Back to search

Neutrophil elastase and acute lung injury: Prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics

Data up to Jan 2025

Published2002
Citations130
References38

Total Citations Per Year

Abstract

References (38)

The Acute Respiratory Distress Syndrome

1996 • 5,031 citations

The Acute Respiratory Distress Syndrome

2000 • 4,409 citations

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 831 citations

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

1998 • 686 citations

State of the Art

1983 • 655 citations

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.

1986 • 576 citations

Elastolytic Activity in Pulmonary Lavage Fluid from Patients with Adult Respiratory-Distress Syndrome

1981 • 528 citations

High Bronchoalveolar Levels of Tumor Necrosis Factor and Its Inhibitors, Interleukin-1, Interferon, and Elastase, in Patients with Adult Respiratory Distress Syndrome after Trauma, Shock, or Sepsis

1992 • 522 citations

Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment.

1981 • 446 citations

The cell biology of leukocyte-mediated proteolysis

1999 • 424 citations

Structure and function of thrombomodulin: a natural anticoagulant

1990 • 385 citations

ONO-5046, a novel inhibitor of human neutrophil elastase

1991 • 359 citations

Plasma thrombomodulin in health and diseases

1990 • 357 citations

Degradation of Outer Membrane Protein A in Escherichia coli Killing by Neutrophil Elastase

2000 • 345 citations

Leukocyte Elastase

2001 • 320 citations

Structure and function of thrombomodulin: a natural anticoagulant

1990 • 318 citations

Plasma thrombomodulin in health and diseases

1990 • 296 citations

Potential Mediator of Inflammation

1980 • 255 citations

Scientific perspectives on adult respiratory distress syndrome

1992 • 248 citations

Plasma elastase levels and the development of the adult respiratory distress syndrome.

1995 • 170 citations

Delayed Neutrophil Elastase Inhibition Prevents Subsequent Progression of Acute Lung Injury Induced by Endotoxin Inhalation in Hamsters

2000 • 156 citations

Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit

1994 • 120 citations

Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury

2000 • 107 citations

O2 metabolites and neutrophil elastase synergistically cause edematous injury in isolated rat lungs

1986 • 104 citations

Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury.

1996 • 104 citations

Xanthine oxidase mediates elastase-induced injury to isolated lungs and endothelium

1987 • 87 citations

Mechanism of Neutrophil-induced Xanthine Dehydrogenase to Xanthine Oxidase Conversion in Endothelial Cells: Evidence of a Role for Elastase

1992 • 76 citations

ONO-5046, an Elastase Inhibitor, Attenuates Endotoxin-Induced Acute Lung Injury in Rabbits

1997 • 70 citations

Effects of a Neutrophil Elastase Inhibitor (ONO-5046) on Acute Pulmonary Injury Induced by Tumor Necrosis Factor Alpha (TNF α ) and Activated Neutrophils in Isolated Perfused Rabbit Lungs

1998 • 68 citations

Protective effects of ONO-5046·Na, a specific neutrophil elastase inhibitor, on postperfusion lung injury

1999 • 65 citations

Effects of ONO-5046, a specific neutrophil elastase inhibitor, on endotoxin-induced lung injury in sheep

1994 • 65 citations

ONO-5046, an Elastase Inhibitor, Attenuates Endotoxin-Induced Acute Lung Injury in Rabbits

1997 • 52 citations

Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion

2001 • 50 citations

Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster

2001 • 50 citations

The Role of Neutrophil Elastase in Human Pulmonary Artery Endothelial Cell Injury

1997 • 35 citations

The effects of a neutrophil elastase inhibitor (ONO-5046 · Na) and neutrophil depletion using a granulotrap (G-1) column on lung reperfusion injury in dogs

1999 • 28 citations

Neutrophil Elastase Inhibitor, ONO-5046, Modulates Acid-induced Lung and Systemic Injury in Rabbits

1997 • 25 citations

EFFECT OF ONO-5046, A SPECIFIC NEUTROPHIL ELASTASE INHIBITOR, ON THE PHORBOL MYRISTATE ACETATE-INDUCED INJURY IN ISOLATED DOG LUNG

1999 • 16 citations

Cited By (0)

Loading...
Neutrophil elastase and acute lung injury: Prospects for sivelestat and other neutrophil… (2002) – Critical Care Medicine | Metascience Observatory Explorer