Sarcoplasmic reticulum Ca release in intact ventricular myocytes
Data up to Jan 2025
Total Citations Per Year
Abstract
References (135)
Cardiac excitation–contraction coupling
2002 • 4,343 citations
PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor)
2000 • 1,940 citations
Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle
1993 • 1,917 citations
Excitation-Contraction Coupling and Cardiac Contractile Force
2010 • 1,661 citations
Excitation-Contraction Coupling and Cardiac Contractile Force
2001 • 1,509 citations
Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell.
1985 • 904 citations
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
1994 • 818 citations
Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, II
1999 • 815 citations
Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure
1997 • 754 citations
Arrhythmogenesis and Contractile Dysfunction in Heart Failure
2001 • 743 citations
Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions
1997 • 690 citations
Contractions induced by a calcium‐triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells.
1975 • 684 citations
Relaxation in rabbit and rat cardiac cells: species‐dependent differences in cellular mechanisms.
1994 • 661 citations
Theory of excitation-contraction coupling in cardiac muscle
1992 • 651 citations
Sodium Current-Induced Release of Calcium from Cardiac Sarcoplasmic Reticulum
1990 • 559 citations
The control of calcium release in heart muscle
1995 • 547 citations
Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes
1995 • 545 citations
FK506 binding protein associated with the calcium release channel (ryanodine receptor).
1992 • 525 citations
Calcium sparks and [Ca2+]i waves in cardiac myocytes
1996 • 524 citations
Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity
1991 • 499 citations
Rapid calcium release from cardiac sarcoplasmic reticulum vesicles is dependent on Ca2+ and is modulated by Mg2+, adenine nucleotide, and calmodulin.
1987 • 489 citations
Local calcium transients triggered by single L-type calcium channel currents in cardiac cells
1995 • 452 citations
Relationship Between Na + -Ca 2+ –Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium
1999 • 419 citations
Mechanism of release of calcium from sarcoplasmic reticulum of guinea‐pig cardiac cells.
1988 • 418 citations
Coupled Gating Between Individual Skeletal Muscle Ca 2+ Release Channels (Ryanodine Receptors)
1998 • 408 citations
Coupled Gating Between Cardiac Calcium Release Channels (Ryanodine Receptors)
2001 • 396 citations
Upregulation of Na + /Ca 2+ Exchanger Expression and Function in an Arrhythmogenic Rabbit Model of Heart Failure
1999 • 396 citations
Regulation of the Cardiac Ryanodine Receptor Channel by Luminal Ca2+ Involves Luminal Ca2+ Sensing Sites
1998 • 393 citations
Ca 2+ Handling and Sarcoplasmic Reticulum Ca 2+ Content in Isolated Failing and Nonfailing Human Myocardium
1999 • 370 citations
Spatial non-uniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes
1994 • 363 citations
The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum.
1993 • 353 citations
Rapid Adaptation of Cardiac Ryanodine Receptors: Modulation by Mg 2+ and Phosphorylation
1995 • 349 citations
Ryanodine Receptor Adaptation: Control Mechanism of Ca 2+ -Induced Ca 2+ Release in Heart
1993 • 328 citations
Surface:volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: species-dependence and developmental effects
1996 • 322 citations
Distribution of Proteins Implicated in Excitation-Contraction Coupling in Rat Ventricular Myocytes
2000 • 320 citations
Integrative Analysis of Calcium Cycling in Cardiac Muscle
2000 • 302 citations
Calmodulin activation and inhibition of skeletal muscle Ca2+ release channel (ryanodine receptor)
1995 • 299 citations
Single cardiac sarcoplasmic reticulum Ca2+-release channel: activation by caffeine
1989 • 288 citations
Phosphorylation Modulates the Function of the Calcium Release Channel of Sarcoplasmic Reticulum from Cardiac Muscle
1995 • 286 citations
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy
2002 • 279 citations
Decreased Sarcoplasmic Reticulum Calcium Content Is Responsible for Defective Excitation-Contraction Coupling in Canine Heart Failure
2001 • 274 citations
A nuclear magnetic resonance study of metabolism in the ferret heart during hypoxia and inhibition of glycolysis.
1985 • 264 citations
Selective Binding of FKBP12.6 by the Cardiac Ryanodine Receptor
1996 • 249 citations
Ryanodine Receptor of Skeletal Muscle Is a Gap Junction-Type Channel
1988 • 231 citations
Cytosolic Free Magnesium Levels in Ischemic Rat Heart
1989 • 230 citations
Cardiac Intracellular Calcium Release Channels
2000 • 222 citations
Altered Stoichiometry of FKBP12.6 Versus Ryanodine Receptor as a Cause of Abnormal Ca 2+ Leak Through Ryanodine Receptor in Heart Failure
2000 • 221 citations
Ratio of ryanodine to dihydropyridine receptors in cardiac and skeletal muscle and implications for E-C coupling
1993 • 218 citations
Calmodulin Binding and Inhibition of Cardiac Muscle Calcium Release Channel (Ryanodine Receptor)
2001 • 217 citations
Effects of [Ca2+]i, SR Ca2+ load, and rest on Ca2+ spark frequency in ventricular myocytes
1997 • 210 citations
Regulation of calcium release by calcium inside the sarcoplasmic reticulum in ventricular myocytes
1996 • 204 citations
Regulation of Cardiac Ca 2+ Release Channel (Ryanodine Receptor) by Ca 2+ , H + , Mg 2+ , and Adenine Nucleotides Under Normal and Simulated Ischemic Conditions
1996 • 196 citations
Low Efficiency of Ca 2+ Entry Through the Na + -Ca 2+ Exchanger as Trigger for Ca 2+ Release From the Sarcoplasmic Reticulum
1997 • 194 citations
Sodium current‐induced calcium signals in isolated guinea‐pig ventricular myocytes.
1994 • 184 citations
Sarcoplasmic reticulum lumenal Ca2+ has access to cytosolic activation and inactivation sites of skeletal muscle Ca2+ release channel
1996 • 184 citations
Submicroscopic calcium signals as fundamental events of excitation‐‐contraction coupling in guinea‐pig cardiac myocytes.
1996 • 182 citations
The immunophilin FK506‐binding protein modulates Ca2+ release channel closure in rat heart.
1997 • 182 citations
Effects of Rapamycin on Ryanodine Receptor/Ca 2+ -Release Channels From Cardiac Muscle
1996 • 177 citations
Termination of Ca 2+ release by a local inactivation of ryanodine receptors in cardiac myocytes
1998 • 172 citations
Na-Ca Exchange and the Trigger for Sarcoplasmic Reticulum Ca Release: Studies in Adult Rabbit Ventricular Myocytes
1998 • 172 citations
Modulation of cardiac ryanodine receptors of swine and rabbit by a phosphorylation‐dephosphorylation mechanism.
1995 • 172 citations
Regulation of the gating of the sheep cardiac sarcoplasmic reticulum ca2+-release channel by luminal Ca2+
1994 • 170 citations
The relative contributions of different intracellular and sarcolemmal systems to relaxation in rat ventricular myocytes
1993 • 169 citations
Local, stochastic release of Ca2+ in voltage‐clamped rat heart cells: visualization with confocal microscopy.
1994 • 168 citations
Ca2+ sparks and Ca2+ waves in saponin‐permeabilized rat ventricular myocytes
1999 • 167 citations
Modulation of CICR has no maintained effect on systolic Ca2+: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca2+ fluxes in rat ventricular myocytes
2000 • 167 citations
Calcium Content of the Sarcoplasmic Reticulum in Isolated Ventricular Myocytes from Patients with Terminal Heart Failure
1998 • 163 citations
Numerical simulation of local calcium movements during L-type calcium channel gating in the cardiac diad
1997 • 163 citations
The effect of Ca2+–calmodulin‐dependent protein kinase II on cardiac excitation–contraction coupling in ferret ventricular myocytes
1997 • 162 citations
Direct measurement of SR release flux by tracking ‘Ca2+ spikes’ in rat cardiac myocytes
1998 • 161 citations
Modulation of Cardiac Ryanodine Receptors by Sorcin
1997 • 160 citations
Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes.
1997 • 159 citations
Association of Sorcin With the Cardiac Ryanodine Receptor
1995 • 154 citations
Gating of the Cardiac Ca 2+ Release Channel: the Role of Na + Current and Na + -Ca 2+ Exchange
1992 • 150 citations
Regulation of Cardiac Muscle Ca2+ Release Channel by Sarcoplasmic Reticulum Lumenal Ca2+
1998 • 149 citations
Ca2+ sparks involving multiple Ca2+ release sites along Z‐lines in rat heart cells.
1996 • 148 citations
Single channel activity of the ryanodine receptor calcium release channel is modulated by FK‐506
1994 • 148 citations
Dynamic Regulation of Sarcoplasmic Reticulum Ca2+ Content and Release by Luminal Ca2+-Sensitive Leak in Rat Ventricular Myocytes
2001 • 147 citations
Depolarization-induced Ca entry via Na-Ca exchange triggers SR release in guinea pig cardiac myocytes
1994 • 145 citations
β-Adrenergic Stimulation Synchronizes Intracellular Ca 2+ Release During Excitation-Contraction Coupling in Cardiac Myocytes
2001 • 142 citations
Evidence of a role for calmodulin in the regulation of calcium release from skeletal muscle sarcoplasmic reticulum
1986 • 139 citations
Regulation of Current Flow through Ryanodine Receptors by Luminal Ca 2+
1997 • 138 citations
A novel, rapid and reversible method to measure Ca buffering and time-course of total sarcoplasmic reticulum Ca content in cardiac ventricular myocytes
1999 • 135 citations
Steady-state twitch Ca2+ fluxes and cytosolic Ca2+ buffering in rabbit ventricular myocytes
1996 • 135 citations
The Ryanodine Receptor from Canine Heart Sarcoplasmic Reticulum Is Associated with a Novel FK-506 Binding Protein
1994 • 133 citations
Cellular and functional defects in a mouse model of heart failure
2000 • 124 citations
Passive Ca buffering and SR Ca uptake in permeabilized rabbit ventricular myocytes
1993 • 124 citations
Ca2+ -currents and intracellular [Ca2+]i-transients in single ventricular myocytes isolated from terminally failing human myocardium
1992 • 119 citations
Sorcin Associates with the Pore-forming Subunit of Voltage-dependent L-type Ca2+ Channels
1998 • 117 citations
Properties of Ca2+ sparks evoked by action potentials in mouse ventricular myocytes
1999 • 117 citations
Different interactions of cardiac and skeletal muscle ryanodine receptors with FK-506 binding protein isoforms
1997 • 114 citations
Assessment of intra-SR free [Ca] and buffering in rat heart
1997 • 113 citations
Regulation of RYR1 Activity by Ca2+ and Calmodulin
2000 • 111 citations
Effects of FK-506 on Contraction and Ca 2+ Transients in Rat Cardiac Myocytes
1996 • 109 citations
Ca2+ load of guinea‐pig ventricular myocytes determines efficacy of brief Ca2+ currents as trigger for Ca2+ release.
1994 • 108 citations
Impaired Contractile Performance of Cultured Rabbit Ventricular Myocytes After Adenoviral Gene Transfer of Na + -Ca 2+ Exchanger
2000 • 106 citations
Stoichiometry of Na+‐Ca2+ exchange in inside‐out patches excised from guinea‐pig ventricular myocytes
2000 • 102 citations
Role of sodium‐calcium exchange in activation of contraction in rat ventricle.
1993 • 98 citations
Rate of diastolic Ca release from the sarcoplasmic reticulum of intact rabbit and rat ventricular myocytes
1995 • 97 citations
Measurement of Free Ca2+ in Sarcoplasmic Reticulum in Perfused Rabbit Heart Loaded with 1,2-Bis(2-amino-5,6-difluorophenoxy)ethane-N,N,N′,N′-tetraacetic Acid by 19F NMR
1996 • 96 citations
Contractile Reserve and Intracellular Calcium Regulation in Mouse Myocytes From Normal and Hypertrophied Failing Hearts
2000 • 92 citations
Ca2+ activation and Ca2+ inactivation of canine reconstituted cardiac sarcoplasmic reticulum Ca(2+)‐release channels.
1995 • 89 citations
Dynamic modulation of excitation‐contraction coupling by protein phosphatases in rat ventricular myocytes.
1996 • 87 citations
Paradoxical Twitch Potentiation After Rest in Cardiac Muscle: Increased Fractional Release of SR Calcium
1993 • 86 citations
Identification of the Minimum Essential Region in the II-III Loop of the Dihydropyridine Receptor α1 Subunit Required for Activation of Skeletal Muscle-Type Excitation−Contraction Coupling
1998 • 79 citations
The effect of tetracaine on stimulated contractions, sarcoplasmic reticulum Ca2+ content and membrane current in isolated rat ventricular myocytes
1998 • 78 citations
Release of calcium from guinea pig cardiac sarcoplasmic reticulum induced by sodium-calcium exchange
1994 • 75 citations
Inhibition of Ca2+ Sparks by Ruthenium Red in Permeabilized Rat Ventricular Myocytes
2000 • 73 citations
Modulation of intracellular Ca2+ levels in the heart by sorcin and FKBP12, two accessory proteins of ryanodine receptors
1998 • 72 citations
Rapid Activation of the Cardiac Ryanodine Receptor by Submillisecond Calcium Stimuli
1999 • 70 citations
Transmission of Information From Cardiac Dihydropyridine Receptor to Ryanodine Receptor
2000 • 67 citations
Effects of Na+/Ca2+-exchanger Overexpression on Excitation–contraction Coupling in Adult Rabbit Ventricular Myocytes
2002 • 61 citations
Calcium-dependent block of ryanodine receptor channel of swine skeletal muscle by direct binding of calmodulin
1994 • 58 citations
Na+ current and Ca2+ release from the sarcoplasmic reticulum during action potentials in guinea‐pig ventricular myocytes.
1995 • 58 citations
Control of Maximum Sarcoplasmic Reticulum Ca Load in Intact Ferret Ventricular Myocytes
1998 • 56 citations
Asymmetrical blockade of the Ca2+ release channel (ryanodine receptor) by 12-kDa FK506 binding protein.
1994 • 54 citations
A carboxy-terminal peptide of the alpha 1-subunit of the dihydropyridine receptor inhibits Ca(2+)-release channels
1997 • 52 citations
Calcium fluxes across the membrane of sarcoplasmic reticulum vesicles.
1982 • 48 citations
Control of sarcoplasmic reticulum calcium release during calcium loading in isolated rat ventricular myocytes.
1995 • 46 citations
New Insights Into the Gating Mechanisms of Cardiac Ryanodine Receptors Revealed by Rapid Changes in Ligand Concentration
1995 • 46 citations
Diffusion around a cardiac calcium channel and the role of surface bound calcium
1991 • 44 citations
Bay K 8644 Increases Resting Ca 2+ Spark Frequency in Ferret Ventricular Myocytes Independent of Ca Influx
1998 • 44 citations
Paradoxical block of the Na+‐Ca2+ exchanger by extracellular protons in guinea‐pig ventricular myocytes
2000 • 43 citations
Inhibition of calcium release from skeletal muscle sarcoplasmic reticulum by calmodulin
1988 • 32 citations
Possible Functional Linkage Between the Cardiac Dihydropyridine and Ryanodine Receptor: Acceleration of Rest Decay by Bay K 8644
1996 • 27 citations
Rapid calcium release from cardiac sarcoplasmic reticulum vesicles is dependent on Ca2+ and is modulated by Mg2+, adenine nucleotide, and calmodulin.
1987 • 27 citations
Effects of dihydropyridine receptor II-III loop peptides on Ca2+release in skinned skeletal muscle fibers
2000 • 27 citations
BAY K 8644 depresses excitation-contraction coupling in cardiac muscle
1996 • 19 citations
Possible inhibition of canine ventricular sarcoplasmic reticulum by BAY K 8644
1989 • 17 citations
Calmodulin activation and inhibition of skeletal muscle Ca2+ release channel (ryanodine receptor)
1995 • 15 citations
Undirectional calcium and nucleotide fluxes in cardiac sarcoplasmic reticulum. II. Experimental results
1984 • 14 citations
Altered Stoichiometry of FKBP12.6 Versus Ryanodine Receptor as a Cause of Abnormal Ca2+ Leak Through Ryanodine Receptor in Heart Failure
2000 • 14 citations
Regulation of Cardiac Muscle Ca 2+ Release Channel by Sarcoplasmic Reticulum Lumenal Ca 2+
1998 • 11 citations
Inhibition of rest potentiation in canine ventricular muscle by BAY K 8644: comparison with caffeine
1989 • 9 citations
Regulation of Cardiac Ca2+ Release Channel (Ryanodine Receptor) by Ca2+, H+, Mg2+, and Adenine Nucleotides Under Normal and Simulated Ischemic Conditions
1996 • 8 citations