Pivotal Roles of CD4+ Effector T cells in Mediating Agonistic Anti-GITR mAb-Induced-Immune Activation and Tumor Immunity in CT26 Tumors

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

CD107a as a functional marker for the identification of natural killer cell activity

2004 • 1,321 citations

TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

2004 • 1,320 citations

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

2002 • 1,163 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

2007 • 887 citations

Tolerance, not immunity, crucially depends on IL-2

2004 • 826 citations

Helping the CD8+ T-cell response

2004 • 775 citations

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signalsin vivo

2004 • 761 citations

CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells

2005 • 741 citations

Increased Populations of Regulatory T Cells in Peripheral Blood of Patients with Hepatocellular Carcinoma

2005 • 618 citations

Immunostimulatory monoclonal antibodies for cancer therapy

2007 • 596 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells

2004 • 498 citations

Regulatory T Cells Reversibly Suppress Cytotoxic T Cell Function Independent of Effector Differentiation

2006 • 475 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

2012 • 462 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+regulatory T cells

2005 • 451 citations

CD4 cells can be more efficient at tumor rejection than CD8 cells

2007 • 411 citations

Ex vivo identification, isolation and analysis of tumor-cytolytic T cells

2003 • 410 citations

Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

2005 • 406 citations

CD4+CD25+ T Regulatory Cells Suppress NK Cell-Mediated Immunotherapy of Cancer

2006 • 395 citations

COOPERATION BETWEEN CD4⁺AND CD8⁺T CELLS: When, Where, and How

2006 • 365 citations

Frontline: GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations

2004 • 358 citations

Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells

2004 • 288 citations

The GITR–GITRL interaction: co-stimulation or contrasuppression of regulatory activity?

2006 • 276 citations

Expression of FoxP3, a key molecule in CD4⁺CD25⁺ regulatory T cells, in adult T‐cell leukaemia/lymphoma cells

2004 • 276 citations

Cutting Edge: The Natural Ligand for Glucocorticoid-Induced TNF Receptor-Related Protein Abrogates Regulatory T Cell Suppression

2004 • 202 citations

Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8+ T-Cell Responses and Tumor Immunity

2006 • 201 citations

OX40 ligand shuts down IL-10-producing regulatory T cells

2006 • 193 citations

Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity

2006 • 172 citations

Visualization and quantification of T cell–mediated cytotoxicity using cell-permeable fluorogenic caspase substrates

2002 • 160 citations

Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)

2006 • 157 citations

Anti-CD40 Antibody Induces Antitumor and Antimetastatic Effects: The Role of NK Cells

2001 • 108 citations

Functional Dichotomy between OX40 and 4-1BB in Modulating Effector CD8 T Cell Responses

2006 • 103 citations

A sensitive flow cytometry-based cytotoxic T-lymphocyte assay through detection of cleaved caspase 3 in target cells

2005 • 80 citations

Immunosurveillance ofErbb2Carcinogenesis in Transgenic Mice Is Concealed by a Dominant Regulatory T-Cell Self-Tolerance

2006 • 78 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3[+]CD25[+]CD4[+] regulatory T cells

2006 • 70 citations

Distinct and Overlapping Roles of Interleukin-10 and CD25+ Regulatory T Cells in the Inhibition of Antitumor CD8 T-Cell Responses

2005 • 66 citations

Engagement of Glucocorticoid-Induced TNF Receptor Costimulates NKT Cell Activation In Vitro and In Vivo

2006 • 45 citations

CD73 and Ly-6A/E Distinguish In Vivo Primed but Uncommitted Mouse CD4 T Cells from Type 1 or Type 2 Effector Cells

2005 • 31 citations