Immunomodulatory effects of interferon-β-1b in patients with multiple sclerosis

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Rating neurologic impairment in multiple sclerosis

1983 • 14,011 citations

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

A membrane-filter technique for the detection of complementary DNA

1966 • 3,996 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 2,032 citations

Transforming growth factor beta

2011 • 1,990 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 1,908 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.

1988 • 988 citations

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists.

1993 • 837 citations

Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β

1989 • 785 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells

1992 • 653 citations

Tumor necrosis factor.

1992 • 601 citations

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

1986 • 579 citations

Induction of β2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferation

1986 • 577 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

A Chemoattractant Receptor Controls Development in Dictyostelium discoideum

1988 • 465 citations

Shedding of tumor necrosis factor receptors by activated human neutrophils.

1990 • 443 citations

Multiple Sclerosis

1982 • 415 citations

Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.

1990 • 369 citations

Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

1996 • 363 citations

Tumor necrosis factor‐α messenger RNA expression in patients with relapsing‐remitting multiple sclerosis is associated with disease activity

1995 • 336 citations

Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

1996 • 302 citations

Transforming Growth Factor β

1988 • 295 citations

The Dale E. McFarlin memorial lecture: The immunology of the multiple sclerosis lesion

1994 • 284 citations

Interferon β decreases T cell activation and interferon γ production in multiple sclerosis

1993 • 264 citations

Suppressor cell function in multiple sclerosis: Correlation with clinical disease activity

1979 • 251 citations

Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis

1994 • 227 citations

Antagonistic effect of interferon-beta on the interferon-gamma-induced expression of Ia antigen in murine macrophages.

1985 • 207 citations

Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I

1995 • 177 citations

Increased transforming growth factor‐β, interleukin‐4, and interferon‐γ in multiple sclerosis

1994 • 162 citations

Increases in soluble VCAM‐1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon β‐1b

1997 • 155 citations

INTERFERONS

1989 • 153 citations

Circulating adhesion molecules and tumor necrosis factor receptor in multiple sclerosis: Correlation with magnetic resonance imaging

1995 • 150 citations

Subunit structure of a high-affinity receptor for type beta-transforming growth factor. Evidence for a disulfide-linked glycosylated receptor complex.

1985 • 139 citations

Molecular Cloning and Expression of Human and Rat Tumor Necrosis Factor Receptor Chain (p60) and Its Soluble Derivative, Tumor Necrosis Factor-Binding Protein

1990 • 135 citations

Recombinant Interferon-β blocks proliferation but enhances interleukin-10 secretion by activated human T-cells

1996 • 122 citations

Interfer beta augments supperssor cell function in multiple sclerosis

1990 • 120 citations

VLA-4 expression on peripheral blood lymphocytes is downregulated after treatment of multiple sclerosis with interferon beta

1997 • 119 citations

Adhesion of lymphocytes to cerebral microvascular cells: effects of interferon-gamma, tumour necrosis factor and interleukin-1.

1988 • 119 citations

Interferon-beta sub 1b treatment decreases tumor necrosis factor-alpha and increases interleukin-6 production in multiple sclerosis

1996 • 119 citations

MYOPATHIES: THE NEUROGENIC HYPOTHESIS?

1974 • 118 citations

Interferon (IFN)-β treatment enhances CD95 and interleukin 10 expression but reduces interferon-γ producing T cells in MS patients

1999 • 114 citations

Circulating, soluble adhesion proteins in cerebrospinal fluid and serum of patients with multiple sclerosis: Correlation with clinical activity

1995 • 111 citations

Activated suppressor cell dysfunction in progressive multiple sclerosis.

1986 • 103 citations

Interferon effects on interleukin-10 secretion Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients

1995 • 103 citations

Tumor necrosis factor-alpha and tumor necrosis factor-beta (lymphotoxin) stimulate the production of granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in vivo.

1988 • 97 citations

Effects of growth factors on the antiproliferative activity of tumor necrosis factors.

1987 • 96 citations

Influence of interferon β-1a dose frequency on PBMC cytokine secretion and biological effect markers

1999 • 95 citations

Phosphorylation-dependent Interaction of the Cytoplasmic Domains of the Type I and Type II Transforming Growth Factor-β Receptors

1995 • 80 citations

Blood levels of transforming growth factor-beta 1 (TGF-β1) are elevated in both relapsing remitting and chronic progressive multiple sclerosis (MS) patients and are further augmented by treatment with interferon-beta 1b (IFN-β1b)

1998 • 78 citations

Suppressor cell function in multiple sclerosis.

1978 • 67 citations

Interferon Beta in Multiple Sclerosis

1996 • 63 citations

Immunoregulatory effects of interferon-β and interacting cytokines on human vascular endothelial cells implications for multiple sclerosis and other autoimmune diseases

1996 • 62 citations

Tumour necrosis factor-alpha and other cytokines in Guillain-Barre syndrome.

1994 • 62 citations

Differential effects of beta and gamma interferons on expression of major histocompatibility complex antigens and intercellular adhesion molecule‐1 in cultured fetal human astrocytes

1995 • 60 citations

Interferon β-1b effects on cytokine mRNA in peripheral mononuclear cells in multiple sclerosis

1996 • 57 citations

Organ‐specific autoantigens induce transforming growth factor‐β mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis

1994 • 57 citations

Increased levels of soluble vascular cell adhesion molecule-1 ( VCAM-1) in the cerebrospinal fluid and sera of patients with multiple sclerosis and human T lymphotropic virus type-1-associated myelopathy

1995 • 53 citations

Interferon-β downregulates interferon-γ-induced class II MHC molecule expression and morphological changes in primary cultures of human brain microvessel endothelial cells

1995 • 51 citations

Type I interferons (IFN-α and -β) suppress cytotoxin (tumor necrosis factor-α and lymphotoxin) production by mitogen-stimulated human peripheral blood mononuclear cells

1992 • 51 citations

Reduction of both pro- and anti-inflammatory cytokines after 6 months of interferon beta-1a treatment of multiple sclerosis

2000 • 51 citations

Role of cytokines in multiple sclerosis and experimental autoimmune encephalomyelitis

1994 • 50 citations

Suppression of immune cell function in vitro by recombinant human transforming growth factor-β

1988 • 48 citations

Pathogenesis of inflammatory demyelination

1995 • 41 citations

Comparison of the effects of oral versus intravenous methylprednisolone regimens on peripheral blood T lymphocyte adhesion molecule expression, T cell subsets distribution and TNF alpha concentrations in multiple sclerosis

1997 • 36 citations

Interferon β Modulates Experimental Autoimmune Encephalomyelitis by Altering the Pattern of Cytokine Secretion

1999 • 36 citations

Interferon beta-1b treatment modulates TNFα and IFNγ spontaneous gene expression in MS

1999 • 33 citations

Potential role of transforming growth factor-?1 in terminating the immune response in patients with Guillain-Barr� syndrome

1996 • 28 citations

Therapeutic effect of transforming growth factor-beta 2 on actively induced EAN but not adoptive transfer EAN.

1994 • 24 citations

Detection of transforming growth factor beta1 mRNA in cerebrospinal fluid cells of patients with meningitis by non-radioactive in situ hybridization

1994 • 21 citations

Influence of IFN‐β1b (Betaferon) on cytokine mRNA profiles in blood mononuclear cells and plasma levels of soluble VCAM‐1 in multiple sclerosis

1998 • 20 citations

Interferon beta normalizes suppressor cell function in dysimmune neuropathies

1998 • 19 citations

Corticosteroids induce expression of transforming-growth-factor-beta1 mRNA in peripheral blood mononuclear cells of patients with multiple sclerosis

1998 • 18 citations

Influence of serum on zinc, toxic shock syndrome toxin-1, and lipopolysaccharide-induced production of IFN-γ and IL-1β by human mononuclear cells

1995 • 18 citations

Immunological effects of in vivo interferon-β 1b treatment in ten patients with multiple sclerosis: a 1-year follow-up

1999 • 15 citations

Transforming-Growth-Factor β: Wirkungsweise und klinische Bedeutung^*

2008 • 10 citations

IFN β-1b reverses elevated lymphocyte B7-1 in MS

1995 • 5 citations