The pathogenesis of cardiovascular disease: role of the endothelium as a target and mediator

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Influence of the Internal-Mammary-Artery Graft on 10-Year Survival and Other Cardiac Events

1986 • 2,691 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

1992 • 2,138 citations

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

1990 • 1,869 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo

1995 • 1,632 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Circulating and Tissue Endothelin Immunoreactivity in Advanced Atherosclerosis

1991 • 967 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Comparative pharmacology of endothelium‐derived relaxing factor, nitric oxide and prostacyclin in platelets

1987 • 824 citations

Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension.

1990 • 803 citations

TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

1990 • 756 citations

Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension.

1993 • 685 citations

Polar secretion of endothelin-1 by cultured endothelial cells.

1992 • 650 citations

Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation

1983 • 623 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

Vasodilation to acetylcholine in primary and secondary forms of human hypertension.

1993 • 550 citations

Heterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium.

1982 • 545 citations

The Endothelium: Modulator of Cardiovascular Function

2020 • 543 citations

Difference between Endothelium-Dependent Relaxation in Arterial and in Venous Coronary Bypass Grafts

1988 • 540 citations

Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.

1990 • 527 citations

Conversion of Angiotensin I to Angiotensin II

1967 • 526 citations

Nitric Oxide Modulates the Expression of Monocyte Chemoattractant Protein 1 in Cultured Human Endothelial Cells

1995 • 475 citations

Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?

1990 • 446 citations

Endothelium-derived contracting factors.

1992 • 395 citations

Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium.

1992 • 357 citations

Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis.

1989 • 357 citations

Inhibitory Role of the Endothelium in the Response of Isolated Coronary Arteries to Platelets

1983 • 353 citations

Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide.

1991 • 331 citations

Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin.

1987 • 303 citations

Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins.

1990 • 297 citations

Preserved Endothelium-Dependent Vasodilatation in Patients with Essential Hypertension

1994 • 287 citations

Different Mechanisms of Endothelial Dysfunction With Aging and Hypertension in Rat Aorta

1995 • 287 citations

Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats.

1993 • 278 citations

Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function.

1990 • 271 citations

Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase.

1992 • 264 citations

Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris.

1991 • 243 citations

Endothelin-1 and Endothelin Receptor mRNA Expression in Normal and Atherosclerotic Human Arteries

1993 • 218 citations

Endothelin-1-induced vasoconstriction in humans. Reversal by calcium channel blockade but not by nitrovasodilators or endothelium-derived relaxing factor.

1991 • 216 citations

Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension.

1987 • 196 citations

Different activation of the endothelial L-arginine and cyclooxygenase pathway in the human internal mammary artery and saphenous vein.

1991 • 194 citations

Structural determinants of the capacity of heparin to inhibit the proliferation of vascular smooth muscle cells

1984 • 189 citations

Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein.

1989 • 185 citations

S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme.

1992 • 182 citations

Endothelin-1 in Pulmonary Hypertension Associated With High-Altitude Exposure

1995 • 168 citations

The end of the quest?

1987 • 160 citations

Endothelium-dependent regulation of the ophthalmic microcirculation in the perfused porcine eye: role of nitric oxide and endothelins.

1993 • 140 citations

Purification and characterization of a phosphoramidon-sensitive endothelin-converting enzyme in porcine aortic endothelium. OFF.

1993 • 134 citations

Increased Activity of Constitutive Nitric Oxide Synthase in Cardiac Endothelium in Spontaneous Hypertension

1995 • 127 citations

Endothelial Cells Synthesize Basic Fibroblast Growth Factor and Transforming Growth Factor Beta

1988 • 119 citations

Alterations of Vascular Reactivity in Atherosclerosis

1987 • 118 citations

Alterations of vascular reactivity in atherosclerosis.

1987 • 118 citations

Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries

1990 • 109 citations

Increased tissue endothelin immunoreactivity in atherosclerotic lesions associated with acute coronary syndromes

1994 • 101 citations

Importance of endothelium-derived nitric oxide in porcine coronary resistance arteries

1991 • 98 citations

Different interactions of platelets with arterial and venous coronary bypass vessels

1991 • 98 citations

Heterogeneity of endothelial dysfunction in hypertension

1992 • 83 citations

The endothelium in hypertension: bystander, target or mediator?

1994 • 80 citations

Endothelin-3 regulates endothelin-1 production in cultured human endothelial cells.

1991 • 78 citations

Renovascular hypertension impairs formation of endothelium‐derived relaxing factors and sensitivity to endothelin‐1 in resistance arteries

1991 • 60 citations

Structure and Function of the Rat Basilar Artery During Chronic Nitric Oxide Synthase Inhibition

1995 • 56 citations

Endothelin release is inhibited by coculture of endothelial cells with cells of vascular media

1990 • 50 citations

Gezielte Überdehnung der Aorta abdominalis am normo- und hypercholesterinaemischen Kaninchen

1963 • 43 citations

Do we need endothelin antagonists?

1993 • 36 citations

Differential Effects of the Calcium Antagonist Mibefradil in Epicardial and Intramyocardial Coronary Arteries

1995 • 31 citations