Interferon β decreases T cell activation and interferon γ production in multiple sclerosis

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.

1986 • 532 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

1991 • 434 citations

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?

1988 • 404 citations

Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and -independent binding mechanisms.

1991 • 398 citations

SERIAL GADOLINIUM ENHANCED MAGNETIC RESONANCE IMAGING IN MULTIPLE SCLEROSIS

1988 • 397 citations

In Vivo Activated T Lymphocytes in the Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis

1985 • 307 citations

Serial magnetic resonance scanning in multiple sclerosis: A second prospective study in relapsing patients

1989 • 251 citations

Expression of Gene rrg Is Associated with Reversion of NIH 3Tt3 Transformed by LTR-c-H- ras

1990 • 224 citations

Antagonistic effect of interferon-beta on the interferon-gamma-induced expression of Ia antigen in murine macrophages.

1985 • 207 citations

Intrathecal Interferon Reduces Exacerbations of Multiple Sclerosis

1981 • 205 citations

Heterogeneity of blood‐brain barrier changes in multiple sclerosis

1990 • 201 citations

Effect of cloned interferon‐γ on expression of H‐2 and Ia antigens on cell lines of hemopoietic, lymphoid, epithelial, fibroblastic and neuronal origin

1984 • 192 citations

Multiple sclerosis: Involvement of interferons in lesion pathogenesis

1988 • 188 citations

Multiple sclerosis

1988 • 186 citations

Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis.

1987 • 163 citations

Interferon-gamma regulates an antigen specific for endothelial cells involved in lymphocyte traffic.

1986 • 145 citations

Three distinct classes of regulatory cytokines control endothelial cell MHC antigen expression. Interactions with immune gamma interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte alpha and fibroblast beta interferons.

1988 • 142 citations

Contrasting effect of alpha/beta- and gamma-interferons on expression of macrophage Ia antigens.

1986 • 138 citations

Systemic alpha‐interferon therapy of multiple sclerosis

1984 • 128 citations

Interfer beta augments supperssor cell function in multiple sclerosis

1990 • 120 citations

Tumor necrosis factor-α enhances interferon-γ-mediated class II antigen expression on astrocytes

1989 • 118 citations

Detection of in Vivo Stimulated Cerebrospinal-Fluid Lymphocytes by Flow Cytometry in Patients with Multiple Sclerosis

1980 • 111 citations

Interferon-β impairs induction of HLA-DR antigen expression in cultured adult human astrocytes

1989 • 98 citations

Inhibitory effects of interferon on the expression of genes regulated by platelet-derived growth factor.

1985 • 97 citations

The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: evidence for a key role of activated lymphocytes.

1985 • 97 citations

Interferon responses of leukocytes in multiple sclerosis

1981 • 95 citations

Lymphocytes from multiple sclerosis patients produce elevated levels of gamma interferonin vitro

1985 • 94 citations

Two subsets of human CD4⁺T helper cells differing in kinetics and capacities to produce interleukin 2 and interferon‐γ can be defined by the Leu‐18 and UCHLl monoclonal antibodies

1988 • 94 citations

The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions.

1988 • 82 citations

Intrathecally Administered Natural Human Fibroblast Interferon Reduces Exacerbations of Multiple Sclerosis

1987 • 79 citations

Systemic lymphoblastoid interferon therapy in chronic progressive multiple Sclerosis. I. Clinical and MRI evaluation

1990 • 77 citations

Cytotoxic activity and interferon production by lymphocytes from patients with multiple sclerosis.

1981 • 74 citations

Systemic Recombinant -2Interferon Therapy in Relapsing Multiple Sclerosis

1986 • 73 citations

Biochemical correlates of phenotypic reversion in interferon-treated mouse cells transformed by a human oncogene

1984 • 71 citations

Differential effect of interferon on DNA synthesis, 2‐deoxyglucose uptake and ornithine decarboxylase activity in 3T3 cells stimulated by polypeptide growth factors and tumor promotors

1980 • 66 citations

Differential Effects of Recombinant Interferons , beta, and on Induction of Human Lymphokine (IL-2)-Activated Killer Activity

1988 • 62 citations

Activated T lymphocytes in patients with multiple sclerosis

1983 • 51 citations

Contrasting effects of alpha, beta, and gamma interferons on nonspecific suppressor function in multiple sclerosis

1992 • 44 citations

Systemic α-Interferon in Multiple Sclerosis

1987 • 44 citations

Intrathecal Interferon in the Treatment of Multiple Sclerosis

1985 • 41 citations

Inhibition of ornithine decarboxylase in human fibroblast cells by type I and type II interferons

1983 • 37 citations

Further Lymphocyte Characterization in the Central Nervous System in Multiple Sclerosis^a

1984 • 33 citations

Multiple sclerosis: Activated cells in cerebrospinal fluid in acute exacerbations

1985 • 28 citations

Preferential increase of IL-2R+ CD4+ T cells and CD45RB− CD4+ T cells in the central nervous system in experimental allergic encephalomyelitis

1992 • 21 citations

Interferon production by lymphocytes from multiple sclerosis and non‐MS patients

1983 • 21 citations

Interferon production by cultured peripheral leucocytes of MS patients.

1984 • 19 citations

Interferon induction, 2′-5′ oligo A synthetase and lymphocyte subpopulations in out-patients with multiple sclerosis in a longitudinal study

1986 • 8 citations

Suppressive effects of mouse interferon-beta on gene expression occurring in concanavalin A-stimulated mouse spleen cells.

1988 • 4 citations

Interferons modulate immune function in MS

1991 • 1 citations