Why do omega-3 fatty acids lower serum triglycerides?

n-3 fatty acids and serum lipoproteins: human studies

1997 • 1,278 citations

Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review.

1989 • 1,152 citations

Suppression by diets rich in fish oil of very low density lipoprotein production in man.

1984 • 615 citations

n–3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored

2004 • 552 citations

Fatty Acid Regulation of Hepatic Gene Transcription

2005 • 458 citations

Fatty Acid Regulation of Gene Transcription

2004 • 358 citations

Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance

2003 • 348 citations

The adaptive effects of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver

1984 • 305 citations

Polyunsaturated Fatty Acid Suppression of Hepatic Fatty Acid Synthase and S14 Gene Expression Does Not Require Peroxisome Proliferator-activated Receptor α

1997 • 266 citations

Reduced G Protein-coupled Signaling Efficiency in Retinal Rod Outer Segments in Response to n-3 Fatty Acid Deficiency

2004 • 231 citations

Triglyceride-lowering effect of marine polyunsaturates in patients with hypertriglyceridemia.

1985 • 216 citations

Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues

1997 • 215 citations

Effects of fish oil on VLDL triglyceride kinetics in humans

1990 • 214 citations

Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats.

1993 • 204 citations

Eicosapentaenoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference

1999 • 183 citations

?3 PUFA and membrane microdomains: a new frontier in bioactive lipid research

2004 • 181 citations

Differential Gene Regulation in Human Versus Rodent Hepatocytes by Peroxisome Proliferator-activated Receptor (PPAR) α

2001 • 178 citations

Dietary Polyunsaturated Fats Uniquely Suppress Rat Liver Fatty Acid Synthase and S14 mRNA Content

1990 • 176 citations

Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism

1997 • 158 citations

Effect of Atorvastatin and Fish Oil on Plasma High-Sensitivity C-Reactive Protein Concentrations in Individuals with Visceral Obesity

2002 • 154 citations

Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content

2002 • 154 citations

Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype

2002 • 141 citations

N-3 fatty acids stimulate intracellular degradation of apoprotein B in rat hepatocytes.

1993 • 136 citations

Effects of Dietary α-Linolenic, Eicosapentaenoic and Docosahexaenoic Acids on Hepatic Lipogenesis and β-Oxidation in Rats

1998 • 132 citations

The hypotriglyceridemic effect of dietary n−3 FA is associated with increased β‐oxidation and reduced leptin expression

2003 • 131 citations

Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts

2005 • 127 citations

A diet rich in (n−3) fatty acids increases peroxisomal β-oxidation activity and lowers plasma triacylglycerols without inhibiting glutathione-dependent detoxication activities in the rat liver

1987 • 119 citations

Differential Effects of Fish Oil, Safflower Oil and Palm Oil on Fatty Acid Oxidation and Glycerolipid Synthesis in Rat Liver

1991 • 119 citations

Fish oil fatty acids impair VLDL assembly and/or secretion by cultured rat hepatocytes.

1990 • 116 citations

The hypotriglyceridemic effect of eicosapentaenoic acid in rats is reflected in increased mitochondrial fatty acid oxidation followed by diminished lipogenesis

1993 • 116 citations

Serum lipids, hepatic glycerolipid metabolism and peroxisomal fatty acid oxidation in rats fed ω-3 and ω-6 fatty acids

1992 • 114 citations

Comparative effects of dietary fish oil and carbohydrate on plasma lipids and hepatic activities of phosphatidate phosphohydrolase, diacylglycerol acyltransferase and neutral lipase activities in the rat

1987 • 81 citations

Effects of dietary purified eicosapentaenoic acid (20:5(n − 3)) and docosahexaenoic acid (22:6(n − 3)) on fatty acid desaturation and oxidation in isolated rat liver cells

1992 • 80 citations

On the effect of peroxisomal β‐oxidation and carnitine palmitoyltransferase activity by eicosapentaenoic acid in liver and heart from rats

1990 • 74 citations

Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and upregulates 2,4‐dienoyl‐CoA reductase gene expression in rats

1996 • 74 citations

Modulation of the Hypolipidemic Effect of Fish Oils by Dietary Fiber in Rats: Studies with Rice and Wheat Bran

1990 • 73 citations

Effect of dietary fish oil and corn oil on lipid metabolism and apolipoprotein gene expression by rat liver

1991 • 72 citations

Identification of shellfish fatty acids and their effects on lipogenic enzymes

1980 • 70 citations

Effects of Long-Chain Monounsaturated and n-3 Fatty Acids on Fatty Acid Oxidation and Lipid Composition in Rats

2001 • 68 citations

Dietary medium-chain fatty acids raise and (n-3) polyunsaturated fatty acids lower hepatic triacylglycerol synthesis in rats.

1995 • 64 citations

Differential Effects of Fenofibrate or Simvastatin Treatment of Rats on Hepatic Microsomal Overt and Latent Diacylglycerol Acyltransferase Activities

2002 • 61 citations

Effects of fish oil supplementation on apolipoprotein B100 production and lipoprotein metabolism in normolipidaemic males

1998 • 58 citations

Effect of n−3 fatty acids on the key enzymes involved in cholesterol and triglyceride turnover in rat liver

1991 • 57 citations

Influence of dietary fish oil on the relative synthesis of triacylglycerol and phospholipids in rat liverin vivo

1990 • 51 citations

Differential effects of eicosapentaenoic acid and oleic acid on lipid synthesis and secretion by HepG2 cells.

1991 • 49 citations

Differential effects of eicosapentaenoic acid on glycerolipid and apolipoprotein B metabolism in primary human hepatocytes compared to HepG2 cells and primary rat hepatocytes

1995 • 46 citations

Changes in fatty acid metabolism in rat hepatocytes in response to dietary n-3 fatty acids are associated with changes in the intracellular metabolism and secretion of apolipoprotein B-48

1997 • 43 citations

Triacylglycerol-rich lipoprotein margination: a potential surrogate for whole-body lipoprotein lipase activity and effects of eicosapentaenoic and docosahexaenoic acids

2004 • 40 citations

Cholesterol Consumption Alters Hepatic Sphingomyelin Metabolism in Rats1

1995 • 39 citations

Apolipoprotein B metabolism in hypertriglyceridemic diabetic patients administered either a fish oil- or vegetable oil-enriched diet

1998 • 39 citations

Dietary fish oil attenuates cardiac hypertrophy in lipotoxic cardiomyopathy due to systemic carnitine deficiency

2005 • 38 citations

Failure of insulin to stimulate lipogenesis and triacylglycerol secretion in perfused livers from rats adapted to dietary fish oil

1987 • 37 citations

Effect of dietary n−3 and n−6 polyunsaturated fatty acids on lipid‐metabolizing enzymes in obese rat liver

1994 • 37 citations

Reduction in triacylglycerol levels by fish oil correlates with free fatty acid levels inad libitum fed rats

1992 • 34 citations

Feeding pure docosahexaenoate or arachidonate decreases plasma triacylglycerol secretion in rats

1989 • 33 citations

Apparent inhibition of hepatic triacylglycerol secretion, independent of synthesis, in high-fat fish oil-fed rats: role for insulin

1991 • 32 citations

Administration of n-3 Fatty Acids in the Diets of Rats or Directly to Hepatocyte Cultures Results in Different Effects on Hepatocellular ApoB Metabolism and Secretion

1999 • 30 citations

Lipid lowering effect of omega-3 fatty acids in genetically obese zucker rats

1989 • 21 citations

Effects of dietary treatment of rats with eicosapentaenoic acid or docosahexaenoic acid on hepatic lipid metabolism

1998 • 17 citations

Concentration‐dependent effects of eicosapentaenoic acid on very low density lipoprotein secretion by the isolated perfused rat liver

1993 • 8 citations

Increased hepatic β‐oxidation of docosahexaenoic acid, elongation of eicosapentaenoic acid, and acylation of lysophosphatidate in rats fed a docosahexaenoic acid‐enriched diet

1997 • 3 citations

Regulation of gene expression and activity of malic enzyme in liver of hereditary hypertriglyceridemic (hHTG) insulin resistant rat: effect of dietary sucrose and marine fish oil.

1996 • 2 citations