Differential expression of CTLA-4 among T cell subsets

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR Engagement

1996 • 583 citations

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

1983 • 441 citations

CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.

1991 • 422 citations

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

1998 • 359 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 334 citations

Tyrosine Phosphorylation Controls Internalization of CTLA-4 by Regulating Its Interaction with Clathrin-Associated Adaptor Complex AP-2

1997 • 334 citations

Characterization of CTLA-4 structure and expression on human T cells.

1993 • 319 citations

CD28, CTLA‐4 and their ligands: who does what and to whom?

2000 • 317 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 294 citations

Is CTLA-4 a master switch for peripheral T cell tolerance?

1997 • 284 citations

Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells

2002 • 246 citations

Cutting Edge: Lymphoproliferative Disease in the Absence of CTLA-4 Is Not T Cell Autonomous

1999 • 236 citations

Structural Analysis of CTLA-4 Function In Vivo

2000 • 236 citations

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.

1992 • 153 citations

Cytotoxic T Lymphocyte Antigen 4 and CD28 Modulate Cell Surface Raft Expression in Their Regulation of T Cell Function

2001 • 136 citations

Interaction of the Cytoplasmic Tail of CTLA-4 (CD152) with a Clathrin-Associated Protein Is Negatively Regulated by Tyrosine Phosphorylation

1997 • 126 citations

Regulation of Surface and Intracellular Expression of CTLA‐4 on Human Peripheral T Cells

2001 • 87 citations

Complete Sequence Determination of the Mouse and Human CTLA4 Gene Loci: Cross-Species DNA Sequence Similarity beyond Exon Borders

1999 • 76 citations

Differential Role of CTLA-4 in Regulation of Resting Memory Versus Naive CD4 T Cell Activation

1998 • 66 citations

Dissociation of T cell anergy from apoptosis by blockade of Fas/Apo-1 (CD95) signaling.

1997 • 45 citations

CTLA-4 blockade of antigen-induced cell death

2001 • 31 citations