Mitochondria in cardiomyocyte Ca2+ signaling

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

1995 • 5,025 citations

Cardiac excitation–contraction coupling

2002 • 4,343 citations

Mitochondrial Membrane Permeabilization in Cell Death

2007 • 3,375 citations

The mitochondrial permeability transition

1995 • 2,412 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

2008 • 2,181 citations

Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle

1993 • 1,917 citations

Excitation-Contraction Coupling and Cardiac Contractile Force

2010 • 1,661 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Excitation-Contraction Coupling and Cardiac Contractile Force

2001 • 1,509 citations

Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

2002 • 1,443 citations

The mitochondrial calcium uniporter is a highly selective ion channel

2004 • 1,348 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Molecular and cellular physiology of intracellular calcium stores

1994 • 1,132 citations

Mitochondrial ROS-induced ROS release: An update and review

2006 • 1,009 citations

Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.

1985 • 904 citations

Integrated Analysis of Protein Composition, Tissue Diversity, and Gene Regulation in Mouse Mitochondria

2003 • 873 citations

Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle

1977 • 817 citations

The internal structure of mitochondria

2000 • 810 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

Characterization of the human heart mitochondrial proteome

2003 • 706 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

Cardiac Ionic Currents and Acute Ischemia: From Channels to Arrhythmias

1999 • 692 citations

Superoxide Flashes in Single Mitochondria

2008 • 689 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 670 citations

Theory of excitation-contraction coupling in cardiac muscle

1992 • 651 citations

Role of Bax and Bak in mitochondrial morphogenesis

2006 • 608 citations

Shape, Size, and Distribution of Ca2+ Release Units and Couplons in Skeletal and Cardiac Muscles

1999 • 569 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

Mitochondria as all‐round players of the calcium game

2000 • 556 citations

THE ULTRASTRUCTURE OF THE CAT MYOCARDIUM

1969 • 553 citations

The control of calcium release in heart muscle

1995 • 547 citations

Calcium sparks and [Ca2+]i waves in cardiac myocytes

1996 • 524 citations

A Mathematical Treatment of Integrated Ca Dynamics within the Ventricular Myocyte

2004 • 523 citations

Calcium Sparks

2008 • 514 citations

ULTRASTRUCTURAL BASES FOR METABOLICALLY LINKED MECHANICAL ACTIVITY IN MITOCHONDRIA

1968 • 489 citations

VDAC: The channel at the interface between mitochondria and the cytosol

2003 • 470 citations

Cellular Basis of Abnormal Calcium Transients of Failing Human Ventricular Myocytes

2003 • 466 citations

Local calcium transients triggered by single L-type calcium channel currents in cardiac cells

1995 • 452 citations

Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.

1985 • 445 citations

Physiological Functions of Cyclic ADP-Ribose and NAADP as Calcium Messengers

2001 • 426 citations

Evolutionary conservation of biogenesis of β-barrel membrane proteins

2003 • 425 citations

Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes

1995 • 425 citations

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

2004 • 420 citations

Calcium Cycling in Congestive Heart Failure

2002 • 411 citations

RECENT ADVANCES IN STUDIES ON CARDIAC STRUCTURE AND METABOLISM

1973 • 401 citations

Regulation of the Cardiac Ryanodine Receptor Channel by Luminal Ca2+ Involves Luminal Ca2+ Sensing Sites

1998 • 393 citations

Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells

2001 • 393 citations

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice

2008 • 382 citations

Mitochondria: The Hub of Cellular Ca²⁺Signaling

2008 • 381 citations

An Integrated Model of Cardiac Mitochondrial Energy Metabolism and Calcium Dynamics

2003 • 380 citations

The Relationship between Free and Total Calcium Concentrations in the Matrix of Liver and Brain Mitochondria

2003 • 377 citations

Desmin Cytoskeleton Linked to Muscle Mitochondrial Distribution and Respiratory Function

2000 • 369 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

Spatial non-uniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes

1994 • 363 citations

Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function

2001 • 350 citations

Mitochondrial Depolarization Accompanies Cytochrome cRelease During Apoptosis in PC6 Cells

1999 • 347 citations

A Reevaluation of the Role of Mitochondria in Neuronal Ca²⁺ Homeostasis

1996 • 347 citations

Elevated Cytosolic Na ⁺ Decreases Mitochondrial Ca ²⁺ Uptake During Excitation-Contraction Coupling and Impairs Energetic Adaptation in Cardiac Myocytes

2006 • 344 citations

Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration

2008 • 333 citations

Cardiac Ca2+ Dynamics: The Roles of Ryanodine Receptor Adaptation and Sarcoplasmic Reticulum Load

1998 • 328 citations

The mitochondrial origin of postischemic arrhythmias

2005 • 326 citations

Remodeling of ryanodine receptor complex causes “leaky” channels: A molecular mechanism for decreased exercise capacity

2008 • 318 citations

The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

1999 • 316 citations

Mitochondria and Ca2+in cell physiology and pathophysiology

2000 • 312 citations

Role of Ca²⁺/calmodulin-dependent protein kinase (CaMK) in excitation–contraction coupling in the heart

2006 • 308 citations

Oxygen-bridged Dinuclear Ruthenium Amine Complex Specifically Inhibits Ca2+ Uptake into Mitochondria in Vitroand in Situ in Single Cardiac Myocytes

1998 • 306 citations

THE ULTRASTRUCTURE OF THE CAT MYOCARDIUM

1969 • 306 citations

Mitochondrial calcium transport

1980 • 304 citations

Integrative Analysis of Calcium Cycling in Cardiac Muscle

2000 • 302 citations

Intracellular Na+ regulation in cardiac myocytes

2003 • 301 citations

Mitochondrial Calcium Uptake from Physiological-type Pulses of Calcium

1995 • 299 citations

Mitochondrial Ion Channels

2006 • 298 citations

Termination of Cardiac Ca2+ Sparks: An Investigative Mathematical Model of Calcium-Induced Calcium Release

2002 • 297 citations

Quantitative Assessment of the SR Ca ²⁺ Leak-Load Relationship

2002 • 277 citations

Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes

1991 • 277 citations

Decreased Sarcoplasmic Reticulum Calcium Content Is Responsible for Defective Excitation-Contraction Coupling in Canine Heart Failure

2001 • 274 citations

Coupling membranes as energy-transmitting cables. I. Filamentous mitochondria in fibroblasts and mitochondrial clusters in cardiomyocytes.

1988 • 273 citations

Local Control Models of Cardiac Excitation–Contraction Coupling

1999 • 270 citations

Tubulin Is an Inherent Component of Mitochondrial Membranes That Interacts with the Voltage-dependent Anion Channel

2002 • 263 citations

Mitochondria Recycle Ca2+ to the Endoplasmic Reticulum and Prevent the Depletion of Neighboring Endoplasmic Reticulum Regions

2001 • 262 citations

Local control of excitation‐contraction coupling in rat heart cells.

1994 • 262 citations

RECENT ADVANCES IN STUDIES ON CARDIAC STRUCTURE AND METABOLISM

1976 • 261 citations

Mitochondrial Matrix Phosphoproteome: Effect of Extra Mitochondrial Calcium

2006 • 253 citations

Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore

1999 • 252 citations

Energetic Crosstalk Between Organelles

2001 • 245 citations

Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts

1999 • 243 citations

On the Role of VDAC in Apoptosis: Fact and Fiction

2005 • 242 citations

Identification of a Ryanodine Receptor in Rat Heart Mitochondria

2001 • 240 citations

Excitation-contraction coupling and mitochondrial energetics

2007 • 239 citations

Mitochondrial and sarcolemmal Ca2+ transport reduce [Ca2+]i during caffeine contractures in rabbit cardiac myocytes.

1992 • 235 citations

Relation Between the Sarcolemmal Ca ²⁺ Current and Ca ²⁺ Sparks and Local Control Theories for Cardiac Excitation-Contraction Coupling

1996 • 231 citations

Propagation of the apoptotic signal by mitochondrial waves

2001 • 231 citations

Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias

2006 • 227 citations

Mitochondrial membrane potential and hydroethidine‐monitored superoxide generation in cultured cerebellar granule cells

1997 • 224 citations

Calcium Signal Transmission between Ryanodine Receptors and Mitochondria

2000 • 218 citations

Beat-to-beat oscillations of mitochondrial [Ca2+] in cardiac cells

2001 • 216 citations

Calcium and the Heart

1971 • 214 citations

Preconditioning: The Mitochondrial Connection

2006 • 211 citations

Contribution of Abnormal Sarcoplasmic Reticulum ATPase Activity to Systolic and Diastolic Dysfunction in Human Heart Failure

1998 • 209 citations

VDAC regulation: role of cytosolic proteins and mitochondrial lipids

2008 • 208 citations

A Computational Model Integrating Electrophysiology, Contraction, and Mitochondrial Bioenergetics in the Ventricular Myocyte

2006 • 207 citations

Regulation of calcium release by calcium inside the sarcoplasmic reticulum in ventricular myocytes

1996 • 204 citations

An Integrative Model of the Cardiac Ventricular Myocyte Incorporating Local Control of Ca2+ Release

2002 • 203 citations

Distribution of the Na(+)-Ca2+ exchange protein in mammalian cardiac myocytes: an immunofluorescence and immunocolloidal gold-labeling study

1992 • 199 citations

Minimal model of beta-cell mitochondrial Ca2+ handling

1997 • 195 citations

Ca ²⁺ blinks: Rapid nanoscopic store calcium signaling

2005 • 193 citations

Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones.

1997 • 185 citations

Voltage-Independent Calcium Release in Heart Muscle

1990 • 183 citations

Selectivity of Inhibition of Na+-Ca2+ Exchange of Heart Mitochondria by Benzothiazepine CGP-37157

1993 • 182 citations

Transport of Ca2+ from sarcoplasmic reticulum to mitochondria in rat ventricular myocytes.

2000 • 179 citations

Ryanodine Receptors/Calcium Release channels in Heart Failure and Sudden Cardiac Death

2001 • 175 citations

Intracellular energetic units in red muscle cells

2001 • 170 citations

Local Ca2+ transients (Ca2+ sparks) originate at transverse tubules in rat heart cells.

1995 • 170 citations

Ca²⁺ sparks and Ca²⁺ waves in saponin‐permeabilized rat ventricular myocytes

1999 • 167 citations

The Absence of Desmin Leads to Cardiomyocyte Hypertrophy and Cardiac Dilation with Compromised Systolic Function

1999 • 167 citations

Model of β-cell mitochondrial calcium handling and electrical activity. II. Mitochondrial variables

1998 • 165 citations

Calcium Activation of Heart Mitochondrial Oxidative Phosphorylation

2001 • 164 citations

Functional implications of spontaneous sarcoplasmic reticulum Ca2+ release in the heart

1992 • 163 citations

Mitochondrial Electron Transport can Become a Significant Source of Oxidative Injury in Cardiomyocytes

1997 • 161 citations

Regulation of mitochondrial respiration in heart cells analyzed by reaction-diffusion model of energy transfer

2000 • 160 citations

Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes.

1997 • 159 citations

Sarcoplasmic Reticulum and Nuclear Envelope Are One Highly Interconnected Ca ²⁺ Store Throughout Cardiac Myocyte

2006 • 158 citations

The Integration of Mitochondrial Calcium Transport and Storage

2004 • 157 citations

Analysis of ryanodine receptor clusters in rat and human cardiac myocytes

2007 • 148 citations

Ca ²⁺ marks: Miniature calcium signals in single mitochondria driven by ryanodine receptors

2002 • 148 citations

Dynamic Regulation of Sarcoplasmic Reticulum Ca2+ Content and Release by Luminal Ca2+-Sensitive Leak in Rat Ventricular Myocytes

2001 • 147 citations

The rapid mode of calcium uptake into heart mitochondria (RaM): comparison to RaM in liver mitochondria

2001 • 146 citations

Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes

2007 • 144 citations

From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales

2008 • 143 citations

Thread-grain transition of mitochondrial reticulum as a step of mitoptosis and apoptosis

2003 • 142 citations

Physical Coupling Supports the Local Ca2+ Transfer between Sarcoplasmic Reticulum Subdomains and the Mitochondria in Heart Muscle

2008 • 142 citations

Mechanisms of Excitation-Contraction Coupling in an Integrative Model of the Cardiac Ventricular Myocyte

2005 • 141 citations

Chaperone-assisted pilus assembly and bacterial attachment

2000 • 140 citations

Mitochondrial Ca2+ and the heart

2008 • 140 citations

Mitochondrial Calcium Transients in Adult Rabbit Cardiac Myocytes: Inhibition by Ruthenium Red and Artifacts Caused by Lysosomal Loading of Ca2+-Indicating Fluorophores

2000 • 138 citations

Model of β-cell mitochondrial calcium handling and electrical activity. I. Cytoplasmic variables

1998 • 138 citations

Comparative Ultrastructure of Ca²⁺ Release Units in Skeletal and Cardiac Muscle

1998 • 133 citations

The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle.

1993 • 133 citations

Superinhibition of Sarcoplasmic Reticulum Function by Phospholamban Induces Cardiac Contractile Failure

2001 • 131 citations

Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells

1996 • 130 citations

Evidence for Ca ²⁺ Activation and Inactivation Sites on the Luminal Side of the Cardiac Ryanodine Receptor Complex

2000 • 130 citations

High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling

2008 • 130 citations

The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP‐ribose across membranes

1998 • 129 citations

Identification of the Enzymatic Active Site of CD38 by Site-directed Mutagenesis

2000 • 126 citations

The Fundamental Organization of Cardiac Mitochondria as a Network of Coupled Oscillators

2006 • 125 citations

ATP-sensitive potassium channel and bursting in the pancreatic beta cell. A theoretical study

1989 • 125 citations

Reverse Mode of the Sarcoplasmic Reticulum Calcium Pump and Load-Dependent Cytosolic Calcium Decline in Voltage-Clamped Cardiac Ventricular Myocytes

2000 • 123 citations

A Computational Model for Glycogenolysis in Skeletal Muscle

2002 • 123 citations

Mitochondrial morphology is dynamic and varied

2003 • 122 citations

Hamster cardiomyopathy. A defect in oxidative phosphorylation in the cardiac interfibrillar mitochondria.

1982 • 119 citations

Immunofluorescence localization of the Na-Ca exchanger in heart cells

1992 • 119 citations

The gating of the sheep skeletal sarcoplasmic reticulum Ca2+-release channel is regulated by luminal Ca2+

1995 • 112 citations

The role of luminal Ca²⁺ in the generation of Ca²⁺ waves in rat ventricular myocytes

1999 • 111 citations

Simultaneous Measurements of Mitochondrial NADH and Ca2+ during Increased Work in Intact Rat Heart Trabeculae

2002 • 110 citations

Evolution of Cardiac Calcium Waves from Stochastic Calcium Sparks

2001 • 110 citations

Na ⁺ -Ca ²⁺ Exchange Activity Is Localized in the T-Tubules of Rat Ventricular Myocytes

2002 • 109 citations

Local Ca2+ Signaling and EC Coupling in Heart: Ca2+ Sparks and the Regulation of the [Ca2+]i Transient

2002 • 106 citations

Quantification of calcium signal transmission from sarco‐endoplasmic reticulum to the mitochondria

2000 • 106 citations

Ultrastructure of crista supraventricularis muscle in patients with congenital heart diseases associated with right ventricular outflow tract obstruction.

1975 • 103 citations

Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na+-Ca2+ exchange

1993 • 102 citations

Intracellular calcium and ventricular fibrillation. Studies in the aequorin-loaded isovolumic ferret heart.

1991 • 101 citations

The effects of tension on acetylstrophanthidin-induced transient depolarizations and aftercontractions in canine myocardial and Purkinje tissues.

1976 • 100 citations

Effect of changes in action potential spike configuration, junctional sarcoplasmic reticulum micro-architecture and altered t-tubule structure in human heart failure

2006 • 98 citations

Analysis of cardiac mitochondrial Na⁺–Ca²⁺ exchanger kinetics with a biophysical model of mitochondrial Ca²⁺ handing suggests a 3: 1 stoichiometry

2008 • 96 citations

Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure

1999 • 96 citations

Measurement of Free Ca2+ in Sarcoplasmic Reticulum in Perfused Rabbit Heart Loaded with 1,2-Bis(2-amino-5,6-difluorophenoxy)ethane-N,N,N′,N′-tetraacetic Acid by 19F NMR

1996 • 96 citations

Probing the Outer Mitochondrial Membrane in Cardiac Mitochondria with Nanoparticles

2006 • 95 citations

Two Kinds of Calcium-Induced Release of Calcium from the Sarcoplasmic Reticulum of Skinned Cardiac Cells

1992 • 95 citations

Role of the Mitochondrial Permeability Transition in Salicylate Toxicity to Cultured Rat Hepatocytes: Implications for the Pathogenesis of Reye's Syndrome

1997 • 95 citations

Intracellular calcium mobilization by inositol 1,4,5-trisphosphate: intracellular movements and compartmentalization

1993 • 95 citations

Changes in mitochondrial calcium concentration during the cardiac contraction cycle

1993 • 94 citations

Effect of Na⁺/Ca²⁺ exchange inhibitor, KB‐R7943 on ouabain‐induced arrhythmias in guinea‐pigs

1999 • 94 citations

Mitochondria respond to Ca2+ already in the submicromolar range: correlation with redox state

2002 • 93 citations

Theoretical studies on the control of oxidative phosphorylation in muscle mitochondria: application to mitochondrial deficiencies

1996 • 91 citations

Cardiac Energy Metabolism: Models of Cellular Respiration

2001 • 90 citations

Dynamics of Nucleotides in VDAC Channels: Structure-Specific Noise Generation

2002 • 90 citations

Caveolin-3 Is Adjacent to a Group of Extradyadic Ryanodine Receptors

2005 • 87 citations

Functional coupling as a basic mechanism of feedback regulation of cardiac energy metabolism

2003 • 86 citations

Regulation of oxidative phosphorylation through parallel activation

2007 • 86 citations

Calcineurin regulates ryanodine receptor/Ca2+-release channels in rat heart

2000 • 85 citations

Termination of Ca²⁺ release during Ca²⁺ sparks in rat ventricular myocytes

1998 • 85 citations

Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinase

2008 • 84 citations

Microtubules and desmin filaments during onset of heart hypertrophy in rat: a double immunoelectron microscope study.

1987 • 83 citations

Role of Mitochondria in Calcium Regulation of Spontaneously Contracting Cardiac Muscle Cells

1998 • 81 citations

tcBid promotes Ca2+ signal propagation to the mitochondria: control of Ca2+ permeation through the outer mitochondrial membrane

2002 • 81 citations

Synergistic Movements of Ca2+ and Bax in Cells Undergoing Apoptosis

2001 • 80 citations

Mitochondrial membrane potential modulates regulation of mitochondrial Ca²⁺in rat ventricular myocytes

2004 • 79 citations

Mitochondrial redox state and Ca²⁺ sparks in permeabilized mammalian skeletal muscle

2005 • 78 citations

Potentiation of Ca ²⁺ Release by cADP-Ribose in the Heart Is Mediated by Enhanced SR Ca ²⁺ Uptake Into the Sarcoplasmic Reticulum

2001 • 77 citations

Calcium uptake by two preparations of mitochondria from heart

1980 • 74 citations

Oscillations of the glycolytic pathway and the purine nucleotide cycle

1979 • 74 citations

Analysis of Functional Coupling: Mitochondrial Creatine Kinase and Adenine Nucleotide Translocase

2004 • 74 citations

Inhibition of Ca2+ Sparks by Ruthenium Red in Permeabilized Rat Ventricular Myocytes

2000 • 73 citations

CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons

1997 • 73 citations

Ca2+ cycling between sarcoplasmic reticulum and mitochondria in rabbit cardiac myocytes.

1993 • 72 citations

Simulation of ATP metabolism in cardiac excitation–contraction coupling

2004 • 72 citations

Mitochondrial calcium signaling driven by the IP3 receptor.

2000 • 71 citations

Calcium Cycling in Heart Failure: The Arrhythmia Connection

2002 • 69 citations

Effect of nicotinic acid adenine dinucleotide phosphate on ryanodine calcium release channel in heart

2000 • 68 citations

ADP-Ribosyl Cyclase and CD38

1997 • 68 citations

The mitochondrial ryanodine receptor in rat heart: A pharmaco-kinetic profile

2007 • 67 citations

VDAC Channels Differentiate between Natural Metabolites and Synthetic Molecules

2002 • 67 citations

Mitochondrial Swelling Measurement In Situ by Optimized Spatial Filtering: Astrocyte-Neuron Differences

2008 • 66 citations

Enzymatic-Synthesis and Degradation of Nicotinate Adenine Dinucleotide Phosphate (NAADP), a Ca2+-Releasing Agonist, in Rat Tissues

1995 • 65 citations

Effect of Ca²⁺ on cardiac mitochondrial energy production is modulated by Na⁺ and H⁺ dynamics

2007 • 65 citations

Cyclic ADP-ribose

2000 • 64 citations

Integration of rapid cytosolic Ca²⁺ signals by mitochondria in cat ventricular myocytes

2006 • 64 citations

Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore

1999 • 62 citations

Multiple mechanisms of transmitter release evoked by ‘pathologically’ elevated extracellular [K⁺]: involvement of transporter reversal and mitochondrial calcium

2002 • 61 citations

Localization of Ca2+ + Mg2+-ATPase of the sarcoplasmic reticulum in adult rat papillary muscle.

1982 • 60 citations

Structural Proximity of Mitochondria to Calcium Release Units in Rat Ventricular Myocardium May Suggest a Role in Ca²⁺ Sequestration

1998 • 60 citations

Pyruvate augments calcium transients and cell shortening in rat ventricular myocytes

1998 • 59 citations

Regulation of the Ca ²⁺ Gradient Across the Sarcoplasmic Reticulum in Perfused Rabbit Heart

1998 • 58 citations

Identification of bovine liver mitochondrial NAD+ glycohydrolase as ADP-ribosyl cyclase

1997 • 56 citations

NMDA-Induced Calcium Loads Recycle Across the Mitochondrial Inner Membrane of Hippocampal Neurons in Culture

2002 • 56 citations

Mitochondrial Ca2+ transients in cardiac myocytes during the excitation-contraction cycle: effects of pacing and hormonal stimulation.

1998 • 55 citations

Synthesis of NAADP and cADPR in Mitochondria

1999 • 55 citations

Bacterial adhesins: structural studies reveal chaperone function and pilus biogenesis

2000 • 54 citations

Metabolic Regulation of Ca²⁺ Release in Permeabilized Mammalian Skeletal Muscle Fibres

2003 • 54 citations

Mitochondrial Calcium Signaling and Energy Metabolism

2005 • 52 citations

Three dimensional arrangement of mitochondria and endoplasmic reticulum in the heart muscle fiber of the rat

1981 • 52 citations

ELECTRON MICROSCOPIC DEMONSTRATION OF ADENOSINETRIPHOSPHATASE IN MYOFIBRILS AND SARCOPLASMIC MEMBRANES OF CARDIAC MUSCLE OF NORMAL AND ABNORMAL DOGS.

1964 • 51 citations

Mitochondrial Ca²⁺-activated K⁺channels more efficiently reduce mitochondrial Ca²⁺overload in rat ventricular myocytes

2007 • 50 citations

Mitochondria regulate inactivation of L‐type Ca²⁺ channels in rat heart

2001 • 50 citations

Immunoelectron microscopical localization of phospholamban in adult canine ventricular muscle.

1987 • 48 citations

Sarcoplasmic reticulum Ca release in intact ventricular myocytes

2002 • 48 citations

Simulation of cardiac work transitions, in vitro: effects of simultaneous Ca2+and ATPase additions on isolated porcine heart mitochondria

2001 • 47 citations

Measurement of Instantaneous Velocity Vectors of Organelle Transport: Mitochondrial Transport and Bioenergetics in Hippocampal Neurons

2008 • 47 citations

Regulation of the mitochondrial outer membrane channel, VDAC

1987 • 47 citations

Aqueous Diffusion Pathways as a Part of the Ventricular Cell Ultrastructure

2005 • 47 citations

Analysing cardiac excitation–contraction coupling with mathematical models of local control

2004 • 45 citations

Functional groups of ryanodine receptors in rat ventricular cells

2007 • 44 citations

Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle

1992 • 44 citations

Twitch‐potentiation increases calcium in peripheral more than in central mitochondria of guinea‐pig ventricular myocytes

1999 • 43 citations

Modeling mitochondrial function

2006 • 41 citations

Intracellular Sodium Modulates Mitochondrial Calcium Signaling in Vascular Endothelial Cells

2000 • 41 citations

Nicotinic acid‒adenine dinucleotide phosphate (NAADP) elicits specific microsomal Ca2+ release from mammalian cells

2001 • 39 citations

Immunogold-labeled L-type Calcium Channels are Clustered in the Surface Plasma Membrane Overlying Junctional Sarcoplasmic Reticulum in Guinea-pig Myocytes—Implications for Excitation–contraction Coupling in Cardiac Muscle

2000 • 39 citations

Phosphate Increases Mitochondrial Reactive Oxygen Species Release

2004 • 38 citations

Net calcium exchange in adult rat ventricular myocytes: an assessment of mitochondrial calcium accumulating capacity

1984 • 38 citations

On the existence of two populations of mitochondria in a single organ. Respiration, calcium transport and enzyme activities

1978 • 38 citations

Ca2+-Handling Proteins and Heart Failure: Novel Molecular Targets?

2003 • 38 citations

Single-Channel Currents of the Permeability Transition Pore from the Inner Mitochondrial Membrane of Rat Liver and of a Human Hepatoma Cell Line

2002 • 38 citations

Mitochondria regulate Ca²⁺ wave initiation and inositol trisphosphate signal transduction in oligodendrocyte progenitors

2002 • 37 citations

Effects of cytosolic ATP on spontaneous and triggered Ca²⁺‐induced Ca²⁺ release in permeabilised rat ventricular myocytes

2000 • 37 citations

Cyclosporin A treatment alters characteristics of Ca²⁺-release channel in cardiac sarcoplasmic reticulum

1999 • 36 citations

The role of the sarcoplasmic reticulum in various types of cardiomyocytes

1994 • 36 citations

Flufenamic acid as an inducer of mitochondrial permeability transition.

2000 • 35 citations

NADH: Ubiquinone Oxidoreductase Inhibitors Block Induction of Ornithine Decarboxylase Activity in MCF‐7 Human Breast Cancer Cells*

1998 • 34 citations

Sarcoplasmic Reticulum-Associated and Protein Kinase C-Regulated ADP-Ribosyl Cyclase in Cardiac Muscle

1997 • 34 citations

Control of mitochondrial matrix calcium: Studies using fluo-3 as a fluorescent calcium indicator

1990 • 33 citations

Effects of Cytosolic ATP on Ca ²⁺ Sparks and SR Ca ²⁺ Content in Permeabilized Cardiac Myocytes

2001 • 29 citations

Three‐dimensional electron microscopy of mitochondria and endoplasmic reticulum in the red muscle fiber of the rat diaphragm

1980 • 28 citations

Characteristics of Prolonged Ca ²⁺ Release Events Associated With the Nuclei in Adult Cardiac Myocytes

2004 • 28 citations

Subpopulations of human heart mitochondria

1986 • 26 citations

Physiological and Pathological Significance of the CD38-cyclic ADP-Ribose Signaling System

2000 • 26 citations

Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition

2002 • 25 citations

Altered Ca2+ homeostasis and impaired mitochondrial function in cardiomyopathy.

2002 • 25 citations

Depletion of Ca ²⁺ from the sarcoplasmic reticulum of cardiac muscle prompts phosphorylation of phospholamban to stimulate store refilling

1998 • 23 citations

Electrophysiology, Arrhythmias

2002 • 23 citations

Calcineurin regulates ryanodine receptor/Ca2+-release channels in rat heart

2000 • 22 citations

The role of Na dysregulation in cardiac disease and how it impacts electrophysiology

2007 • 22 citations

Rapid preparation of subsarcolemmal and interfibrillar mitochondrial subpopulations from cardiac muscle

1993 • 21 citations

An Ultrastructural Study of Cardiac Myocytes in Postmyocardial Infarction Ventricular Aneurysm Representative of Chronic Ischemic Myocardium Using Semiquantitative and Quantitative Assessment

2000 • 21 citations

The effects of sodium, hydrogen and magnesium ions on mitochondrial calcium sequestration in adult rat ventricular myocytes

1984 • 21 citations

Intracellular Calcium Modulators for Cardiac Muscle in Pathological Conditions.

1996 • 20 citations

Changes in Calcium Uptake Rate by Rat Cardiac Mitochondria during Postnatal Development

1998 • 20 citations

Colocalization of BAX with BID and VDAC-1 in nimesulide-induced apoptosis of human colon adenocarcinoma COLO 205 cells

2002 • 18 citations

A novel technique for quantitative measurement of free Ca²⁺ concentration in rat heart mitochondria

1999 • 16 citations

The Luminal Ca2+ Transient Controls Ca2+ Release/ Re-uptake of Sarcoplasmic Reticulum

2000 • 16 citations

Uncoupler-stimulated release of Ca2+ from Ehrlich ascites tumor cell mitochondria

1985 • 14 citations

Sarcoplasmic reticulum Ca release in intact ventricular myocytes

2002 • 14 citations

On the mechanism of the failure of mitochondrial function in isolated guinea-pig myocytes subjected to a Ca2+ overload

1999 • 14 citations

Experimental Myocardial Ischemia

1985 • 10 citations

Delivery of nano-objects to functional sub-domains of healthy and failing cardiac myocytes

2007 • 9 citations

Inhibition of the mitochondrial respiratory chain in isolated atria—A comparision of rotenone and amytal

1970 • 8 citations

Calcium content of peripheral and central mitochondria in the guinea pig myocardium: electron probe analysis

2003 • 7 citations

Electron microscopic studies on ATPase activities in myocardial infarction.

1976 • 4 citations

[Quantitative analysis of the mitochondrial ultrastructure of cardiomyocytes in rats adapting to altitude hypoxia].

1982 • 2 citations

Quantitative analysis of cardiomyocyte mitochondrial ultrastructure of rats adapted to altitude hypoxia

1982 • 1 citations