Fatty Acid Regulation of Gene Transcription

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 4,142 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 3,652 citations

Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

2001 • 3,629 citations

Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease

2002 • 3,568 citations

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*

1999 • 2,880 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

Cyclooxygenase in biology and disease

1998 • 2,483 citations

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 • 2,100 citations

Nuclear Receptors and Lipid Physiology: Opening the X-Files

2001 • 2,040 citations

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

1996 • 1,987 citations

How cells read TGF-β signals

2000 • 1,843 citations

Role of LXRs in control of lipogenesis

2000 • 1,623 citations

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

2000 • 1,426 citations

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

2003 • 1,350 citations

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

2000 • 1,337 citations

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

2001 • 1,287 citations

Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers

2000 • 1,285 citations

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism

1999 • 1,260 citations

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

1999 • 1,256 citations

Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4

2001 • 1,241 citations

Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors

1999 • 1,157 citations

PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth

2001 • 1,147 citations

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

2003 • 1,075 citations

Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity

2002 • 1,066 citations

Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

2001 • 1,066 citations

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

1999 • 1,065 citations

Crucial Step in Cholesterol Homeostasis

2002 • 945 citations

Regulation of protein kinase C

1997 • 919 citations

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

2002 • 913 citations

Mechanisms of action of docosahexaenoic acid in the nervous system

2001 • 909 citations

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

1992 • 863 citations

Metabolism of highly unsaturated n-3 and n-6 fatty acids

2000 • 825 citations

Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β

2002 • 822 citations

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

1999 • 771 citations

Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors

2002 • 745 citations

Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain

2000 • 731 citations

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

1999 • 727 citations

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

1995 • 700 citations

REGULATION OF GENE EXPRESSION BY DIETARY FAT

1999 • 667 citations

Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats

1987 • 658 citations

Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c

2002 • 653 citations

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

2001 • 643 citations

Growth, Adipose, Brain, and Skin Alterations Resulting from Targeted Disruption of the Mouse Peroxisome Proliferator-Activated Receptor β(δ)

2000 • 641 citations

The Biochemistry of n-3 Polyunsaturated Fatty Acids

2002 • 628 citations

Epoxygenase Pathways of Arachidonic Acid Metabolism

2001 • 625 citations

Roles of lipid rafts in membrane transport

2001 • 623 citations

Clinical Prevention of Sudden Cardiac Death by n-3 Polyunsaturated Fatty Acids and Mechanism of Prevention of Arrhythmias by n-3 Fish Oils

2003 • 617 citations

Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion

2003 • 613 citations

Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men

2000 • 588 citations

Omega-3 Fatty Acids and Cardiovascular Disease

2003 • 583 citations

Transcriptional Repression of Atherogenic Inflammation: Modulation by PPARδ

2003 • 580 citations

Physiological compartmental analysis of α-linolenic acid metabolism in adult humans

2001 • 578 citations

Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase

2000 • 546 citations

ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose

1999 • 540 citations

Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids

2003 • 534 citations

Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action

2000 • 518 citations

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

2002 • 517 citations

n−3 Polyunsaturated fatty acids and inflammation: From molecular biology to the clinic

2003 • 507 citations

Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α

1998 • 506 citations

Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease

2003 • 505 citations

Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids

2003 • 501 citations

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

2003 • 490 citations

Selective Cooperation between Fatty Acid Binding Proteins and Peroxisome Proliferator-Activated Receptors in Regulating Transcription

2002 • 487 citations

Sterol Regulatory Element Binding Protein-1 Expression Is Suppressed by Dietary Polyunsaturated Fatty Acids

1999 • 486 citations

Fatty acid modulation of endothelial activation

2000 • 486 citations

The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus

1999 • 485 citations

Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α- and γ-mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus

2001 • 485 citations

Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR

2001 • 468 citations

Inhibition of Protein Palmitoylation, Raft Localization, and T Cell Signaling by 2-Bromopalmitate and Polyunsaturated Fatty Acids

2000 • 452 citations

Unsaturated Fatty Acids Down-regulate SREBP Isoforms 1a and 1c by Two Mechanisms in HEK-293 Cells

2001 • 438 citations

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

2002 • 430 citations

Lipid-dependent Targeting of G Proteins into Rafts

2000 • 428 citations

Dietary polyunsaturated fatty acids and regulation of gene transcription

2002 • 426 citations

Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements

2002 • 415 citations

Peroxisomal Lipid Metabolism

1994 • 414 citations

Fatty Acid Regulation of Gene Transcription

2000 • 398 citations

NF-κB inhibition by ω-3 fatty acids modulates LPS-stimulated macrophage TNF-α transcription

2003 • 397 citations

Crystal Structure of a Heterodimeric Complex of RAR and RXR Ligand-Binding Domains

2000 • 394 citations

Fish Oil Feeding Decreases Mature Sterol Regulatory Element-binding Protein 1 (SREBP-1) by Down-regulation of SREBP-1c mRNA in Mouse Liver

1999 • 375 citations

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

1999 • 364 citations

Importance of Dietary γ-Linolenic Acid in Human Health and Nutrition

1998 • 361 citations

Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism

2001 • 356 citations

Identification of a Mammalian Long Chain Fatty Acyl Elongase Regulated by Sterol Regulatory Element-binding Proteins

2001 • 342 citations

Steatohepatitis, Spontaneous Peroxisome Proliferation and Liver Tumors in Mice Lacking Peroxisomal Fatty Acyl-CoA Oxidase

1998 • 341 citations

Physiological and Nutritional Regulation of Enzymes of Triacylglycerol Synthesis

2000 • 339 citations

Polyunsaturated Eicosapentaenoic Acid Displaces Proteins from Membrane Rafts by Altering Raft Lipid Composition

2001 • 336 citations

M<scp>USCLE</scp> T<scp>RIGLYCERIDE AND</scp> I<scp>NSULIN</scp> R<scp>ESISTANCE</scp>

2002 • 333 citations

A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms

2002 • 332 citations

Nuclear receptor coregulators: multiple modes of modification

2002 • 323 citations

The SREBP pathway — insights from insigs and insects

2003 • 317 citations

Liver X Receptor-dependent Repression of Matrix Metalloproteinase-9 Expression in Macrophages

2003 • 307 citations

Peroxisome Proliferator-Activated Receptor-γ Activators Inhibit IFN-γ-Induced Expression of the T Cell-Active CXC Chemokines IP-10, Mig, and I-TAC in Human Endothelial Cells

2000 • 300 citations

Hepatocyte Nuclear Factor 4 Is a Transcription Factor that Constitutively Binds Fatty Acids

2002 • 297 citations

Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids.

1994 • 297 citations

Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2

1995 • 294 citations

Do Long-Chain Acyl-CoA Synthetases Regulate Fatty Acid Entry into Synthetic Versus Degradative Pathways?

2002 • 293 citations

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor

2001 • 288 citations

Role of stearoyl-coenzyme A desaturase in lipid metabolism

2003 • 287 citations

Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis

2003 • 285 citations

Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα

2002 • 285 citations

Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression

2002 • 282 citations

Premenopausal Fat Intake and Risk of Breast Cancer

2003 • 280 citations

Activation of the Nuclear Factor-κB Is a Key Event in Brain Tolerance

2001 • 275 citations

Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay

2001 • 271 citations

Crystal Structure of the HNF4α Ligand Binding Domain in Complex with Endogenous Fatty Acid Ligand

2002 • 270 citations

Effect of hydrogenated and saturated, relative to polyunsaturated, fat on immune and inflammatory responses of adults with moderate hypercholesterolemia

2002 • 266 citations

Polyunsaturated Fatty Acid Suppression of Hepatic Fatty Acid Synthase and S14 Gene Expression Does Not Require Peroxisome Proliferator-activated Receptor α

1997 • 266 citations

The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism

2002 • 261 citations

Modulation of Inflammation and Cytokine Production by Dietary (n-3) Fatty Acids

1996 • 260 citations

Recent insights into stearoyl-CoA desaturase-1

2003 • 259 citations

Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes

2000 • 256 citations

Polyunsaturated Fatty Acids Inhibit T Cell Signal Transduction by Modification of Detergent-insoluble Membrane Domains

1998 • 254 citations

Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene

2000 • 254 citations

Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands

2001 • 240 citations

Dietary Fatty Acids and the Regulation of Plasma Low Density Lipoprotein Cholesterol Concentrations ,

1998 • 235 citations

Regulated Expression of the Apolipoprotein E/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages

2002 • 230 citations

Fish Oil Decreases Macrophage Tumor Necrosis Factor Gene Transcription by Altering the NFκB Activity

1999 • 229 citations

Fatty acid transport proteins: a current view of a growing family

2001 • 227 citations

Unsaturated Fatty Acids Inhibit Cholesterol Efflux from Macrophages by Increasing Degradation of ATP-binding Cassette Transporter A1

2002 • 224 citations

Fibrates down-regulate IL-1–stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB–C/EBP-β complex formation

2002 • 222 citations

Depression and bipolar disorder: relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing and osteoporosis Possible candidate genes

1999 • 222 citations

The Role of Docosahexaenoic Acid Containing Phospholipids in Modulating G Protein-Coupled Signaling Pathways: Visual Transduction

2001 • 212 citations

Prostaglandin E2 Induces Hypoxia-inducible Factor-1α Stabilization and Nuclear Localization in a Human Prostate Cancer Cell Line

2002 • 212 citations

Identification of Two Mammalian Reductases Involved in the Two-carbon Fatty Acyl Elongation Cascade

2003 • 211 citations

Fatty Acids and Immune Responses—A New Perspective in Searching for Clues to Mechanism

2000 • 208 citations

Identification and expression of mammalian long‐chain PUFA elongation enzymes

2002 • 207 citations

Role of a New Mammalian Gene Family in the Biosynthesis of Very Long Chain Fatty Acids and Sphingolipids

2000 • 207 citations

X-ray Crystal Structure of the Liver X Receptor β Ligand Binding Domain

2003 • 203 citations

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs

2002 • 197 citations

Sterol Regulatory Element-binding Protein Negatively Regulates Microsomal Triglyceride Transfer Protein Gene Transcription

1999 • 197 citations

Sterol Response Element-binding Protein 1c (SREBP1c) Is Involved in the Polyunsaturated Fatty Acid Suppression of Hepatic S14 Gene Transcription

1999 • 196 citations

Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-δ

2002 • 193 citations

Dietary fat and cancer

2002 • 192 citations

Unsaturated Fatty Acid Regulation of Peroxisome Proliferator-activated Receptor α Activity in Rat Primary Hepatoctes

2003 • 189 citations

Troglitazone Antagonizes Tumor Necrosis Factor-α-induced Reprogramming of Adipocyte Gene Expression by Inhibiting the Transcriptional Regulatory Functions of NF-κB

2003 • 187 citations

Docosahexaenoic Acid Selectively Attenuates Induction of Vascular Cell Adhesion Molecule–1 and Subsequent Monocytic Cell Adhesion to Human Endothelial Cells Stimulated by Tumor Necrosis Factor–α

1995 • 187 citations

Cross-Talk between Fatty Acid and Cholesterol Metabolism Mediated by Liver X Receptor-α

2000 • 187 citations

Nuclear Factor kB Is Activated by Arachidonic Acid but Not by Eicosapentaenoic Acid

1996 • 185 citations

Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle

2003 • 182 citations

The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse

2003 • 181 citations

Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells.

2003 • 179 citations

Dietary Polyunsaturated Fats Uniquely Suppress Rat Liver Fatty Acid Synthase and S14 mRNA Content

1990 • 176 citations

Nutritional modulation of cytokine biology

1998 • 176 citations

Peroxisome Proliferator-activated Receptor γ Inhibits Transforming Growth Factor β-induced Connective Tissue Growth Factor Expression in Human Aortic Smooth Muscle Cells by Interfering with Smad3

2001 • 173 citations

Cognitive deficits in docosahexaenoic acid-deficient rats.

2002 • 165 citations

Long-chain omega 3 fatty acids, blood lipids and cardiovascular risk reduction

2001 • 164 citations

The Phospholipid Transfer Protein Gene Is a Liver X Receptor Target Expressed by Macrophages in Atherosclerotic Lesions

2003 • 161 citations

Cognitive deficits in docosahexaenoic acid-deficient rats.

2002 • 156 citations

Negative Regulation of Human Fibrinogen Gene Expression by Peroxisome Proliferator-activated Receptor α Agonists via Inhibition of CCAAT Box/Enhancer-binding Protein β

2001 • 155 citations

Activity and mRNA levels of enzymes involved in hepatic fatty acid synthesis and oxidation in mice fed conjugated linoleic acid

2003 • 153 citations

Regulation of human Δ-6 desaturase gene transcription: identification of a functional direct repeat-1 element

2003 • 151 citations

The Role of Liver X Receptor-α in the Fatty Acid Regulation of Hepatic Gene Expression

2003 • 149 citations

Effect of dietary n − 3 and n − 6 fatty acids on fatty acid desaturation in rat liver

1991 • 149 citations

Polyunsaturated fatty acids inhibit S14 gene transcription in rat liver and cultured hepatocytes.

1993 • 146 citations

In contrast with docosahexaenoic acid, eicosapentaenoic acid and hypolipidaemic derivatives decrease hepatic synthesis and secretion of triacylglycerol by decreased diacylglycerol acyltransferase activity and stimulation of fatty acid oxidation

1999 • 142 citations

Inhibition of protein kinase C by cationic amphiphiles

1992 • 138 citations

n−3 Fatty acid deficiency decreases phosphatidylserine accumulation selectively in neuronal tissues

2000 • 131 citations

Involvement of the peroxisome proliferator-activated receptor alpha in the immunomodulation caused by peroxisome proliferators in mice

2002 • 131 citations

Enhancement of G protein‐coupled signaling by DHA phospholipids

2003 • 125 citations

Activity of human Δ5 and Δ6 desaturases on multiple n‐3 and n‐6 polyunsaturated fatty acids

2001 • 122 citations

Structure of Eicosapentaenoic and Linoleic Acids in the Cyclooxygenase Site of Prostaglandin Endoperoxide H Synthase-1

2001 • 122 citations

Optimization of Receptor-G Protein Coupling by Bilayer Lipid Composition I

2001 • 119 citations

Regulation of the Uncoupling Protein-2 Gene in INS-1 β-Cells by Oleic Acid

2002 • 119 citations

Polyunsaturated Fatty Acid Regulation of Gene Expression

2001 • 117 citations

Fish oil fatty acids impair VLDL assembly and/or secretion by cultured rat hepatocytes.

1990 • 116 citations

Fatty acid—Mediated activation of vascular endothelial cells

2000 • 114 citations

Regulation of the Rat SREBP-1c Promoter in Primary Rat Hepatocytes

2002 • 112 citations

Selective inhibitors of cytosolic or secretory phospholipase A2 block TNF-induced activation of transcription factor nuclear factor-kappa B and expression of ICAM-1.

1998 • 112 citations

Cig30, a Mouse Member of a Novel Membrane Protein Gene Family, Is Involved in the Recruitment of Brown Adipose Tissue

1997 • 109 citations

Orphan receptor HNF-4 and liver-specific gene expression.

1993 • 108 citations

Optimization of Receptor-G Protein Coupling by Bilayer Lipid Composition II

2001 • 106 citations

Analysis of protein dimerization and ligand binding of orphan receptor HNF4α

2000 • 104 citations

Unsaturated Fatty Acid-mediated Decreases in Sterol Regulatory Element-mediated Gene Transcription Are Linked to Cellular Sphingolipid Metabolism

2002 • 103 citations

The E-box like sterol regulatory element mediates the suppression of human Δ-6 desaturase gene by highly unsaturated fatty acids

2002 • 100 citations

D<scp>IETARY</scp>R<scp>EGULATION OF</scp>E<scp>XPRESSION OF</scp>G<scp>LUCOSE</scp>-6-P<scp>HOSPHATE</scp>D<scp>EHYDROGENASE</scp>

2001 • 99 citations

Sterol Regulatory Element-binding Protein-1c Mimics the Negative Effect of Insulin on Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription

2001 • 94 citations

Factorial study of the effects of atorvastatin and fish oil on dyslipidaemia in visceral obesity

2002 • 93 citations

Selective Inhibitors of Cytosolic or Secretory Phospholipase A2 Block TNF-Induced Activation of Transcription Factor Nuclear Factor-κB and Expression of ICAM-1

1998 • 89 citations

Differential Modulation of ACAT1 and ACAT2 Transcription and Activity by Long Chain Free Fatty Acids in Cultured Cells

2001 • 88 citations

Identification and Expression of a Rat Fatty Acid Elongase Involved in the Biosynthesis of C18 Fatty Acids

2002 • 84 citations

Cardiovascular disease and long-chain omega-3 fatty acids

2003 • 84 citations

Fatty acids, triglycerides and syndromes of insulin resistance

1997 • 84 citations

Peroxisome Proliferator-activated Receptor α Inhibits Hepatic S14 Gene Transcription

1996 • 84 citations

The Murine and Human Cholesterol 7α-Hydroxylase Gene Promoters Are Differentially Responsive to Regulation by Fatty Acids Mediated via Peroxisome Proliferator-activated Receptor α

2000 • 83 citations

Fatty Acid Regulation of Liver X Receptors (LXR) and Peroxisome Proliferator-activated Receptor α (PPARα) in HEK293 Cells

2002 • 82 citations

Effects of atorvastatin and omega-3 fatty acids on LDL subfractions and postprandial hyperlipemia in patients with combined hyperlipemia.

2001 • 78 citations

Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro

2001 • 78 citations

Ligand Specificity and Conformational Dependence of the Hepatic Nuclear Factor-4α (HNF-4α)

2002 • 76 citations

Minireview: Genomics Versus Orphan Nuclear Receptors—A Half-Time Report

2002 • 76 citations

Dietary fats modulate the regulatory potential of dietary cholesterol on cholesterol 7 alpha-hydroxylase gene expression

1997 • 76 citations

Identification of a fatty acid Δ6-desaturase deficiency in human skin fibroblasts

2001 • 75 citations

Role of Cyclooxygenase 2 in Protein Kinase C βII-mediated Colon Carcinogenesis

2003 • 73 citations

Suppression of hepatocyte nuclear factor-4α by acyl-CoA thioesters of hypolipidemic peroxisome proliferators

2001 • 72 citations

Protein kinase C βII and TGFβRII in ω-3 fatty acid–mediated inhibition of colon carcinogenesis

2002 • 71 citations

PPARα Inhibits TGF-β–Induced β ₅ Integrin Transcription in Vascular Smooth Muscle Cells by Interacting With Smad4

2002 • 66 citations

Arachidonic acid and PGE2 regulation of hepatic lipogenic gene expression

1999 • 66 citations

Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids

2000 • 64 citations

Functional characterization of the MODY1 gene mutations HNF4(R127W), HNF4(V255M), and HNF4(E276Q).

1999 • 59 citations

Linoleic acid-stimulated vascular adhesion molecule-1 expression in endothelial cells depends on nuclear factor-[kappa ]B activation

2002 • 59 citations

Evidence against the peroxisome proliferator-activated receptor α (PPARα) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription

2000 • 55 citations

Different effects of n-6 and n-3 polyunsaturated fatty acids on the activation of rat smooth muscle cells by interleukin-1β

2003 • 51 citations

Mechanism of a Transcriptional Cross Talk between Transforming Growth Factor-β–regulated Smad3 and Smad4 Proteins and Orphan Nuclear Receptor Hepatocyte Nuclear Factor-4

2003 • 51 citations

Isolation and characterization of two distinct forms of liver fatty acid binding protein from the rat

1999 • 49 citations

Dietary polyunsaturated fatty acids and hepatic gene expression

1999 • 48 citations

Delayed induction of Δ-6 and Δ-5 desaturases by a peroxisome proliferator

2002 • 43 citations

Selective Proteolytic Processing of Rat Hepatic Sterol Regulatory Element Binding Protein-1 (SREBP-1) and SREBP–2 During Postnatal Development

2003 • 41 citations

SMAD Proteins Transactivate the Human ApoCIII Promoter by Interacting Physically and Functionally with Hepatocyte Nuclear Factor 4

2000 • 41 citations

Elovl4 mRNA distribution in the developing mouse retina and phylogenetic conservation of Elovl4 genes.

2003 • 41 citations

Straight-Chain Acyl-CoA Oxidase Knockout Mouse Accumulates Extremely Long Chain Fatty Acids from α-Linolenic Acid: Evidence for Runaway Carousel-Type Enzyme Kinetics in Peroxisomal β-Oxidation Diseases

2002 • 41 citations

Functional Interaction between Sterol Regulatory Element-binding Protein-1c, Nuclear Factor Y, and 3,5,3′-Triiodothyronine Nuclear Receptors

2001 • 40 citations

Arachidonic acid suppression of fatty acid synthase gene expression in cultured rat hepatocytes

1991 • 40 citations

A nucleotide insertion in the transcriptional regulatory region of FADS2 gives rise to human fatty acid delta-6-desaturase deficiency

2003 • 38 citations

Dietary n − 3 fatty acids accelerate catabolism of leukotriene B4 in human granulocytes

1993 • 37 citations

Dietary fatty acids and coronary heart disease

1999 • 32 citations

Metabolism of polyunsaturated (n − 3) fatty acids by monkey seminal vesicles: isolation and biosynthesis of omega-3 epoxides

1991 • 32 citations

Williams, S. et al. X-ray crystal structure of the liver X receptor ligand binding domain: regulation by a histidine-tryptophan switch. J. Biol. Chem. 278, 27138-27143

2003 • 29 citations

Lipids in vascular function

1999 • 25 citations

Metabolism of Cholesterol Is Altered in the Liver of C3H Mice Fed Fats Enriched with Different C-18 Fatty Acids

1999 • 22 citations

Desperately Seeking…Something

2002 • 22 citations

DOCOSAHEXAENOIC ACID DECREASES IRF-1 mRNA AND THUS INHIBITS ACTIVATION OF BOTH THE IRF-E AND NF??d RESPONSE ELEMENTS OF THE iNOS PROMOTER12

2000 • 21 citations

Fatty acid composition of phospholipids, triglycerides and cholesterol in serum of castrated and estradiol treated rats

2000 • 19 citations

Omega-3 Fatty Acids: Implications for the Treatment of Tumor-Associated Inflammation

2003 • 18 citations

Tissue specificity of S14 and fatty acid synthase invitro transcription

1992 • 11 citations

Cig30 and Pitx3 Genes Are Arranged in a Partially Overlapping Tail-to-Tail Array Resulting in Complementary Transcripts

1999 • 10 citations

Fatty acid desaturation: effect of alphafetoprotein on alpha-linolenic acid conversion by fetal rat hepatocytes

1999 • 10 citations

Effects of fructose and troglitazone on phospholipid fatty acid composition in rat skeletal muscle

2000 • 7 citations

Elovl1 and p55Cdc Genes Are Localized in a Tail-to-Tail Array and Are Co-expressed in Proliferating Cells

2002 • 7 citations

(Lipids, 37:733-740)Identification and expression of mammalian very long-chain PUFA elongation enzymes

2002 • 5 citations

(Biochem. J., 350:765-770)Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids

2000 • 5 citations