Neutrophil elastase and acute lung injury: Prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics
Data up to Jan 2025
Total Citations Per Year
Abstract
References (38)
The Acute Respiratory Distress Syndrome
1996 • 5,031 citations
The Acute Respiratory Distress Syndrome
2000 • 4,409 citations
Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.
1981 • 831 citations
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis
1998 • 686 citations
State of the Art
1983 • 655 citations
Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.
1986 • 576 citations
Elastolytic Activity in Pulmonary Lavage Fluid from Patients with Adult Respiratory-Distress Syndrome
1981 • 528 citations
High Bronchoalveolar Levels of Tumor Necrosis Factor and Its Inhibitors, Interleukin-1, Interferon, and Elastase, in Patients with Adult Respiratory Distress Syndrome after Trauma, Shock, or Sepsis
1992 • 522 citations
Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment.
1981 • 446 citations
The cell biology of leukocyte-mediated proteolysis
1999 • 424 citations
Structure and function of thrombomodulin: a natural anticoagulant
1990 • 385 citations
ONO-5046, a novel inhibitor of human neutrophil elastase
1991 • 359 citations
Plasma thrombomodulin in health and diseases
1990 • 357 citations
Degradation of Outer Membrane Protein A in Escherichia coli Killing by Neutrophil Elastase
2000 • 345 citations
Leukocyte Elastase
2001 • 320 citations
Structure and function of thrombomodulin: a natural anticoagulant
1990 • 318 citations
Plasma thrombomodulin in health and diseases
1990 • 296 citations
Potential Mediator of Inflammation
1980 • 255 citations
Scientific perspectives on adult respiratory distress syndrome
1992 • 248 citations
Plasma elastase levels and the development of the adult respiratory distress syndrome.
1995 • 170 citations
Delayed Neutrophil Elastase Inhibition Prevents Subsequent Progression of Acute Lung Injury Induced by Endotoxin Inhalation in Hamsters
2000 • 156 citations
Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit
1994 • 120 citations
Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury
2000 • 107 citations
O2 metabolites and neutrophil elastase synergistically cause edematous injury in isolated rat lungs
1986 • 104 citations
Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury.
1996 • 104 citations
Xanthine oxidase mediates elastase-induced injury to isolated lungs and endothelium
1987 • 87 citations
Mechanism of Neutrophil-induced Xanthine Dehydrogenase to Xanthine Oxidase Conversion in Endothelial Cells: Evidence of a Role for Elastase
1992 • 76 citations
ONO-5046, an Elastase Inhibitor, Attenuates Endotoxin-Induced Acute Lung Injury in Rabbits
1997 • 70 citations
Effects of a Neutrophil Elastase Inhibitor (ONO-5046) on Acute Pulmonary Injury Induced by Tumor Necrosis Factor Alpha (TNF α ) and Activated Neutrophils in Isolated Perfused Rabbit Lungs
1998 • 68 citations
Protective effects of ONO-5046·Na, a specific neutrophil elastase inhibitor, on postperfusion lung injury
1999 • 65 citations
Effects of ONO-5046, a specific neutrophil elastase inhibitor, on endotoxin-induced lung injury in sheep
1994 • 65 citations
ONO-5046, an Elastase Inhibitor, Attenuates Endotoxin-Induced Acute Lung Injury in Rabbits
1997 • 52 citations
Effects of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion
2001 • 50 citations
Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster
2001 • 50 citations
The Role of Neutrophil Elastase in Human Pulmonary Artery Endothelial Cell Injury
1997 • 35 citations
The effects of a neutrophil elastase inhibitor (ONO-5046 · Na) and neutrophil depletion using a granulotrap (G-1) column on lung reperfusion injury in dogs
1999 • 28 citations
Neutrophil Elastase Inhibitor, ONO-5046, Modulates Acid-induced Lung and Systemic Injury in Rabbits
1997 • 25 citations
EFFECT OF ONO-5046, A SPECIFIC NEUTROPHIL ELASTASE INHIBITOR, ON THE PHORBOL MYRISTATE ACETATE-INDUCED INJURY IN ISOLATED DOG LUNG
1999 • 16 citations