Physiological Functions of Cyclic ADP-Ribose and NAADP as Calcium Messengers

MOLMOL: A program for display and analysis of macromolecular structures

1996 • 7,169 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle

1993 • 1,917 citations

Defense gene induction in tobacco by nitric oxide, cyclic GMP, and cyclic ADP-ribose

1998 • 1,330 citations

Ryanodine Receptor/Ca2+ Release Channels and Their Regulation by Endogenous Effectors

1994 • 908 citations

Formation and Hydrolysis of Cyclic ADP-Ribose Catalyzed by Lymphocyte Antigen CD38

1993 • 735 citations

Ca ²⁺ -Induced Ca ²⁺ Release in Sea Urchin Egg Homogenates: Modulation by Cyclic ADP-Ribose

1991 • 628 citations

Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.

1987 • 569 citations

Structural Determination of a Cyclic Metabolite of NAD+ with Intracellular Ca2+-mobilizing Activity

1989 • 485 citations

A Derivative of NADP Mobilizes Calcium Stores Insensitive to Inositol Trisphosphate and Cyclic ADP-ribose

1995 • 479 citations

Cyclic ADP-Ribose in Insulin Secretion from Pancreatic βCells

1993 • 447 citations

Abscisic Acid Signaling Through Cyclic ADP-Ribose in Plants

1997 • 420 citations

ADP-ribosyl Cyclase and CD38 Catalyze the Synthesis of a Calcium-mobilizing Metabolite from NADP+

1995 • 408 citations

Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells

1999 • 387 citations

Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP

1997 • 366 citations

Cyclic ADP-ribose as an endogenous regulator of the non-skeletal type ryanodine receptor Ca2+ channel

1993 • 365 citations

ATP-dependent accumulation and inositol trisphosphate- or cyclic ADP-ribose-mediated release of Ca2+ from the nuclear envelope

1995 • 364 citations

Abscisic acid induces oscillations in guard-cell cytosolic free calcium that involve phosphoinositide-specific phospholipase C

1999 • 356 citations

ADP-ribosyl cyclase: an enzyme that cyclizes NAD+ into a calcium-mobilizing metabolite.

1991 • 354 citations

Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation.

1990 • 344 citations

Release of Ca ²⁺ from Individual Plant Vacuoles by Both InsP ₃ and Cyclic ADP-Ribose

1995 • 343 citations

cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis

1993 • 337 citations

Redundant Mechanisms of Calcium-Induced Calcium Release Underlying Calcium Waves During Fertilization of Sea Urchin Eggs

1993 • 313 citations

Abscisic acid-induced stomatal closure mediated by cyclic ADP-ribose

1998 • 312 citations

Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose

1999 • 308 citations

Calmodulin activation and inhibition of skeletal muscle Ca2+ release channel (ryanodine receptor)

1995 • 299 citations

Calcium Mobilization by Dual Receptors During Fertilization of Sea Urchin Eggs

1993 • 296 citations

Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.

1993 • 275 citations

Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose.

1993 • 259 citations

Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca2+ release

1993 • 259 citations

Synthesis and Degradation of Cyclic ADP-Ribose by NAD Glycohydrolases

1993 • 246 citations

Inositol Trisphosphate and Cyclic ADP-Ribose–Mediated Release of Ca2+ from Single Isolated Pancreatic Zymogen Granules

1996 • 238 citations

Cyclic ADP ribose activation of the ryanodine receptor is mediated by calmodulin

1994 • 230 citations

Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38

1992 • 228 citations

Cyclic ADP-ribose regulation of ryanodine receptors involved in agonist evoked cytosolic Ca2+ oscillations in pancreatic acinar cells.

1994 • 211 citations

CD38 Disruption Impairs Glucose-induced Increases in Cyclic ADP-ribose, [Ca2+] , and Insulin Secretion

1999 • 210 citations

Cyclic ADP-ribose Binds to FK506-binding Protein 12.6 to Release Ca2+ from Islet Microsomes

1997 • 200 citations

Crystal Structure of Diphtheria Toxin Bound to Nicotinamide Adenine Dinucleotide

1996 • 200 citations

An evaluation of the nitric oxide/cGMP/cGMP-dependent protein kinase cascade in the induction of cerebellar long-term depression in culture

1995 • 193 citations

Widespread occurrence in animal tissues of an enzyme catalyzing the conversion of NAD+ into a cyclic metabolite with intracellular Ca2+-mobilizing activity

1989 • 191 citations

Comparison of Ca2+ mobilizing activities of cyclic ADP-ribose and inositol trisphosphate.

1990 • 188 citations

Polarized Expression of Ca2+ Pumps in Pancreatic and Salivary Gland Cells

1997 • 184 citations

Activation and Inactivation of Ca Release by NAADP

1996 • 183 citations

Nicotinic acid-adenine dinucleotide phosphate mobilizes Ca2+ from a thapsigargin-insensitive pool

1996 • 177 citations

Ca²⁺ sparks and Ca²⁺ waves in saponin‐permeabilized rat ventricular myocytes

1999 • 167 citations

Two functionally distinct cholecystokinin receptors show different modes of action on Ca2+ mobilization and phospholipid hydrolysis in isolated rat pancreatic acini. Studies using a new cholecystokinin analog, JMV-180.

1990 • 166 citations

Unique Inactivation Properties of NAADP-sensitive Ca2+ Release

1996 • 163 citations

Functional Characterization of the Recombinant Type 3 Ca2+ Release Channel (Ryanodine Receptor) Expressed in HEK293 Cells

1997 • 162 citations

A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis

1999 • 161 citations

Agonist-stimulated Cyclic ADP Ribose

1995 • 152 citations

Cyclic ADP-ribose modulates Ca2+ release channels for activation by physiological Ca2+ entry in bullfrog sympathetic neurons

1994 • 149 citations

Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38

1996 • 148 citations

Sensitization of Calcium-induced Calcium Release by Cyclic ADP-ribose and Calmodulin

1995 • 144 citations

Role of cyclic ADP-ribose in the regulation of [Ca²⁺]_iin porcine tracheal smooth muscle

1998 • 139 citations

Ryanodine Receptor-Ankyrin Interaction Regulates Internal Ca2+ Release in Mouse T-lymphoma Cells

1995 • 137 citations

Activation of Ca(2+)-dependent currents in cultured rat dorsal root ganglion neurones by a sperm factor and cyclic ADP-ribose.

1992 • 130 citations

Cyclic ADP-ribose and Inositol 1,4,5-Trisphosphate as Alternate Second Messengers for Intracellular Ca2+ Mobilization in Normal and Diabetic β-Cells

1998 • 130 citations

The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP‐ribose across membranes

1998 • 129 citations

Wide distribution of an enzyme that catalyzes the hydrolysis of cyclic ADP-ribose

1993 • 127 citations

Identification of the Enzymatic Active Site of CD38 by Site-directed Mutagenesis

2000 • 126 citations

Expression of CD38 Increases Intracellular Calcium Concentration and Reduces Doubling Time in HeLa and 3T3 Cells

1998 • 122 citations

Calcium Signaling by Cyclic ADP-ribose, NAADP, and Inositol Trisphosphate Are Involved in Distinct Functions in Ascidian Oocytes

1998 • 121 citations

Cyclic ADP-Ribose: Metabolism and Calcium Mobilizing Function

1994 • 120 citations

The Type 2 Ryanodine Receptor of Neurosecretory PC12 Cells Is Activated by Cyclic ADP-ribose

1996 • 119 citations

Functional properties of the ryanodine receptor type3 (RyR3) Ca2+ release channel

1998 • 119 citations

Determination of endogenous levels of cyclic ADP-ribose in rat tissues

1991 • 119 citations

Anti-Ig-induced Calcium Influx in Rat B Lymphocytes Mediated by cGMP through a Dihydropyridine-sensitive Channel

1996 • 118 citations

Identification of cyclic ADP-ribose-binding proteins by photoaffinity labeling.

1993 • 116 citations

Regulatory Role of CD38 (ADP-ribosyl Cyclase/Cyclic ADP-ribose Hydrolase) in Insulin Secretion by Glucose in Pancreatic βCells

1995 • 115 citations

Cyclic ADP‐ribose‐induced Ca²⁺ release from rat brain microsomes

1993 • 114 citations

Enzymatic Functions and Structures of CD38 and Homologs

2000 • 114 citations

Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs

1995 • 114 citations

The Reaction Mechanism for CD38. A Single Intermediate Is Responsible for Cyclization, Hydrolysis, and Base-Exchange Chemistries

1998 • 113 citations

The existence of inositol 1,4,5-trisphosphate and ryanodine receptors in mature bovine oocytes

1995 • 111 citations

Nicotinic Acid Adenine Dinucleotide Phosphate-induced Ca2+ Release

2000 • 111 citations

Production and Hydrolysis of Cyclic ADP-Ribose at the Outer Surface of Human Erythrocytes

1993 • 111 citations

Induction of Hippocampal LTD Requires Nitric-Oxide-Stimulated PKG Activity and Ca²⁺Release From Cyclic ADP-Ribose-Sensitive Stores

1999 • 109 citations

Cyclic ADP-ribose competes with ATP for the adenine nucleotide binding site on the cardiac ryanodine receptor Ca(2+)-release channel.

1994 • 107 citations

Ligand‐induced internalization of CD38 results in intracellular Ca²⁺mobilization: role of NAD⁺transport across cell membranes

1999 • 107 citations

Pharmacological properties of the Ca²⁺‐release mechanism sensitive to NAADP in the sea urchin egg

1997 • 107 citations

Characterization of the Catalytic Site of the ADP-Ribosyltransferase Clostridium botulinum C2 Toxin by Site-directed Mutagenesis

1998 • 106 citations

Requirement of Calmodulindependent Protein Kinase II in Cyclic ADP-ribose-mediated Intracellular Ca2+ Mobilization

1995 • 105 citations

Muscarinic Receptor-mediated Dual Regulation of ADP-ribosyl Cyclase in NG108-15 Neuronal Cell Membranes

1997 • 103 citations

Molecular Cloning of Murine BST-1 Having Homology with CD38 and Aplysia ADP-Ribosyl Cyclase

1994 • 102 citations

Cyclic GMP-dependent and -independent Effects on the Synthesis of the Calcium Messengers Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate

1998 • 102 citations

A specific cyclic ADP-ribose antagonist inhibits cardiac excitation–contraction coupling

1996 • 100 citations

Nicotinic acid adenine dinucleotide phosphate triggers Ca2+ release from brain microsomes

1999 • 99 citations

Evidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampus

1999 • 99 citations

Cyclic ADP‐ribose and calcium‐induced calcium release regulate neurotransmitter release at a cholinergic synapse of Aplysia

1998 • 98 citations

Neuronal localization of CD38 antigen in the human brain

1995 • 95 citations

Ca2+ Entry Induced by Cyclic ADP-ribose in Intact T-Lymphocytes

1997 • 94 citations

Effects of 1-methyladenine on nuclear Ca2* transients and meiosis resumption in starfish oocytes are mimicked by the nuclear injection of inositol 1,4,5-trisphosphate and cADP-ribose

1997 • 94 citations

Stimulation of Cyclic ADP-ribose Synthesis by Acetylcholine and Its Role in Catecholamine Release in Bovine Adrenal Chromaffin Cells

1997 • 94 citations

Cyclic ADP-ribose

1999 • 90 citations

Developmental Changes in the Intracellular Ca 2+ Release Mechanisms in Porcine Oocytes1

1997 • 89 citations

Specific binding of cyclic ADP-ribose to calcium-storing microsomes from sea urchin eggs

1991 • 89 citations

Sympathetic Potentiation of Cyclic ADP-ribose Formation in Rat Cardiac Myocytes

1999 • 88 citations

Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin- dependent diabetes patients.

1998 • 88 citations

Nicotinamide inhibits cyclic ADP-ribose-mediated calcium signalling in sea urchin eggs

1996 • 87 citations

Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+ release in T lymphocyte cell lines.

1995 • 85 citations

7-Deaza-8-bromo-cyclic ADP-ribose, the First Membrane-permeant, Hydrolysis-resistant Cyclic ADP-ribose Antagonist

1997 • 85 citations

Localization of the Cyclic ADP-ribose-dependent Calcium Signaling Pathway in Hepatocyte Nucleus

2000 • 83 citations

Caged Nicotinic Acid Adenine Dinucleotide Phosphate

1997 • 83 citations

Transition State Structure of Salmonella typhimurium Orotate Phosphoribosyltransferase

1996 • 81 citations

The CD38/cyclic ADP-ribose system: A topological paradox

1997 • 80 citations

Extracellular cyclic ADP‐ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors

2000 • 77 citations

Accumulation of cyclic ADP‐ribose measured by a specific radioimmunoassay in differentiated human leukemic HL‐60 cells with all‐trans‐retinoic acid

1995 • 75 citations

Cyclic ADP-ribose and related compounds activate sheep skeletal sarcoplasmic reticulum Ca2+ release channel

1995 • 75 citations

Ca2+ stores in insulin-secreting cells: lack of effect of cADP ribose

1994 • 70 citations

Autoantibodies to CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in Caucasian patients with diabetes: effects on insulin release from human islets.

1999 • 70 citations

Calmodulin is a selective mediator of Ca(2+)-induced Ca2+ release via the ryanodine receptor-like Ca2+ channel triggered by cyclic ADP-ribose.

1995 • 69 citations

Structural Determinants of Nicotinic Acid Adenine Dinucleotide Phosphate Important for Its Calcium-mobilizing Activity

1997 • 68 citations

Actions of cADP-Ribose and Its Antagonists on Contraction in Guinea Pig Isolated Ventricular Myocytes

1997 • 67 citations

Pharmacology of Ca²⁺ release from red beet microsomes suggests the presence of ryanodine receptor homologs in higher plants

1996 • 67 citations

A Unified Mechanism of Enzymatic Synthesis of Two Calcium Messengers: Cyclic ADP-Ribose and NAADP

1999 • 65 citations

The cross-talk between nitric oxide and Ca2+: a story with a complex past and a promising future

1997 • 64 citations

A Covalent Intermediate in CD38 Is Responsible for ADP-Ribosylation and Cyclization Reactions

2000 • 63 citations

Enzyme Properties of Aplysia ADP-Ribosyl Cyclase: Comparison with NAD Glycohydrolase of CD38 Antigen1

1995 • 63 citations

Cyclic aristeromycin diphosphate ribose: A potent and poorly hydrolysable Ca²⁺‐mobilising mimic of cyclic adenosine diphosphate ribose

1996 • 63 citations

Characterization of the Active Site of ADP-ribosyl Cyclase

1999 • 62 citations

Cyclic ADP-ribose does not affect cardiac or skeletal muscle ryanodine receptors

1994 • 61 citations

Cyclic ADP-ribose Enhances Coupling between Voltage-gated Ca2+ Entry and Intracellular Ca2+ Release

1997 • 59 citations

Roles of Ca2+, inositol trisphosphate and cyclic ADP-ribose in mediating intercellular Ca2+ signaling in sheep lens cells

1998 • 59 citations

An Antagonist of cADP-ribose Inhibits Arrhythmogenic Oscillations of Intracellular Ca2+ In Heart Cells

1999 • 59 citations

Caged Cyclic ADP-Ribose

1995 • 58 citations

The release of intracellular Ca2+ in lacrimal acinar cells by ?-, ?-adrenergic and muscarinic cholinergic stimulation: the roles of inositol trisphosphate and cyclic ADP-ribose

1995 • 55 citations

Cyclic ADP-ribose: A calcium mobilizing metabolite of NAD+

1994 • 55 citations

Imaging of intracellular calcium stores in single permeabilized lens cells

1999 • 55 citations

The cyclic ADP ribose antagonist 8-NH 2 -cADP-ribose blocks cholecystokinin-evoked cytosolic Ca 2+ spiking in pancreatic acinar cells

1998 • 54 citations

Enhancing effect of calmodulin on Ca(2+)‐induced Ca2+ release in the sarcoplasmic reticulum of rabbit skeletal muscle fibres.

1995 • 53 citations

Cyclic ADP-Ribose Does Not Regulate Sarcoplasmic Reticulum Ca ²⁺ Release in Intact Cardiac Myocytes

1996 • 52 citations

Roles for Adenosine Ribose Hydroxyl Groups in Cyclic Adenosine 5‘-Diphosphate Ribose-Mediated Ca²⁺ Release

1997 • 52 citations

The Two Intracellular Ca2+Release Channels, Ryanodine Receptor and Inositol 1,4,5-Trisphosphate Receptor, Play Different Roles during Fertilization in Ascidians

1997 • 50 citations

NAADP: An Emerging Calcium Signaling Molecule

2000 • 48 citations

Cyclic ADP‐ribose and inositol 1,4,5‐trisphosphate mobilizes Ca²⁺ from distinct intracellular pools in permeabilized lacrimal acinar cells

1995 • 47 citations

Characterization and localization of CD38 in the vertebrate eye

1999 • 47 citations

Nicotinamide‐adenine dinucleotide regulates muscarinic receptor‐coupled K+ (M) channels in rodent NG108‐15 cells.

1995 • 45 citations

Cyclic 3-deaza-adenosine diphosphoribose: a potent and stable analog of cyclic ADP-ribose

1999 • 44 citations

Cyclic ADP-ribose activates caffeine-sensitive calcium channels from sea urchin egg microsomes

1998 • 44 citations

Separate Activation of the Cytoplasmic and Nuclear Calcium Pools in Maturing Starfish Oocytes

1998 • 44 citations

Oscillation of ADP‐ribosyl cyclase activity during the cell cycle and function of cyclic ADP‐ribose in a unicellular organism, Euglena gracilis

1997 • 41 citations

Insulin Exocytosis and Glucose-mediated Increase in Cytoplasmic Free Ca2+ Concentration in the Pancreatic β-Cell Are Independent of Cyclic ADP-ribose

1996 • 41 citations

Magnesium Ions But Not ATP Inhibit Cyclic ADP-Ribose-Induced Calcium Release

1995 • 40 citations

Untitled

1999 • 38 citations

Ryanodine receptor expression is associated with intracellular Ca²⁺ release in rat parotid acinar cells

1997 • 37 citations

Detection and functional characterization of ryanodine receptors from sea urchin eggs

1998 • 35 citations

Inositol trisphosphate and cyclic adenosine diphosphate-ribose increase quantal transmitter release at frog motor nerve terminals: possible involvement of smooth endoplasmic reticulum

1999 • 35 citations

Effects of photoreleased cADP-ribose on calcium transients and calcium sparks in myocytes isolated from guinea-pig and rat ventricle

1999 • 33 citations

Involvement of Cytosolic NAD+Glycohydrolase in Cyclic ADP-Ribose Metabolism

1998 • 31 citations

Metabotropic glutamate receptor activation and intracellular cyclic ADP-ribose release Ca2+from the same store in cultured DRG neurones

1999 • 30 citations

[20] Radioimmunoassay for measuring endogenous levels of cyclic ADP-ribose in tissues

1997 • 30 citations

Role of Cyclic ADP-Ribose in ATP-activated Potassium Currents in Alveolar Macrophages

1997 • 30 citations

Intracellular glucose switches between cyclic ADP-ribose and inositol trisphosphate triggering of cytosolic Ca2+ spiking

1998 • 30 citations

Characterization of Ryanodine-sensitive Ca 2+ Release from Microsomal Vesicles of Rat Parotid Acinar Cells: Regulation by Cyclic ADP-ribose

1997 • 29 citations

Mechanistic Implications of Cyclic ADP-Ribose Hydrolysis and Methanolysis Catalyzed by Calf Spleen NAD+Glycohydrolase

1994 • 27 citations

Untitled

1999 • 27 citations

The homo-dimeric form of ADP-ribosyl cyclase in solution

1998 • 24 citations

The cross-talk between nitric oxide and Ca2+: a story with a complex past and a promising future

1997 • 22 citations

Differential Utilization of Cyclic ADP-Ribose Pathway by Chemokines to Induce the Mobilization of Intracellular Calcium in NK Cells

1999 • 22 citations

Regulation of cADP-ribose-induced Ca2+ Release by Mg2+ and Inorganic Phosphate

1996 • 21 citations

Inositol 1,4,5-Trisphosphate and Cyclic ADP-Ribose Mobilize Ca2+ in a Protist, Euglena gracilis

1997 • 20 citations

Localization of Plasma Membrane CD38 Is Domain Specific in Rat Hepatocyte

2000 • 20 citations

[26] Bioassay for determining endogenous levels of cyclic ADP-ribose

1997 • 19 citations

Ryanodine and inositol trisphosphate receptors are differentially distributed and expressed in rat parotid gland

1999 • 19 citations

U73122 Blocked the cGMP-Induced Calcium Release in Sea Urchin Eggs

1998 • 18 citations

Fluorescent analogs of NAADP with calcium mobilizing activity

1998 • 18 citations

Lysophosphatidic acid-sensitive intracellular Ca2+ store does not regulate Ca2+ entry at plasma membrane in Jurkat human T-cells

1996 • 16 citations

Cyclic ADP-ribose and ABA signal transduction

1998 • 13 citations

Cyclic ADP-ribose Induces Ca2+ Release from Caffeine-insensitive Ca2+ Pools in Canine Salivary Gland Cells

1998 • 13 citations

Purification and Characterization of ADP-Ribosyl Cyclase from Euglena gracilis

1999 • 12 citations

Response

1993 • 12 citations

Crystallization of ADP‐ribosyl cyclase from Aplysia californica

1996 • 2 citations