The role of regulatory T cells in neurodegenerative diseases

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo

2005 • 5,087 citations

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Non-coding RNAs in human disease

2011 • 4,430 citations

Systems Biology: A Brief Overview

2002 • 4,071 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

2010 • 3,305 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Mechanisms Underlying Inflammation in Neurodegeneration

2010 • 3,161 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

2008 • 2,656 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Human nutrition, the gut microbiome and the immune system

2011 • 2,387 citations

FOXP3+ regulatory T cells in the human immune system

2010 • 2,283 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

IMMUNOLOGY OF MULTIPLE SCLEROSIS

2005 • 2,099 citations

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

2009 • 1,959 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

2009 • 1,688 citations

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

2008 • 1,611 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

2006 • 1,496 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Role of LAG-3 in Regulatory T Cells

2004 • 1,198 citations

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression

2007 • 1,181 citations

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

2007 • 1,161 citations

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

2007 • 1,135 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

2004 • 1,123 citations

The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update

2010 • 1,086 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

2009 • 1,079 citations

Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

2004 • 972 citations

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

2009 • 963 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Broad Expression of Toll-Like Receptors in the Human Central Nervous System

2002 • 955 citations

Cell interactions in the induction of tolerance: the role of thymic lymphocytes.

1970 • 920 citations

Gastrointestinal dysfunction in Parkinson's disease

2003 • 892 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells

2001 • 888 citations

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

2007 • 871 citations

Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

2005 • 870 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

2007 • 836 citations

Type 1 T regulatory cells

2001 • 829 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

Infectious immunological tolerance.

1971 • 811 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

2007 • 804 citations

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

2011 • 790 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

Cutting Edge: CD4+CD25+ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis

2002 • 779 citations

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

2006 • 773 citations

How to infer gene networks from expression profiles

2007 • 771 citations

Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype

2007 • 730 citations

DNA methylation controls Foxp3 gene expression

2008 • 729 citations

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

2007 • 695 citations

TLR Signaling Tailors Innate Immune Responses in Human Microglia and Astrocytes

2005 • 676 citations

Pathway studio—the analysis and navigation of molecular networks

2003 • 675 citations

Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis

2005 • 666 citations

Foxp3⁺natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation

2008 • 663 citations

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

2007 • 661 citations

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

2009 • 644 citations

Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease

2006 • 617 citations

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

2007 • 599 citations

Interleukin-7 receptor expression: intelligent design

2007 • 597 citations

Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-Specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis

2001 • 589 citations

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

2005 • 589 citations

Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)

2000 • 580 citations

IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells

2007 • 579 citations

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

2003 • 574 citations

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

2004 • 572 citations

IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice

1998 • 558 citations

Clearance of Apoptotic Cells

2004 • 546 citations

Natural Recovery and Protection from Autoimmune Encephalomyelitis: Contribution of CD4+CD25+ Regulatory Cells within the Central Nervous System

2005 • 545 citations

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

2009 • 528 citations

Interleukin‐2 is essential for CD4⁺CD25⁺ regulatory T cell function

2004 • 521 citations

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10–dependent ILT4/HLA-G pathway

2010 • 513 citations

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

2005 • 508 citations

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

2008 • 503 citations

Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

2007 • 502 citations

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3⁺regulatory T cells

2008 • 501 citations

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

2008 • 501 citations

Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II

2008 • 494 citations

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells

2006 • 493 citations

CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells

2008 • 492 citations

The Limits of Reductionism in Medicine: Could Systems Biology Offer an Alternative?

2006 • 482 citations

Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers

2002 • 477 citations

A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease

2010 • 474 citations

Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells

2004 • 472 citations

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

2009 • 454 citations

CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ TH-17 cells in relapsing EAE

2007 • 452 citations

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

1998 • 447 citations

Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis

2005 • 439 citations

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS

2009 • 431 citations

Synuclein activates microglia in a model of Parkinson's disease

2007 • 431 citations

TGF-β regulatesin vivoexpansion of Foxp3-expressing CD4⁺CD25⁺regulatory T cells responsible for protection against diabetes

2004 • 425 citations

Blockade of CTLA-4 on CD4+CD25+ Regulatory T Cells Abrogates Their Function In Vivo

2006 • 422 citations

Brain Dendritic Cells and Macrophages/Microglia in Central Nervous System Inflammation

2001 • 410 citations

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like syndrome, and defective IL-10 expression from CD4 lymphocytes

2006 • 408 citations

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

2011 • 407 citations

Cutting Edge: TGF-β Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells

2004 • 395 citations

Bone Marrow-derived Elements in the Central Nervous System: An Immunohistochemical and Ultrastructural Survey of Rat Chimeras

1992 • 395 citations

Foxo Transcription Factors Control Regulatory T Cell Development and Function

2010 • 391 citations

Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson’s disease

2007 • 386 citations

Microglial senescence: does the brain's immune system have an expiration date?

2006 • 380 citations

The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age

2005 • 372 citations

Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

2010 • 372 citations

Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?

2005 • 370 citations

Decreased FOXP3 levels in multiple sclerosis patients

2005 • 367 citations

Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations

2004 • 358 citations

IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells

2004 • 354 citations

Epigenetic mechanisms of regulation of Foxp3 expression

2009 • 354 citations

Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration

2010 • 352 citations

Growth hormone, the insulin-like growth factor axis, insulin and cancer risk

2010 • 347 citations

Compromised CD4⁺ CD25^high regulatory T‐cell function in patients with relapsing‐remitting multiple sclerosis is correlated with a reduced frequency of FOXP3‐positive cells and reduced FOXP3 expression at the single‐cell level

2007 • 339 citations

Neuropilin-1 Expression on Regulatory T Cells Enhances Their Interactions with Dendritic Cells during Antigen Recognition

2008 • 333 citations

A Logical Model Provides Insights into T Cell Receptor Signaling

2007 • 332 citations

CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3⁺ regulatory T cells in gastric cancer

2008 • 332 citations

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

2009 • 324 citations

Microglia and Alzheimer's disease pathogenesis

2004 • 324 citations

Microglial cell population dynamics in the injured adult central nervous system

2005 • 319 citations

Expression of Inducible Nitric Oxide Synthase and Nitrotyrosine in Multiple Sclerosis Lesions

2001 • 318 citations

Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity

2009 • 312 citations

Developmental plasticity of CNS microglia

2001 • 309 citations

Activation requirements for the induction of CD4⁺CD25⁺ T cell suppressor function

2004 • 307 citations

Eos Mediates Foxp3-Dependent Gene Silencing in CD4 ⁺ Regulatory T Cells

2009 • 300 citations

Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop

2006 • 297 citations

CD40 Ligation Releases Immature Dendritic Cells from the Control of Regulatory CD4+CD25+ T Cells

2003 • 292 citations

Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis

2007 • 287 citations

The influence of microglia on the pathogenesis of Parkinson's disease

2009 • 283 citations

Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis

2006 • 277 citations

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

2011 • 266 citations

Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders

2004 • 263 citations

Regulatory functions of CD8+CD28– T cells in an autoimmune disease model

2003 • 262 citations

Treatment of the Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome (IPEX) by Allogeneic Bone Marrow Transplantation

2001 • 259 citations

A Disquisition on Suppressor T Cells

1975 • 255 citations

Neuroinflammation in Alzheimer's Disease and Parkinson's Disease: Are Microglia Pathogenic in Either Disorder?

2007 • 252 citations

Natural Naive CD4+CD25+CD127low Regulatory T Cell (Treg) Development and Function Are Disturbed in Multiple Sclerosis Patients: Recovery of Memory Treg Homeostasis during Disease Progression

2008 • 250 citations

Prevalence of Newly Generated Naive Regulatory T Cells (Treg) Is Critical for Treg Suppressive Function and Determines Treg Dysfunction in Multiple Sclerosis

2007 • 246 citations

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

2009 • 246 citations

CCR1+/CCR5+ Mononuclear Phagocytes Accumulate in the Central Nervous System of Patients with Multiple Sclerosis

2001 • 240 citations

Membrane protein GARP is a receptor for latent TGF‐β on the surface of activated human Treg

2009 • 236 citations

The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system

1996 • 235 citations

Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration

2007 • 235 citations

Review: Role of developmental inflammation and blood–brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases

2008 • 233 citations

Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease

2010 • 233 citations

Computational methods for discovering gene networks from expression data

2009 • 219 citations

Interleukin-10 (IL-10) Selectively Enhances CIS3/SOCS3 mRNA Expression in Human Neutrophils: Evidence for an IL-10–Induced Pathway That Is Independent of STAT Protein Activation

1999 • 212 citations

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

2010 • 208 citations

Gastrointestinal dysfunction in Parkinson's Disease

2009 • 206 citations

Inflammation in the early stages of neurodegenerative pathology

2011 • 204 citations

Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function

2007 • 201 citations

Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis

2005 • 197 citations

The role of the CD58 locus in multiple sclerosis

2009 • 195 citations

Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines

2002 • 194 citations

Altered miRNA expression in T regulatory cells in course of multiple sclerosis

2010 • 194 citations

Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients

2007 • 193 citations

Dramatic Shifts in Circulating CD4 but not CD8 T Cell Subsets in Mild Alzheimer's Disease

2009 • 186 citations

Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

2009 • 185 citations

Dopamine, through the Extracellular Signal-Regulated Kinase Pathway, Downregulates CD4⁺CD25⁺Regulatory T-Cell Activity: Implications for Neurodegeneration

2004 • 184 citations

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

2008 • 182 citations

Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Polypeptide Inhibit Tumor Necrosis Factor α Transcriptional Activation by Regulating Nuclear Factor-kB and cAMP Response Element-binding Protein/c-Jun

1998 • 177 citations

Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process

2009 • 176 citations

Innate Immunity in Multiple Sclerosis: Myeloid Dendritic Cells in Secondary Progressive Multiple Sclerosis Are Activated and Drive a Proinflammatory Immune Response

2006 • 175 citations

Alzheimer's disease, autoimmunity and inflammation. The good, the bad and the ugly

2011 • 166 citations

The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways

2010 • 160 citations

Dual effect of CD4⁺CD25⁺regulatory T cells in neurodegeneration: A dialogue with microglia

2004 • 159 citations

The Inflamed Central Nervous System Drives the Activation and Rapid Proliferation of Foxp3+ Regulatory T Cells

2007 • 159 citations

Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs

2008 • 158 citations

Microglia, Scavenger Receptors, and the Pathogenesis of Alzheimer’s Disease

1998 • 157 citations

CCR5 Δ32, matrix metalloproteinase-9 and disease activity in multiple sclerosis

2000 • 154 citations

Astrocyte elevated gene-1: Recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration

2007 • 153 citations

Identification of a Regulatory T Cell Specific Cell Surface Molecule that Mediates Suppressive Signals and Induces Foxp3 Expression

2008 • 152 citations

CD4+CD25+FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis

2006 • 151 citations

The roles for cytokines in the generation and maintenance of regulatory T cells

2006 • 147 citations

Influence of microbial environment on autoimmunity

2009 • 147 citations

Acceleration of Experimental Autoimmune Encephalomyelitis in Interleukin-10-Deficient Mice: Roles of Interleukin-10 in Disease Progression and Recovery

1998 • 145 citations

Characterization of Protective Human CD4+CD25+ FOXP3+ Regulatory T Cells Generated with IL-2, TGF-β and Retinoic Acid

2010 • 145 citations

Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase

2008 • 145 citations

Thymic Export Function and T Cell Homeostasis in Patients with Relapsing Remitting Multiple Sclerosis

2003 • 144 citations

Targeted Deletion of fgl2 Leads to Impaired Regulatory T Cell Activity and Development of Autoimmune Glomerulonephritis

2008 • 141 citations

Disturbed regulatory T cell homeostasis in multiple sclerosis

2010 • 140 citations

Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis

1997 • 137 citations

PD1 Negative and PD1 Positive CD4+ T Regulatory Cells in Mild Cognitive Impairment and Alzheimer's Disease

2010 • 134 citations

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit the production of inflammatory mediators by activated microglia

2003 • 133 citations

Loss of Tolerance and Autoimmunity Affecting Multiple Organs inSTAT5A/5B-Deficient Mice

2003 • 130 citations

TGF‐β‐induced Foxp3⁺ regulatory T cells rescue scurfy mice

2008 • 130 citations

Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion.

1998 • 129 citations

Rosiglitazone decreases peroxisome proliferator receptor-gamma levels in microglia and inhibits TNF-alpha production: new evidences on neuroprotection in a progressive Parkinson's disease model

2011 • 129 citations

Omics meet networks—using systems approaches to infer regulatory networks in plants

2009 • 128 citations

Vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide inhibit chemokine production in activated microglia

2002 • 127 citations

GARP: a key receptor controlling FOXP3 in human regulatory T cells

2009 • 121 citations

Oestrogen modulates experimental autoimmune encephalomyelitis and interleukin‐17 production via programmed death 1

2008 • 120 citations

Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population

2008 • 116 citations

Alterations of T cell subsets in ALS: a systemic immune activation?

2011 • 114 citations

Granulomas in schistosome and mycobacterial infections: a model of local immune responses

2002 • 113 citations

Glatiramer acetate improves regulatory T-cell function by expansion of naive CD4+CD25+FOXP3+CD31+ T-cells in patients with multiple sclerosis

2009 • 112 citations

The brain as an immune privileged site: dendritic cells of the central nervous system inhibit T cell activation

2003 • 111 citations

Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis

2010 • 110 citations

Expression of Amyotrophic Lateral Sclerosis-linked SOD1 Mutant Increases the Neurotoxic Potential of Microglia via TLR2

2008 • 110 citations

Superantigen-Induced Proliferation of Human CD4+CD25− T Cells Is Followed by a Switch to a Functional Regulatory Phenotype

2010 • 109 citations

Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor α-chain are excluded from the analysis

2008 • 105 citations

Intracerebral Human Regulatory T Cells: Analysis of CD4+CD25+FOXP3+ T Cells in Brain Lesions and Cerebrospinal Fluid of Multiple Sclerosis Patients

2011 • 103 citations

Microglia and prion disease

2001 • 101 citations

Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks

2007 • 99 citations

TGF-beta 2 decreases migration of lymphocytes in vitro and homing of cells into the central nervous system in vivo.

1995 • 99 citations

The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of action.

1999 • 97 citations

Degenerating Synaptic Boutons in Prion Disease

2009 • 97 citations

Glucocorticoids increase CD4⁺CD25^highcell percentage and Foxp3 expression in patients with multiple sclerosis

2008 • 97 citations

Characterizing emergent properties of immunological systems with multi-cellular rule-based computational modeling

2008 • 96 citations

Differential Cellular Accumulation of Connective Tissue Growth Factor Defines a Subset of Reactive Astrocytes, Invading Fibroblasts, and Endothelial Cells Following Central Nervous System Injury in Rats and Humans

2001 • 95 citations

A Potential Role for Estrogen in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

2006 • 94 citations

Loss of blood–brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models

2007 • 94 citations

Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis

2009 • 93 citations

Erythropoietin: A Potent Inducer of Peripheral Immuno/Inflammatory Modulation in Autoimmune EAE

2008 • 90 citations

VIP/PACAP oppositely affects immature and mature dendritic cell expression of CD80/CD86 and the stimulatory activity for CD4+ T cells

2004 • 88 citations

The β2-Adrenergic Agonist Salbutamol Is a Potent Suppressor of Established Collagen-Induced Arthritis: Mechanisms of Action

1999 • 85 citations

MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase‐6 regulates astrocyte survival

2010 • 84 citations

Sialoadhesin-Positive Macrophages Bind Regulatory T Cells, Negatively Controlling Their Expansion and Autoimmune Disease Progression

2009 • 83 citations

Vasoactive intestinal peptide induces regulatory T cells during experimental autoimmune encephalomyelitis

2006 • 82 citations

Neuromodulatory Activities of CD4+CD25+ Regulatory T Cells in a Murine Model of HIV-1-Associated Neurodegeneration

2009 • 82 citations

The sympathetic nervous system modulates CD4+FoxP3+ regulatory T cells via a TGF-β-dependent mechanism

2009 • 80 citations

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) associated with pemphigoid nodularis: A case report and review of the literature

2006 • 80 citations

Abnormal Tr1 differentiation in multiple sclerosis

2007 • 79 citations

Neonatal diabetes mellitus, enteropathy, thrombocytopenia, and endocrinopathy: Further evidence for an X-linked lethal syndrome

2001 • 79 citations

Neuropeptide Y Cotransmission with Norepinephrine in the Sympathetic Nerve—Macrophage Interplay

2000 • 78 citations

CD28 disruption exacerbates inflammation in Tgf-β1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-β1

2004 • 78 citations

Activated T cells complicate the identification of regulatory T cells in rheumatoid arthritis

2008 • 76 citations

The Chemokine Receptor CCR9 Is Required for the T-Cell–Mediated Regulation of Chronic Ileitis in Mice

2011 • 76 citations

Curating the innate immunity interactome

2010 • 75 citations

Microbiotal influence on T cell subset development

2011 • 75 citations

Microglial activation and neuroinflammation in Alzheimer's disease: a critical examination of recent history

2010 • 74 citations

Ex Vivo Generated Regulatory T Cells Modulate Experimental Autoimmune Myasthenia Gravis

2008 • 74 citations

The Intermediate Filament GFAP Is Important for the Control of Experimental MurineStaphylococcus aureus-Induced Brain Abscess andToxoplasmaEncephalitis

2004 • 72 citations

Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson’s disease? An analysis using the 13C-acetate breath test

2010 • 71 citations

VIP and PACAP Differentially Regulate the Costimulatory Activity of Resting and Activated Macrophages Through the Modulation of B7.1 and B7.2 Expression

1999 • 70 citations

Vaccination with autoantigen protects against aggregated β‐amyloid and glutamate toxicity by controlling microglia: effect of CD4⁺CD25⁺ T cells

2004 • 69 citations

Vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide promote in vivo generation of memory Th2 cells

2002 • 68 citations

Bone-marrow-derived cell differentiation into microglia: A study in a progressive mouse model of Parkinson's disease

2007 • 67 citations

CD25 regulatory T cells determine secondary but not primary remission in EAE: Impact on long-term disease progression

2005 • 66 citations

Targeting dendritic cells to treat multiple sclerosis

2010 • 66 citations

Comparison of stable human Treg and Th clones by transcriptional profiling

2009 • 65 citations

Regulatory T cells exhibit enhanced migratory characteristics, a feature impaired in patients with multiple sclerosis

2010 • 63 citations

Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis

2010 • 62 citations

Induction of CD4+CD25+FOXP3+ Regulatory T Cells during Human Hookworm Infection Modulates Antigen-Mediated Lymphocyte Proliferation

2011 • 61 citations

Numerical defects in CD8+CD28− T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis

2010 • 60 citations

Nerve-driven immunity: Neuropeptides regulate cytokine secretion of T cells and intestinal epithelial cells in a direct, powerful and contextual manner

2001 • 58 citations

Impairment of TGF-β signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice

2003 • 58 citations

C-Phycocyanin ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells

2010 • 57 citations

Circulating dendritic cells subsets and regulatory T-cells at multiple sclerosis relapse: Differential short-term changes on corticosteroids therapy

2006 • 57 citations

Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice

2011 • 55 citations

Effects of Natalizumab Treatment on Foxp3+ T Regulatory Cells

2008 • 55 citations

T Regulatory Cells in Cord Blood—FOXP3 Demethylation as Reliable Quantitative Marker

2010 • 54 citations

Elevated expression of CCR5 by myeloid (CD11c+) blood dendritic cells in multiple sclerosis and acute optic neuritis

2002 • 54 citations

Secretory phospholipase A2-IID is an effector molecule of CD4⁺CD25⁺regulatory T cells

2009 • 53 citations

CD2 Costimulation Reveals Defective Activity by Human CD4+CD25hi Regulatory Cells in Patients with Multiple Sclerosis

2011 • 52 citations

CD8+ suppressor T cells resurrected

2008 • 52 citations

CXCL12 enhances exogenous CD4+CD25+ T cell migration and prevents embryo loss in non-obese diabetic mice

2008 • 51 citations

Regulatory T cells in CNS injury: the simple, the complex and the confused

2011 • 51 citations

Haplotype 4 of the multiple sclerosis-associated interleukin-7 receptor alpha gene influences the frequency of recent thymic emigrants

2010 • 50 citations

Blood-derived dendritic cells in an acute brain injury

2005 • 49 citations

Myelin Basic Protein Priming Reduces the Expression of Foxp3 in T Cells via Nitric Oxide

2010 • 49 citations

Understanding apoptosis by systems biology approaches

2009 • 47 citations

CD8+Foxp3+ T cells in peripheral blood of relapsing-remitting multiple sclerosis patients

2010 • 47 citations

Gastric cancer cells induce human CD4⁺Foxp3⁺regulatory T cells through the production of TGF-β1

2011 • 45 citations

Substance P Regulates Somatostatin Expression in Inflammation

1998 • 44 citations

Growth hormone/insulin-like growth factor I axis in neurodegenerative diseases

2010 • 43 citations

The interleukin‐7 receptor α chain contributes to altered homeostasis of regulatory T cells in multiple sclerosis

2010 • 43 citations

Involvement of IFN-γ and perforin, but not Fas/FasL interactions in regulatory T cell-mediated suppression of experimental autoimmune encephalomyelitis

2010 • 40 citations

Receptors and effects of the inhibitory neuropeptide somatostatin in microglial cells

1998 • 39 citations

IL-21 receptor expression determines the temporal phases of experimental autoimmune encephalomyelitis

2007 • 39 citations

High-dose epinephrine acts at α2-adrenoceptors to suppress experimental arthritis

1991 • 37 citations

A cluster of coregulated genes determines TGF-β–induced regulatory T-cell (Treg) dysfunction in NOD mice

2011 • 36 citations

Human Regulatory T Cell Suppressive Function Is Independent of Apoptosis Induction in Activated Effector T Cells

2009 • 35 citations

Expression of brain-derived neurotrophic factor (BDNF) and inducible nitric oxide synthase (iNOS) in rat astrocyte cultures treated with Levetiracetam

2003 • 34 citations

Prospective immunological profiling in a case of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX)

2004 • 34 citations

VIP Prevents Experimental Multiple Sclerosis by Downregulating Both Inflammatory and Autoimmune Components of the Disease

2006 • 33 citations

Therapeutic T Cell-Based Vaccination for Neurodegenerative Disorders: The Role of CD4⁺CD25⁺Regulatory T Cells

2005 • 32 citations

Vasoactive Intestinal Peptide

2006 • 31 citations

Constitutive and Cytokine-Induced GITR Ligand Expression on Human Retinal Pigment Epithelium and Photoreceptors

2004 • 31 citations

Reverse engineering of metabolic networks, a critical assessment

2010 • 30 citations

Reduced Treg frequency in LFA‐1‐deficient mice allows enhanced T effector differentiation and pathology in EAE

2010 • 30 citations

Altered innate immune response of plasmacytoid dendritic cells in multiple sclerosis

2009 • 30 citations

The role of dendritic cells in multiple sclerosis

2007 • 28 citations

Repetitive Pertussis Toxin Promotes Development of Regulatory T Cells and Prevents Central Nervous System Autoimmune Disease

2010 • 28 citations

Bacterial Heat Shock Protein 60, GroEL, Can Induce the Conversion of Naïve T Cells into a CD4+ CD25+ Foxp3-Expressing Phenotype

2011 • 26 citations

Systems biology approaches to dissect mammalian innate immunity

2010 • 25 citations

Potassium channel expression in human CD4+ regulatory and naïve T cells from healthy subjects and multiple sclerosis patients

2009 • 25 citations

Microglia in amyotrophic lateral sclerosis.

2007 • 25 citations

Amyotrophic Lateral Sclerosis — Are Microglia Killing Motor Neurons?

2006 • 24 citations

Hormone therapy in rheumatic diseases

2010 • 23 citations

Monocyte-derived dendritic cells in multiple sclerosis: The effect of bacterial infection

2007 • 22 citations

The role of dendritic cells in neurodegenerative diseases.

2002 • 21 citations

Vasoactive Intestinal Peptide Generates CD4⁺CD25⁺ Regulatory T Cells in vivo

2006 • 21 citations

CD4+Foxp3+regulatory T cells induced by TGF-β, IL-2 and all-trans retinoic acid attenuate obliterative bronchiolitis in rat trachea transplantation

2011 • 19 citations

Congruent Effects of Estrogen and T-Cell Receptor Peptide Therapy on Regulatory T Cells in EAE and MS

2005 • 18 citations

CTLA-4 Engagement and Regulatory CD4+CD25+ T Cells Independently Control CD8+-Mediated Responses under Costimulation Blockade

2006 • 17 citations

Multiple sclerosis: reduced proportion of circulating plasmacytoid dendritic cells expressing BDCA-2 and BDCA-4 and reduced production of IL-6 and IL-10 in response to herpes simplex virus type 1

2008 • 17 citations

Decreased CD14+CCR2+ monocytes in active multiple sclerosis

2004 • 16 citations

FOXP3: Required but Not Sufficient. The Role of GARP (LRRC32) as a Safeguard of the Regulatory Phenotype

2010 • 15 citations

The Role of Microglial Cells in Amyotrophic Lateral Sclerosis

2005 • 9 citations

Changes in circulating dendritic cells and B-cells in patients with multiple sclerosis relapse during corticosteroid therapy

2009 • 9 citations

Sir,

2004 • 9 citations

FOXP3: Required but Not Sufficient. The Role of GARP (LRRC32) as a Safeguard of the Regulatory Phenotype

2010 • 7 citations

CD8+ suppressor cells resurrected and vindicated.

2011 • 2 citations

From the bench to the bedside: Gene therapy for Parkinson's disease, The roles of the habenula and nucleus accumbens in depression, Microglia and neurodegeneration.

2011 • 1 citations

Deleted Work

1955 • 0 citations