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Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process

Data up to Jan 2025

Published2009
Citations176
References48
Clinical Trials (1)

Total Citations Per Year

Abstract

References (48)

The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function

1999 • 2,843 citations

El escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis

1994 • 2,090 citations

Amyotrophic Lateral Sclerosis

2001 • 1,664 citations

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

2006 • 1,071 citations

Role of Axonal Transport in Neurodegenerative Diseases

2008 • 709 citations

Natural regulatory T cells: mechanisms of suppression

2007 • 704 citations

Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.

1992 • 531 citations

Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue

2003 • 519 citations

Amyotrophic Lateral Sclerosis-Associated SOD1 Mutant Proteins Bind and Aggregate with Bcl-2 in Spinal Cord Mitochondria

2004 • 490 citations

Inflammatory processes in amyotrophic lateral sclerosis

2002 • 460 citations

Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target

2006 • 452 citations

Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson’s disease

2007 • 386 citations

Clinical limits of amyotrophic lateral sclerosis.

1982 • 372 citations

Alterations of T-lymphocyte populations in Parkinson disease

2005 • 299 citations

Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis

1993 • 295 citations

The Pathobiology of Amyotrophic Lateral Sclerosis: A Proteinopathy?

2005 • 202 citations

Therapeutic vaccine for acute and chronic motor neuron diseases: Implications for amyotrophic lateral sclerosis

2003 • 201 citations

Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients

2007 • 193 citations

Circulating levels of tumour necrosis factor-α and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis

2000 • 192 citations

Altered expression of bcl‐2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons

1996 • 183 citations

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

2008 • 182 citations

The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS

2005 • 175 citations

Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice

2003 • 174 citations

Detection and cellular localization of enterovirus RNA sequences in spinal cord of patients with ALS

2000 • 174 citations

Excitotoxicity and Amyotrophic Lateral Sclerosis

2005 • 170 citations

Dual effect of CD4+CD25+regulatory T cells in neurodegeneration: A dialogue with microglia

2004 • 159 citations

Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)

2004 • 150 citations

Innate immunity in amyotrophic lateral sclerosis

2006 • 137 citations

Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis

1990 • 125 citations

Neuroinflammation and Peripheral Immune Infiltration in Parkinson's Disease: An Autoimmune Hypothesis

2008 • 117 citations

An ALS-like syndrome with new HIV infection and complete response to antiretroviral therapy

2001 • 113 citations

Production of monocyte chemoattractant protein‐1 in amyotrophic lateral sclerosis

2005 • 108 citations

Reversible ALS-like disorder in HIV infection

2018 • 105 citations

Activation of p38 Mitogen-Activated Protein Kinase In Vivo Selectively Induces Apoptosis of CD8+ but Not CD4+ T Cells

2000 • 98 citations

Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS

2005 • 97 citations

Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis.

1989 • 97 citations

Activated p38MAPK Is a Novel Component of the Intracellular Inclusions Found in Human Amyotrophic Lateral Sclerosis and Mutant SOD1 Transgenic Mice

2004 • 95 citations

In vitro induction of neuronal apoptosis by anti-Fas antibody-containing sera from amyotrophic lateral sclerosis patients

2000 • 78 citations

T cells in amyotrophic lateral sclerosis

2008 • 72 citations

Modified expression of Bcl-2 and SOD1 proteins in lymphocytes from sporadic ALS patients

2006 • 60 citations

MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS)

2006 • 58 citations

Immunity assessment in the early stages of amyotrophic lateral sclerosis: a study of virus antibodies and lymphocyte subsets

1988 • 49 citations

Increased intracellular calcium triggered by immune mechanisms in amyotrophic lateral sclerosis.

1995 • 47 citations

Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS

2006 • 42 citations

T Cell Receptor BV Gene Rearrangements in the Spinal Cords and Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis

1999 • 29 citations

Limited effects of glatiramer acetate in the high-copy number hSOD1-G93A mouse model of ALS

2007 • 23 citations

Cytoskeletal Defects in Amyotrophic Lateral Sclerosis (Motor Neuron Disease)

2005 • 18 citations

Disturbances in the Peripheral T‐Cell Repertoire of Patients with Motor Neuron Disease: High Levels of Activation and Indirect Evidence of Superantigen

2001 • 7 citations

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Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an… (2009) – Journal of Neuroimmunology | Metascience Observatory Explorer