Enhancement of anti‐tumor immunity through local modulation of CTLA‐4 and GITR by dendritic cells

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

2010 • 14,016 citations

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

2010 • 5,069 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

Effector and memory T-cell differentiation: implications for vaccine development

2002 • 1,757 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

2003 • 1,564 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

2003 • 981 citations

Enterocolitis in Patients With Cancer After Antibody Blockade of Cytotoxic T-Lymphocyte–Associated Antigen 4

2006 • 812 citations

Cutting Edge: CD4+CD25+ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis

2002 • 779 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

2006 • 677 citations

Ipilimumab (Anti-CTLA4 Antibody) Causes Regression of Metastatic Renal Cell Cancer Associated With Enteritis and Hypophysitis

2007 • 673 citations

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients

2008 • 639 citations

Immunostimulatory monoclonal antibodies for cancer therapy

2007 • 596 citations

Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells

2004 • 498 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

2012 • 462 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+regulatory T cells

2005 • 451 citations

Autoimmunity in a Phase I Trial of a Fully Human Anti-Cytotoxic T-Lymphocyte Antigen-4 Monoclonal Antibody With Multiple Melanoma Peptides and Montanide ISA 51 for Patients With Resected Stages III and IV Melanoma

2004 • 432 citations

A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis

1997 • 410 citations

A Pilot Trial of CTLA-4 Blockade with Human Anti-CTLA-4 in Patients with Hormone-Refractory Prostate Cancer

2007 • 397 citations

Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations

2004 • 358 citations

Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells

2003 • 353 citations

Cytotoxic T-Lymphocyte-Associated Antigen-4 Blockage Can Induce Autoimmune Hypophysitis in Patients With Metastatic Melanoma and Renal Cancer

2005 • 350 citations

A high molecular weight protease in the cytosol of rat liver. I. Purification, enzymological properties, and tissue distribution.

1986 • 327 citations

Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients

2006 • 302 citations

Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells

2004 • 288 citations

Review: Anti–CTLA-4 Antibody Ipilimumab: Case Studies of Clinical Response and Immune-Related Adverse Events

2007 • 280 citations

The GITR–GITRL interaction: co-stimulation or contrasuppression of regulatory activity?

2006 • 276 citations

Intrapatient Dose Escalation of Anti–CTLA-4 Antibody in Patients With Metastatic Melanoma

2006 • 261 citations

Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation

2010 • 249 citations

Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8+ T-Cell Responses and Tumor Immunity

2006 • 201 citations

Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity.

2003 • 185 citations

GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily

2005 • 173 citations

Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity

2006 • 172 citations

T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy

2008 • 171 citations

Differential expression of CTLA-4 among T cell subsets

2004 • 162 citations

Biologic and immunomodulatory events after CTLA‐4 blockade with ticilimumab in patients with advanced malignant melanoma

2006 • 147 citations

Vaccination against the Forkhead Family Transcription Factor Foxp3 Enhances Tumor Immunity

2007 • 146 citations

Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals

2010 • 133 citations

Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion

2009 • 128 citations

Intratumoral Immune Cell Infiltrates, FoxP3, and Indoleamine 2,3-Dioxygenase in Patients with Melanoma Undergoing CTLA4 Blockade

2008 • 124 citations

Pivotal Roles of CD4+ Effector T cells in Mediating Agonistic Anti-GITR mAb-Induced-Immune Activation and Tumor Immunity in CT26 Tumors

2007 • 106 citations

Naturally Arising CD25+CD4+ Regulatory T Cells in Tumor Immunity

2005 • 90 citations

Regulatory T Cell–Resistant CD8+ T Cells Induced by Glucocorticoid-Induced Tumor Necrosis Factor Receptor Signaling

2008 • 85 citations

Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells

2007 • 69 citations

Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity

2007 • 59 citations

Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy

2009 • 51 citations

The Role of the CTLA4 Blockade in the Treatment of Malignant Melanoma

2007 • 48 citations

In vivo ligation of glucocorticoid-induced TNF receptor enhances the T-cell immunity to herpes simplex virus type 1

2005 • 37 citations

Activated B cells modified by electroporation of multiple mRNAs encoding immune stimulatory molecules are comparable to mature dendritic cells in inducing in vitro antigen‐specific T‐cell responses

2008 • 36 citations

Conversion of Alloantigen-Specific CD8+ T Cell Anergy to CD8+ T Cell Priming through In Vivo Ligation of Glucocorticoid-Induced TNF Receptor

2006 • 33 citations

Role of anti-CTLA-4 therapies in the treatment of cancer.

2004 • 19 citations