Mechanisms and experimental and epidemiological evidence relating dietary fibre (non-starch polysaccharides) and starch to protection against large bowel cancer

Cancer Incidence in Five Continents

1970 • 8,763 citations

Revised methods for the Salmonella mutagenicity test

1983 • 7,295 citations

Cancer Incidence in Five Continents

1966 • 5,960 citations

Short chain fatty acids in human large intestine, portal, hepatic and venous blood.

1987 • 2,744 citations

Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices

1975 • 2,207 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man.

1980 • 1,265 citations

Short chain fatty acids in the human colon.

1981 • 1,037 citations

Determination of the non-starch polysaccharides in plant foods by gas-liquid chromatography of constituent sugars as alditol acetates

1982 • 833 citations

Effects of sodium butyrate, a new pharmacological agent, on cells in culture

1981 • 808 citations

Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors

1987 • 656 citations

Normal Indigenous Intestinal Flora

1983 • 628 citations

Role of life-style and dietary habits in risk of cancer among seventh-day adventists.

1975 • 588 citations

Environmental factors of cancer of the colon and rectum

1967 • 572 citations

Chromosome 5 allele loss in human colorectal carcinomas

1987 • 566 citations

Digestion of the polysaccharides of some cereal foods in the human small intestine

1985 • 516 citations

Mechanism of action of dietary fibre in the human colon

1980 • 496 citations

Large-Bowel Cancer in Hawaiian Japanese2

1973 • 492 citations

Protein Degradation by Human Intestinal Bacteria

1986 • 439 citations

Diet in the Epidemiology of Cancer of the Colon and Rectum<xref ref-type="fn" rid="FN2">2</xref>

1978 • 423 citations

Human intestinal microflora in health and disease

1985 • 417 citations

Digestion of polysaccharides of potato in the small intestine of man

1987 • 400 citations

Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process

1985 • 373 citations

Environmental factors of cancer of the colon and rectumII. Japanese epidemiological data

1969 • 370 citations

Diet and Cancer of the Colon and Rectum: A Case-Control Study

1986 • 351 citations

The effect of meat protein and dietary fiber on colonic function and metabolism II. Bacterial metabolites in feces and urine

1979 • 347 citations

Case‐control study of dietary etiological factors: The Melbourne colorectal cancer study

1987 • 338 citations

RELATED DISEASE—RELATED CAUSE?

1969 • 314 citations

Diet and colorectal cancer: A case‐control study in Greece

1983 • 307 citations

A case‐control study of diet and colo‐rectal cancer

1980 • 303 citations

Effects of short chain fatty acids on a new human colon carcinoma cell line (LIM1215).

1986 • 296 citations

Role of the Gut Flora in Toxicity and Cancer

1988 • 284 citations

Polysaccharide breakdown by mixed populations of human faecal bacteria

1987 • 284 citations

Changes in fecal composition and colonic function due to cereal fiber

1976 • 284 citations

Digestion of the carbohydrates of banana (Musa paradisiaca sapientum) in the human small intestine

1986 • 283 citations

A CASE-CONTROL STUDY OF RELATIONSHIPS OF DIET AND OTHER TRAITS TO COLORECTAL CANCER IN AMERICAN BLACKS1

1979 • 278 citations

Case‐control study on colorectal cancer and diet in marseilles

1986 • 274 citations

Low-Fiber Intake as an Etiologic Factor in Cancer of the Colon 2

1975 • 251 citations

Cancer Incidence in the Bantu and “Cape Colored” Races of South Africa: Report of a Cancer Survey in the Transvaal (1953–55)2

1960 • 251 citations

Food items and food groups as risk factors in a case‐control study of diet and colo‐rectal cancer

1983 • 250 citations

Occurrence of sulphate‐reducing bacteria in human faeces and the relationship of dissimilatory sulphate reduction to methanogenesis in the large gut

1988 • 240 citations

Diet and cell growth modulation by ammonia

1978 • 238 citations

Case‐control study of proximal and distal colon cancer and diet in Wisconsin

1988 • 232 citations

DIETARY EPIDEMIOLOGY OF CANCER OF THE COLON IN WESTERN NEW YORK

1988 • 224 citations

Colorectal cancer and diet in an asian population—A case‐control study among Singapore Chinese

1989 • 222 citations

HIGH COLONIC pH PROMOTES COLORECTAL CANCER

1981 • 220 citations

PHYSICAL ACTIVITY, DIET, AND RISK OF COLON CANCER IN UTAH

1988 • 213 citations

Etiological Factors in Gastrointestinal Cancer in Man<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1966 • 212 citations

Colorectal cancer and the consumption of foods: A case‐control study in Belgium

1988 • 211 citations

Fate of soluble carbohydrate in the colon of rats and man.

1976 • 198 citations

Colorimetric method for routine measurement of dietary fibre as non-starch polysaccharides. A comparison with gas-liquid chromatography

1987 • 191 citations

Dietary factors in colon cancer: International relationships

1985 • 187 citations

Competition for hydrogen between sulphate-reducing bacteria and methanogenic bacteria from the human large intestine

1988 • 166 citations

Recent hypotheses for the origin of colon cancer.

1987 • 158 citations

Colorectal cancer and the intake of nutrients: Oligosaccharides are a risk factor, fats are not. A case‐control study in Belgium

1987 • 158 citations

Inhibition of Carcinogenesis by minor Anutrient Constituents of the Diet

1990 • 154 citations

Effects of calcium and pH on the mucosal damage produced by deoxycholic acid in the rat colon.

1986 • 147 citations

Dietary fibre (non‐starch polysaccharides) in fruit, vegetables and nuts

1988 • 145 citations

The Effect of Starch Malabsorption on Fecal Short-Chain Fatty Acid Excretion in Man

1988 • 144 citations

Sugar, fat, and the risk of colorectal cancer.

1985 • 140 citations

Effects of intraluminal infusion of short-chain fatty acids on the healing of colonic anastomosis in the rat.

1986 • 135 citations

Early induction of rat colonic epithelial ornithine and S-adenosyl-L-methionine decarboxylase activities by N-methyl-N'-nitro-N-nitrosoguanidine or bile salts.

1981 • 128 citations

Colorectal cancer in rural Nebraska.

1984 • 127 citations

Effect of growth and sodium butyrate on brush border membrane-associated hydrolases in human colorectal cancer cell lines.

1985 • 127 citations

Energy intake: its relationship to colon cancer risk.

1987 • 126 citations

Dietary fibre (non‐starch polysaccharides) in cereal products

1989 • 125 citations

Bile salt stimulation of colonic epithelial proliferation. Evidence for involvement of lipoxygenase products.

1984 • 123 citations

BREATH-METHANE IN PATIENTS WITH CANCER OF THE LARGE BOWEL

1977 • 122 citations

Faecal pH, dietary fibre intake, and proneness to colon cancer in four South African populations

1986 • 112 citations

The regulation of protein kinase C by chenodeoxycholate, deoxycholate and several structurally related bile acids

1987 • 110 citations

Does dietary fibre stimulate intestinal epithelial cell proliferation in germ free rats?

1989 • 108 citations

Breath methane and large bowel cancer risk in contrasting African populations.

1988 • 102 citations

Carcinogenicity in mice and rats of heterocyclic amines in cooked foods.

1986 • 102 citations

Fat and essential fatty acid in mammary carcinogenesis

1987 • 100 citations

Effect of in vitro fermentation using human faecal inoculum on the water-holding capacity of dietary fibre

1985 • 100 citations

TRANSPORT OF UREA AND AMMONIA PRODUCTION IN THE HUMAN COLON

1971 • 97 citations

Dietary fibre, fibre-depleted foods and disease

1985 • 93 citations

Effects of differing concentrations of sodium butyrate on 1,2-dimethylhydrazine-induced rat intestinal neoplasia

1986 • 91 citations

Dietary fibre consumption in Britain: New estimates and their relation to large bowel cancer mortality

1985 • 87 citations

Etiological Factors in Gastrointestinal Cancer in Man

1967 • 80 citations

Dietary Fibre, Fibre-depleted Foods and Disease

1986 • 78 citations

Metabolic epidemiology of colon cancer: effect of dietary fiber on fecal mutagens and bile acids in healthy subjects.

1987 • 63 citations

n-Butyrate alters chromatin accessibility to DNA repair enzymes

1986 • 63 citations

Diet, fecal bile acids, and neutral sterols in carcinoma of the colon

1979 • 62 citations

The Contribution of Endogenous urea to Faecal Ammonia in man, Determined by 15N Labelling of Plasma Urea

1985 • 60 citations

Major Colorectal Cancer Aetiological Hypotheses Do Not Explain Mortality Trends among Maori and Non-Maori New Zealanders

1985 • 50 citations

The effect of income on the structure of the diet.

1969 • 49 citations

Expression of carcinoembryonic antigen by adenoma and carcinoma derived epithelial cell lines: possible marker of tumour progression and modulation of expression by sodium butyrate

1988 • 41 citations

Factors Associated with Adenocarcinomas of the Large Bowel in Puerto Rico

1979 • 38 citations

Binding of ¹⁴C‐Labeled Food Mutagens (IQ, MeIQ, MeIQx) by Dietary Fiber In Vitro

1985 • 32 citations

EPIDEMIOLOGY OF FECAL MUTAGENICITY1

1986 • 31 citations

Inactivity of fecapentaene-12 as a rodent carcinogen or tumor initiator

1988 • 30 citations

Dietary factors in colon cancer: International relationships. An update

1985 • 30 citations

Dietary fibre and large bowel cancer

1981 • 29 citations

Relationship of bile salt stimulation of colonic epithelial phospholipid turnover and proliferative activity: Role of activation of protein kinase C

1987 • 28 citations

Effect of Handling and Packaging on the Quality of Frozen Whitefish

1985 • 26 citations

Damaging Effect of Dietary Components to Colon Epithelial Cells In Vivo: Effect of Mutagenic Heterocyclic Amines<xref ref-type="fn" rid="FN2">2</xref>

1984 • 25 citations

Use of blue cotton for detection of mutagenicity in human feces excreted after ingestion of cooked meat.

1986 • 25 citations

Mutagens in Human Faeces and Cancer of the Large Bowel

1988 • 24 citations

Diet and faecal genotoxicity.

1987 • 24 citations

Dietary fibre intake in Japan.

1983 • 23 citations

Dietary fiber in the Japanese diet as investigated in connection with colon cancer risk.

1986 • 20 citations

Pilot study of the effect of diet on the mutagenicity of human faeces

1986 • 20 citations

Dietary fibre and fibre fractions in the diet of Finnish diabetic and non-diabetic adolescents.

1988 • 18 citations

An epidemiological study on relationship between intake of dietary fiber and colorectal cancer.

1987 • 10 citations

Oncology 1970. Being the Proceedings of the Tenth International Cancer Congress.

1972 • 10 citations

Diverticular disease, carcinoma of the colon and diet in urban and rural Kenya Africans.

1980 • 9 citations

Dietary Patterns and Cancer of the Digestive Tract in Older Patients†

1980 • 7 citations

Effects of purified cellulose and pectin fiber diets on mutagenicity of feces and luminal contents of stomach, small and large bowel in rats.

1983 • 7 citations

Dietary and Endogenous Sulphate Losses from the Upper Gastrointestinal Tract

1989 • 3 citations

Total Hydrogen (H2) and Methane (CH4) Production from Fermentation in Man Measured in a Whole Body Calorimeter

1989 • 2 citations

CURRENT RESEARCH ON FECAL MUTAGENICITY

1988 • 2 citations

[Reliability of perfusion manometry in the gastro-esophageal closure mechanism (author's transl)].

1980 • 1 citations