dependent and a calcium-independent mechanism

1989 • 148 citations

Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation

1989 • 126 citations

The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: L-glutamine inhibits the generation of L-arginine by cultured endothelial cells.

1990 • 125 citations

Properties of Peptidylarginine Deiminase from the Epidermis of Newborn Rats1

1981 • 116 citations

Cultured endothelial cells maintain their L-arginine level despite the continuous release of EDRF

1990 • 89 citations

Maximum activities of some key enzymes of glycolysis, glutaminolysis, Krebs cycle and fatty acid utilization in bovine pulmonary endothelial cells

1987 • 70 citations

Endothelial nitric oxide generating enzyme(s) in the bovine aorta: subcellular location and metabolic characterization.

1990 • 67 citations

L-Arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation

1989 • 66 citations

METHYLATED AMINO ACID RESIDUES OF PROTEINS OF BRAIN AND OTHER ORGANS

1975 • 57 citations

The generation of L-arginine in endothelial cells is linked to the release of endothelium-derived relaxing factor

1990 • 55 citations

Vascular activity of polycations and basic amino acids: L-arginine does not specifically elicit endothelium-dependent relaxation

1989 • 45 citations

Inhibition by <scp>l</scp>‐glutamine of the release of endothelium‐derived relaxing factor from cultured endothelial cells

1990 • 44 citations

Arginine deiminase from Mycoplasma arthritidis. Properties of the enzyme from log phase cultures.

1978 • 31 citations

Studies on Rat Liver Argininosuccinate Synthetase Inhibition by Various Amino Acids

1979 • 20 citations

Effects of ammonium ion derived from bovine endothelial cells upon low density lipoprotein degradation in cultured vascular smooth muscle cells

1985 • 5 citations