Kit Receptor Dimerization Is Driven by Bivalent Binding of Stem Cell Factor

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

1989 • 2,603 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule

1991 • 879 citations

Numbers of Receptor Sites from Scatchard Graphs: Facts and Fantasies

1982 • 683 citations

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

1994 • 665 citations

Rational Design of Potent Antagonists to the Human Growth Hormone Receptor

1992 • 633 citations

Regulation of signal transduction and signal diversity by receptor oligomerization

1994 • 485 citations

Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

1995 • 478 citations

Binding in the growth hormone receptor complex.

1996 • 434 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

Two EGF molecules contribute additively to stabilization of the EGFR dimer

1997 • 363 citations

Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor

1995 • 350 citations

Interaction between proteins localized in membranes.

1986 • 216 citations

The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction

1995 • 160 citations

Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor.

1992 • 151 citations

Glycosylated and unglycosylated recombinant-derived human stem cell factors are dimeric and have extensive regular secondary structure.

1991 • 110 citations

Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors

1994 • 94 citations

Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.

1993 • 83 citations

Interspecies molecular chimeras of kit help define the binding site of the stem cell factor.

1993 • 81 citations

Quantitative Characterization of Ligand Binding

1995 • 80 citations

Misuse of nonlinear scatchard plots

1989 • 76 citations

Human Stem Cell Factor Dimer Forms a Complex with Two Molecules of the Extracellular Domain of Its Receptor, Kit

1996 • 71 citations

Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor.

1993 • 66 citations

Interactions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and the NT-3.BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors.

1994 • 61 citations

A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses.

1992 • 57 citations

Purification and characterization of soluble forms of human and rat stem cell factor recombinantly expressed by Escherichia coli and by Chinese hamster ovary cells

1992 • 53 citations

Thermodynamic Studies of Tyrosyl-Phosphopeptide Binding to the SH2 Domain of p56lck

1994 • 53 citations

Quantitative characterization of ligand binding

1996 • 25 citations