Regulation of Apoptosis During Mammary Involution by the p53 Tumor Suppressor Gene

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1998 • 906 citations

MDM2 — master regulator of the p53 tumor suppressor protein

2000 • 637 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

1996 • 538 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

1999 • 481 citations

Mammary Cell Number, Proliferation, and Apoptosis During a Bovine Lactation: Relation to Milk Production and Effect of bST

2001 • 415 citations

Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution

1997 • 371 citations

Cell death by apoptosis during involution of the lactating breast in mice and rats

1989 • 341 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Influence of Nutrition on Mammary Development in Pre- and Postpubertal Heifers

1982 • 273 citations

Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland.

1995 • 238 citations

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

1997 • 236 citations

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

1996 • 208 citations

Mammary involution in dairy animals.

1999 • 203 citations

Stromelysin-1 Regulates Adipogenesis during Mammary Gland Involution

2001 • 199 citations

Hormonal Control of Lactation

1942 • 199 citations

Cellular Turnover in the Mammary Gland Is Correlated with Systemic Levels of Progesterone and Not 17β-Estradiol During the Estrous Cycle1

2001 • 192 citations

Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.

1996 • 164 citations

Accelerated apoptosis in the Timp-3–deficient mammary gland

2001 • 164 citations

High body weight gain and reduced bovine mammary growth: physiological basis and implications for milk yield potential

2000 • 163 citations

Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice

1997 • 159 citations

Tumor suppressor p53: regulation and function

2000 • 153 citations

Expression of Autoactivated Stromelysin-1 in Mammary Glands of Transgenic Mice Leads to a Reactive Stroma During Early Development

1998 • 152 citations

MAMMARY DEVELOPMENT AND REGRESSION DURING LACTATION IN GOATS IN RELATION TO MILK SECRETION

1984 • 148 citations

Accelerated apoptosis in the Timp-3–deficient mammary gland

2001 • 144 citations

Bovine Mammary Lactoferrin: Implications from Messenger Ribonucleic Acid (mRNA) Sequence and Regulation Contrary to Other Milk Proteins

1993 • 133 citations

Bax and Bcl-xS are induced at the onset of apoptosis in involuting mammary epithelial cells

1996 • 121 citations

Feedback control of milk secretion from milk

1996 • 97 citations

Synergistic interaction of transforming growth factor alpha and c-myc in mouse mammary and salivary gland tumorigenesis.

1995 • 89 citations

Delayed involution of the mammary epithelium in BALB/c-p53null mice

1998 • 87 citations

Signal Transducer and Activator of Transcription 3 Activates CCAAT Enhancer-binding Protein δ Gene Transcription in G0Growth-arrested Mouse Mammary Epithelial Cells and in Involuting Mouse Mammary Gland

2000 • 76 citations

CCAAT/Enhancer-binding Protein δ Regulates Mammary Epithelial Cell G0 Growth Arrest and Apoptosis

1999 • 74 citations

Metabolic Adaptations in Mammary Gland During the Declining Phase of Lactation

1989 • 63 citations

Cytoplasmic sequestration and functional repression of p53 in the mammary epithelium is reversed by hormonal treatment.

2000 • 63 citations

Effects of milk yield on biological efficiency and profit of beef production from birth to slaughter.

1999 • 55 citations

Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development.

1994 • 55 citations

THE HORMONAL CONTROL OF LACTATION

1981 • 52 citations

Improving Sow Productivity through Management during Gestation, Lactation and after Weaning1

1986 • 50 citations

Regulation of a Physiological Apoptosis: Mouse Mammary Involution

1996 • 47 citations

A novel role for IRF-1 as a suppressor of apoptosis

2000 • 47 citations

Expression of a viral oncoprotein during mammary gland development alters cell fate and function: induction of p53-independent apoptosis is followed by impaired milk protein production in surviving cells.

1996 • 47 citations

Effects of genetic line and supplemental dietary fat on lactation performance of Duroc and Landrace sows

1992 • 41 citations

Insulin-like growth factor-I and insulin-like growth factor binding protein-3 inhibit involution of the mammary gland following lactation: Studies in transgenic mice

1995 • 39 citations

Direct and Correlated Responses to Selection for Milk Yield: Results and Conclusions of Regional Project NC-2, “Improvement of Dairy Cattle through Breeding, with Emphasis on Selection”

2000 • 33 citations

SV40 T/t-antigen induces premature mammary gland involution by apoptosis and selects for p53 missense mutation in mammary tumors

1998 • 33 citations

Proteinases, cell cycle regulation, and apoptosis during mammary gland involution (minireview)

2000 • 26 citations

Delay of dimethylbenz[a]anthracene‐induced mammary tumorigenesis in transgenic mice by apoptosis induced by an unusual mutant p53 protein

1995 • 26 citations

Understanding mammary gland development through the imbalanced expression of growth regulators

1996 • 25 citations

Expression of MDM2 during mammary tumorigenesis

1999 • 20 citations

National genetic improvement programs for dairy cattle in the United States2

1991 • 15 citations

Regulation of p53 and its targets during involution of the mammary gland.

1999 • 15 citations

Selection for Weaning Weight and Postweaning Gain in Hereford Cattle. III. Correlated Responses to Selection in Milk Yield, Preweaning and Postweaning Traits

1985 • 10 citations

Casein, Actin, and Tubulin Expression During Early Involution in Bovine and Murine Mammary Tissue

1992 • 8 citations