Signal transmission by epidermal growth factor receptor: coincidence of activation and dimerization

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots

1984 • 2,189 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Epidermal growth factor.

1990 • 1,645 citations

Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.

1977 • 1,579 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431.

1978 • 578 citations

Separation and Characterization of the Subunits of Ribonucleic Acid Polymerase

1969 • 520 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Expression of epidermal growth factor receptors in human brain tumors.

1984 • 478 citations

Signal transduction by allosteric receptor oligomerization

1988 • 410 citations

The erbB gene of avian erythroblastosis virus is a member of the src gene family

1983 • 377 citations

Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells

1984 • 296 citations

Antibodies specific for the carboxy- and amino-terminal regions of simian virus 40 large tumor antigen.

1980 • 262 citations

Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies

1988 • 248 citations

Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent.

1988 • 228 citations

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells.

1986 • 222 citations

A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction.

1988 • 215 citations

Epidermal growth factor and its receptor

1987 • 197 citations

Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylation.

1989 • 193 citations

Immunoaffinity purification of the epidermal growth factor receptor. Stoichiometry of binding and kinetics of self-phosphorylation.

1984 • 186 citations

In vitro phosphorylation of angiotensin analogs by tyrosyl protein kinases.

1983 • 186 citations

A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.

1987 • 186 citations

Purification and characterization of epidermal growth factor receptor/protein kinase from normal mouse liver.

1982 • 183 citations

Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization.

1986 • 167 citations

Characterization of the receptor for epidermal growth factor-urogastrone in human placenta membranes.

1980 • 126 citations

Growth factor control of epidermal growth factor receptor kinase activity via an intramolecular mechanism.

1988 • 98 citations

Purification of an active EGF receptor kinase with monoclonal antireceptor antibodies.

1985 • 98 citations

Antibody-induced dimerization activates the epidermal growth factor receptor tyrosine kinase

1991 • 96 citations

Intrapeptide autophosphorylation of the epidermal growth factor receptor: regulation of kinase catalytic function by receptor dimerization

1985 • 90 citations

Analysis of the reconstitution of oligomeric enzymes by crosslinking with glutaraldehyde: kinetics of reassociation of lactic dehydrogenase

1981 • 89 citations

Monomer of sodium and potassium ion activated adenosine triphosphatase displays complete enzymic function

1982 • 85 citations

Activation of the epidermal growth factor receptor tyrosine protein kinase in the absence of receptor oligomerization.

1988 • 84 citations

Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regions.

1988 • 81 citations

Structural analysis of the transmembrane domain of the epidermal growth factor receptor.

1991 • 80 citations

Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae.

1989 • 64 citations

Assembly of the catalytic trimers of aspartate transcarbamoylase from folded monomers.

1982 • 58 citations

High‐yield trapping of EGF‐induced receptor dimers by chemical cross‐linking ¹

1989 • 55 citations

Visualization of Epidermal Growth Factor (EGF) Receptor Aggregation in Plasma Membranes by Fluorescence Resonance Energy Transfer

1989 • 54 citations

Determination of the distribution of sodium and potassium ion activated adenosine triphosphatase among the various oligomers formed in solutions of nonionic detergents

1982 • 52 citations

Cross-linking of epidermal growth factor receptors in intact cells: detection of initial stages of receptor clustering and determination of molecular weight of high-affinity receptors

1986 • 45 citations

Regulation of kinase and intermolecular bonding in intact and truncated epidermal growth factor receptor.

1986 • 43 citations

The reconstitution of denatured phosphoglycerate mutase.

1983 • 42 citations

Evidence for active intermediates during the reconstitution of yeast phosphoglycerate mutase

1985 • 40 citations

Protein Kinase C Inhibition of the Epidermal Growth Factor Receptor Tyrosine Protein Kinase Activity is Independent of the Oligomeric State of the Receptor

1989 • 35 citations

Demonstration that lysine-501 of the .alpha. polypeptide of native sodium and potassium ion activated adenosine triphosphatase is located on its cytoplasmic surface

1987 • 34 citations

Characterization of plasma membranes from A431 cells, isolated by self-generating Percoll gradient: a rapid isolation procedure to obtain plasma membranes with functional epidermal growth factor receptors

1988 • 23 citations

Comparison of epidermal growth factor (EGF) receptor-receptor interactions in intact A431 cells and isolated plasma membranes. Large scale receptor micro-aggregation is not detected during EGF-stimulated early events

1991 • 21 citations