Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

2003 • 582 citations

Oral tolerance

2005 • 573 citations

IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice

1998 • 558 citations

Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells

2004 • 519 citations

Oral tolerance.

1994 • 456 citations

Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis

2005 • 439 citations

Decreased FOXP3 levels in multiple sclerosis patients

2005 • 367 citations

Cutting Edge: Anti-CD25 Monoclonal Antibody Injection Results in the Functional Inactivation, Not Depletion, of CD4+CD25+ T Regulatory Cells

2006 • 333 citations

Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4⁺T cells via CD40 ligand

1997 • 313 citations

Design of effective immunotherapy for human autoimmunity

2005 • 276 citations

Tr1 cells: From discovery to their clinical application

2006 • 272 citations

Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis

1999 • 264 citations

Multiple sclerosis

2005 • 254 citations

How do CD4+CD25+ regulatory T cells control autoimmunity?

2005 • 249 citations

Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines

2004 • 239 citations

Regulatory T cells: Development, function and role in autoimmunity

2005 • 222 citations

Four Viruses, Two Bacteria, and One Receptor: Membrane Cofactor Protein (CD46) as Pathogens' Magnet

2004 • 210 citations

CD4+ regulatory T cells: Mechanisms of induction and effector function

2005 • 205 citations

Transgenic Interleukin 10 Prevents Induction of Experimental Autoimmune Encephalomyelitis

1999 • 203 citations

Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4CD25 T cells

2005 • 183 citations

Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell–induced inflammation

2002 • 176 citations

Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis.

1995 • 166 citations

Cutting Edge: CD46, a New Costimulatory Molecule for T Cells, That Induces p120CBL and LAT Phosphorylation

2000 • 158 citations

CD46/CD3 Costimulation Induces Morphological Changes of Human T Cells and Activation of Vav, Rac, and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase

2001 • 116 citations

Interferon beta induces T-helper 2 immune deviation in MS

1999 • 113 citations

Membrane Cofactor Protein (MCP; CD46): Isoform-Specific Tyrosine Phosphorylation

2000 • 101 citations

Polymorphic expression of CD46 protein isoforms due to tissue-specific RNA splicing

1993 • 98 citations

Initiation of autoimmunity

2004 • 81 citations

Multiple Sclerosis: Levels of Interleukin‐10‐Secreting Blood Mononuclear Cells are Low in Untreated Patients but Augmented During Interferon‐β‐1b Treatment

1999 • 71 citations

CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae

2002 • 71 citations

CD46: A complement regulator and pathogen receptor that mediates links between innate and acquired immune function

2004 • 68 citations

Single-cell analysis of cytokine production shows different immune profiles in multiple sclerosis patients with active or quiescent disease

2001 • 60 citations

A Functional Interaction between CD46 and DLG4

2002 • 60 citations

T-Cell Stimulation and Regulation: With Complements from CD46

2005 • 54 citations

Non‐Th2 Regulatory T‐Cell Control of Th1 Autoimmunity

2001 • 49 citations

Human CD46 Enhances Nitric Oxide Production in Mouse Macrophages in Response to Measles Virus Infection in the Presence of Gamma Interferon: Dependence on the CD46 Cytoplasmic Domains

1999 • 44 citations

CD46‐mediated costimulation induces a Th1‐biased response and enhances early TCR/CD3 signaling in human CD4⁺ T lymphocytes

2004 • 44 citations

Immunotherapeutic approaches in multiple sclerosis

2004 • 39 citations

TCR Peptide Vaccination in Multiple Sclerosis: Boosting a Deficient Natural Regulatory Network that may Involve TCR-Specific CD4+CD25+ Treg Cells

2005 • 37 citations

The cytoplasmic domains of complement regulatory protein CD46 interact with multiple kinases in macrophages

1997 • 36 citations

Applying a new generation of genetic maps to understand human inflammatory disease

2005 • 31 citations

Altered CD46-mediated T cell co-stimulation in haemodialysis patients

2005 • 21 citations

Activated suppressor cell function in severely disabled patients with multiple sclerosis

1989 • 19 citations

Functional characterisation of alternatively spliced CD46 cytoplasmic tails.

1992 • 13 citations

Ifn-β_1BTreatment of Relapsingmultiple Sclerosis Has no Effect on Cd3-Induced Inflammatory or Counterregulatory Anti-Inflammatory Cytokine Secretion Ex Vivo After Nine Months

1997 • 13 citations