Proteases and lung injury

The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.

1994 • 6,682 citations

The Acute Respiratory Distress Syndrome

1996 • 5,031 citations

The Acute Respiratory Distress Syndrome

2000 • 4,409 citations

Matrix metalloproteinases: effectors of development and normal physiology

2000 • 1,236 citations

Matrix metalloproteinases in neuroinflammation

2002 • 830 citations

The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis

2001 • 699 citations

Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups

1993 • 684 citations

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.

1986 • 576 citations

High Bronchoalveolar Levels of Tumor Necrosis Factor and Its Inhibitors, Interleukin-1, Interferon, and Elastase, in Patients with Adult Respiratory Distress Syndrome after Trauma, Shock, or Sepsis

1992 • 522 citations

Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer.

1998 • 430 citations

Neutrophil activation and acute lung injury

2001 • 427 citations

Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane.

1996 • 416 citations

Multiple NF-κB Enhancer Elements Regulate Cytokine Induction of the Human Inducible Nitric Oxide Synthase Gene

1998 • 408 citations

Impaired Immunity and Enhanced Resistance to Endotoxin in the Absence of Neutrophil Elastase and Cathepsin G

2000 • 384 citations

Leukocyte Elastase

2001 • 320 citations

Ischemia-reperfusion injury after lung transplantation increases risk of late bronchiolitis obliterans syndrome

2002 • 272 citations

Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation

1997 • 252 citations

Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS.

1996 • 235 citations

Neutrophil Elastase Induces MUC5AC Gene Expression in Airway Epithelium via a Pathway Involving Reactive Oxygen Species

2002 • 206 citations

A Randomized Controlled Trial of Filgrastim as an Adjunct to Antibiotics for Treatment of Hospitalized Patients with Community‐Acquired Pneumonia

1998 • 200 citations

Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation

2002 • 185 citations

Plasma elastase levels and the development of the adult respiratory distress syndrome.

1995 • 170 citations

The Pulmonary Vascular Sequestration of Neutrophils in Endotoxemia is Initiated by an Effect of Endotoxin on Neutrophil in the Rabbit

1987 • 161 citations

Delayed Neutrophil Elastase Inhibition Prevents Subsequent Progression of Acute Lung Injury Induced by Endotoxin Inhalation in Hamsters

2000 • 156 citations

Nitric oxide and its metabolites mediate ethanol-induced microtubule disruption and intestinal barrier dysfunction.

2000 • 151 citations

New perspectives on basic mechanisms in lung disease. 6. Proteinase imbalance: its role in lung disease.

1993 • 141 citations

The inhibitory complex of human alpha 1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant.

1988 • 139 citations

Adult respiratory distress syndrome in neutropenic patients

1986 • 136 citations

Physiology and Pathophysiology of Neutral Proteinases of Human Granulocytes

1984 • 134 citations

Neutrophil elastase and acute lung injury: Prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics

2002 • 130 citations

Generation of Biologically Active Angiostatin Kringle 1–3 by Activated Human Neutrophils

2002 • 130 citations

Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit

1994 • 120 citations

iNOS upregulation mediates oxidant-induced disruption of F-actin and barrier of intestinal monolayers

2001 • 109 citations

Inhibition of programmed cell death impairs in vitro vascular‐like structure formation and reduces in vivo angiogenesis

2002 • 105 citations

Neutrophil Elastase

2002 • 104 citations

Effects of Neutrophil Elastase Inhibitor on Bleomycin-Induced Pulmonary Fibrosis in Mice

1997 • 91 citations

Metalloproteinase Inhibition Prevents Acute Respiratory Distress Syndrome

2001 • 88 citations

Protection Against Acute Lung Injury by Intravenous or Intratracheal Pretreatment with EPI-HNE-4, a New Potent Neutrophil Elastase Inhibitor

2002 • 84 citations

Airways Inflammation and COPD

2002 • 81 citations

IL-2 Induces T Cell Adherence to Extracellular Matrix: Inhibition of Adherence and Migration by IL-2 Peptides Generated by Leukocyte Elastase

1998 • 79 citations

A Novel Oral Neutrophil Elastase Inhibitor (ONO-6818) Inhibits Human Neutrophil Elastase-induced Emphysema in Rats

2002 • 76 citations

The role of fibrin degradation products in neutrophil recruitment to the lung.

1996 • 75 citations

Integrin-linked Kinase Regulates Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in an NF-κB-dependent Manner

2002 • 75 citations

The Role of Metalloelastase in Immune Complex-Induced Acute Lung Injury

2001 • 74 citations

Inducible nitric oxide synthase mediates early epithelial repair of porcine ileum

2002 • 73 citations

Synergistic Cytokine-Induced Nitric Oxide Production in Human Alveolar Epithelial Cells

1999 • 72 citations

Adverse effects of neutrophils on the lung

1992 • 72 citations

THE ADULT RESPIRATORY DISTRESS SYNDROME: DEFINITION AND PROGNOSIS, PATHOGENESIS AND TREATMENT

1990 • 71 citations

Effects of a Neutrophil Elastase Inhibitor (ONO-5046) on Acute Pulmonary Injury Induced by Tumor Necrosis Factor Alpha (TNF α ) and Activated Neutrophils in Isolated Perfused Rabbit Lungs

1998 • 68 citations

Protective effects of an aptamer inhibitor of neutrophil elastase in lung inflammatory injury

1997 • 66 citations

Protective effects of ONO-5046·Na, a specific neutrophil elastase inhibitor, on postperfusion lung injury

1999 • 65 citations

Mechanisms of neutrophil damage to human alveolar extracellular matrix: The role of serine and metalloproteases

1992 • 64 citations

Human neutrophil elastase regulates the expression and secretion of elafin (elastase‐specific inhibitor) in type II alveolar epithelial cells

1999 • 62 citations

α1-Proteinase Inhibitor Therapy for the Prevention of Chronic Lung Disease of Prematurity: A Randomized, Controlled Trial

1998 • 61 citations

Elastase-released Epidermal Growth Factor Recruits Epidermal Growth Factor Receptor and Extracellular Signal-regulated Kinases to Down-regulate Tropoelastin mRNA in Lung Fibroblasts

2002 • 59 citations

Effects of protamine, heparinase, and hyaluronidase on endothelial permeability and surface charge

1987 • 58 citations

Neutrophils Mediate Acute Lung Injury in Rabbits: Role of Neutrophil Elastase

2000 • 57 citations

Regulation of cytokine secretion by cystic fibrosis airway epithelial cells

1993 • 52 citations

Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion

2001 • 50 citations

Administration of truncated secretory leukoprotease inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters.

1996 • 50 citations

Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster

2001 • 50 citations

Recombinant Human Monocyte/Neutrophil Elastase Inhibitor Protects Rat Lungs against Injury from Cystic Fibrosis Airway Secretions

1999 • 44 citations

Preventive effect of erythromycin on experimental bleomycin-induced acute lung injury in rats

1998 • 42 citations

Inhibition of Human Neutrophil Elastase-Induced Acute Lung Injury in Hamsters by Recombinant Human Pre-elafin (Trappin-2)

2002 • 40 citations

Regulation of Apoptosis During Mammary Involution by the p53 Tumor Suppressor Gene

2002 • 39 citations

Neutrophil elastase: alpha-1-proteinase inhibitor complex in serum and bronchoalveolar lavage fluid in patients with pulmonary fibrosis

1998 • 37 citations

The pre-term guinea-pig: a model for the study of neonatal lung disease

1991 • 33 citations

Inhibition of Neutrophil Elastase-lnduced lnterleukin-8 Gene Expression by Urinary Trypsin Inhibitor in Human Bronchial Epithelial Cells

1997 • 31 citations

The effects of a neutrophil elastase inhibitor (ONO-5046 · Na) and neutrophil depletion using a granulotrap (G-1) column on lung reperfusion injury in dogs

1999 • 28 citations

Neutrophil response to endotoxin in the adult respiratory distress syndrome: role of CD14.

1995 • 28 citations

Microvascular Permeability of the Non–Heart-Beating Rabbit Lung After Warm Ischemia and Reperfusion: Role of Neutrophil Elastase

1998 • 27 citations

Neutrophil Elastase Inhibitor, ONO-5046, Modulates Acid-induced Lung and Systemic Injury in Rabbits

1997 • 25 citations

Endotoxin-pretreated neutrophils increase pulmonary vascular permeability in dogs

1989 • 21 citations

Effects of lecithinized superoxide dismutase and a neutrophil elastase inhibitor (ONO-5046) on hyperoxic lung injury in rat

2000 • 17 citations

Triolein Increases Microvascular Permeability in Isolated Perfused Rabbit Lungs: Role of Neutrophils

2000 • 17 citations

ONO-5046 is a potent inhibitor of neutrophil elastase in human pleural effusion after lobectomy

1998 • 16 citations

EFFECT OF ONO-5046, A SPECIFIC NEUTROPHIL ELASTASE INHIBITOR, ON THE PHORBOL MYRISTATE ACETATE-INDUCED INJURY IN ISOLATED DOG LUNG

1999 • 16 citations

Pharmacological activities of TEI‐8362, a novel inhibitor of human neutrophil elastase

1999 • 14 citations

Role of inducible nitric-oxide synthase in regulation of whole-cell current in lung epithelial cells.

2000 • 10 citations

Inhibition of human neutrophil elastase and cathepsin G by a diphenyl disulfonic acid copolymer

1994 • 9 citations

Endotoxin-Induced Neutrophilic Alveolitis and Macrophage Chemotaxin Production in Sheep

1988 • 6 citations

Elastase activity in bronchoalveolar lavage fluid from oxygen-exposed,Pseudomonas-infected baboons

1991 • 6 citations

Compromised inhibition of human lung lavage cell elastases

1996 • 6 citations

Study on polymorphonucleocytal elastase-.ALPHA.1-protease inhibitor complex in bronchoalveolar lavage fluid(BALF).

1988 • 5 citations

Reducing neutrophil elastase-induced lung injury.

1999 • 3 citations