Organ‐specific autoantigens induce transforming growth factor‐β mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS

1965 • 1,402 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values

1977 • 867 citations

Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values

1977 • 779 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Studies in myasthenia gravis: review of a twenty-year experience in over 1200 patients.

1971 • 647 citations

Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry

1992 • 588 citations

Role of Cytokines and CD4+ T‐Cell Subsets in the Regulation of Parasite Immunity and Disease

1989 • 405 citations

Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice.

1991 • 400 citations

Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1.

1991 • 385 citations

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

1990 • 363 citations

Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals

1990 • 332 citations

[29] Production and assay of antibodies to acetylcholine receptors

1981 • 277 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

Improved detection of oligoclonal IgG in cerebrospinal fluid by isoelectric focusing in agarose, double-antibody peroxidase labeling, and avidin-biotin amplification.

1984 • 199 citations

CD4+ suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta.

1991 • 175 citations

Transforming growth factor-beta inhibits the generation of cytotoxic T cells in virus-infected mice.

1989 • 164 citations

Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis

1992 • 163 citations

Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis

1992 • 117 citations

Acetylcholine receptor-reactive T and B cells in myasthenia gravis and controls.

1991 • 108 citations

Transforming growth factors type β1 and β2 suppress rat astrocyte autoantigen presentation and antagonize hyperinduction of class II major histocompatibility complex antigen expression by interferon-γ and tumor necrosis factor-α

1990 • 99 citations

Transforming growth factors β1 and β2: cytokines with identical immunosuppressive effects and a potential role in the regulation of autoimmune T cell function

1989 • 84 citations

Virus-reactive and autoreactive T cells are accumulated in cerebrospinal fluid in multiple sclerosis

1992 • 81 citations

Chronic experimental allergic encephalomyelitis produced by bovine proteolipid apoprotein: Immunological studies in rabbits

1983 • 76 citations

Chronic experimental allergic encephalomyelitis in guinea pigs induced by proteolipid protein

1985 • 75 citations

Transforming growth factor-beta modulates T cell-mediated encephalitis caused by Borna disease virus. Pathogenic importance of CD8+ cells and suppression of antibody formation.

1991 • 61 citations

Transforming growth factor-β in the regulation of the immune response

1992 • 60 citations

Persistent anti-myelin basic protein IgG antibody response in multiple sclerosis cerebrospinal fluid

1990 • 56 citations

T Cells Recognizing Multiple Peptides of Myelin Basic Protein are Found in Blood and Enriched in Cerebrospinal Fluid in Optic Neuritis and Multiple Sclerosis

1993 • 43 citations

Purification of proteolipid protein and production of specific antiserum

1986 • 38 citations

IL-4: Structure and Function

1992 • 33 citations