Neutrophil activation and acute lung injury

The Acute Respiratory Distress Syndrome

1996 • 5,031 citations

The Acute Respiratory Distress Syndrome

2000 • 4,409 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

1996 • 1,217 citations

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 • 1,209 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

1998 • 819 citations

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

1998 • 686 citations

Mechanics of Stimulated Neutrophils: Cell Stiffening Induces Retention in Capillaries

1989 • 612 citations

Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins.

1989 • 577 citations

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

1997 • 549 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

1997 • 434 citations

Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms.

1995 • 428 citations

Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane.

1996 • 416 citations

Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome.

1994 • 407 citations

The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation

2002 • 394 citations

Impaired Immunity and Enhanced Resistance to Endotoxin in the Absence of Neutrophil Elastase and Cathepsin G

2000 • 384 citations

Adult Respiratory Distress Syndrome in Patients with Severe Neutropenia

1986 • 381 citations

Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability.

1989 • 342 citations

p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulation.

1998 • 336 citations

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

1997 • 314 citations

Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.

1997 • 311 citations

Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia

1999 • 284 citations

Role of Inducible Nitric Oxide Synthase in Endotoxin-induced Acute Lung Injury

1998 • 277 citations

p38 Mitogen-Activated Protein Kinase Activation Is Required for Human Neutrophil Function Triggered by TNF-α or FMLP Stimulation

1998 • 269 citations

Granulocyte-Macrophage Colony-Stimulating Factor Delays Neutrophil Constitutive Apoptosis Through Phosphoinositide 3-Kinase and Extracellular Signal-Regulated Kinase Pathways

2000 • 262 citations

Role of p38 Mitogen-Activated Protein Kinase in a Murine Model of Pulmonary Inflammation

2000 • 249 citations

Elevation of Intracellular cAMP Inhibits RhoA Activation and Integrin-dependent Leukocyte Adhesion Induced by Chemoattractants

1997 • 205 citations

A Randomized Controlled Trial of Filgrastim as an Adjunct to Antibiotics for Treatment of Hospitalized Patients with Community‐Acquired Pneumonia

1998 • 200 citations

Chemotactic Peptide N-formyl-Met-Leu-Phe Activation of p38 Mitogen-activated Protein Kinase (MAPK) and MAPK-activated Protein Kinase-2 in Human Neutrophils

1997 • 184 citations

Modulation of neutrophil apoptosis by granulocyte colony-stimulating factor and granulocyte/macrophage colony-stimulating factor during the course of acute respiratory distress syndrome

2000 • 180 citations

Physiological neutrophil sequestration in the lung: visual evidence for localization in capillaries

1987 • 178 citations

Phosphoinositide 3-Kinase-dependent and -independent Activation of the Small GTPase Rac2 in Human Neutrophils

1999 • 172 citations

Selectins and neutrophil traffic: margination and Streptococcus pneumoniae-induced emigration in murine lungs.

1996 • 172 citations

Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr

1998 • 164 citations

Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation.

1988 • 161 citations

Delayed Neutrophil Elastase Inhibition Prevents Subsequent Progression of Acute Lung Injury Induced by Endotoxin Inhalation in Hamsters

2000 • 156 citations

Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice.

1997 • 154 citations

Induction of Tyrosine Phosphorylation and Na+/H+Exchanger Activation during Shrinkage of Human Neutrophils

1997 • 154 citations

Integrin-mediated signaling in human neutrophil functioning

1999 • 149 citations

Integrin signal transduction in myeloid leukocytes

1999 • 134 citations

Role of p38-Mitogen-Activated Protein Kinase in Spontaneous Apoptosis of Human Neutrophils

1999 • 132 citations

Matrix Metalloproteinase Inhibitor Prevents Acute Lung Injury After Cardiopulmonary Bypass

1999 • 129 citations

Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation.

1993 • 114 citations

CD11/CD18-Dependent and -Independent Neutrophil Emigration in the Lungs

2000 • 104 citations

Signaling Functions of L-Selectin in Neutrophils: Alterations in the Cytoskeleton and Colocalization with CD18

1999 • 103 citations

A role for β ₂ integrins (CD11/CD18) in the regulation of cytokine gene expression of polymorphonuclear neutrophils during the inflammatory response

1999 • 102 citations

L- and P-Selectin and CD11/CD18 in Intracapillary Neutrophil Sequestration in Rabbit Lungs

1999 • 99 citations

Mediation of ARDS by Leukocytes

1986 • 90 citations

Effect of the NADPH oxidase inhibitor apocynin on septic lung injury in guinea pigs.

1994 • 86 citations

Adhesion Molecules and Cellular Biomechanical Changes in Acute Lung Injury

1999 • 84 citations

Neutrophil deformability in patients with sepsis, septic shock, and adult respiratory distress syndrome

2000 • 82 citations

Role of<scp>l</scp>-Selectin in Leukocyte Sequestration in Lung Capillaries in a Rabbit Model of Endotoxemia

2000 • 79 citations

Stimulation of Human Neutrophils by Chemotactic Factors Is Associated with the Activation of Phosphatidylinositol 3-Kinase γ

2000 • 76 citations

TRANSIENT LEUCOPENIA ASSOCIATED WITH ADULT RESPIRATORY DISTRESS SYNDROME

1984 • 74 citations

Phosphatidylinositol 3-Kinase Mediates Chemoattractant-Stimulated, CD11b/CD18-Dependent Cell-Cell Adhesion of Human Neutrophils: Evidence for an ERK-Independent Pathway

1998 • 70 citations

VLA-4 (α4β1) engagement defines a novel activation pathway for β2 integrin–dependent leukocyte adhesion involving the urokinase receptor

2000 • 69 citations

Antibody-induced engagement of β2 integrins in human neutrophils causes a rapid redistribution of cytoskeletal proteins, Src-family tyrosine kinases, and p72syk that precedes de novo actin polymerization

1998 • 66 citations

Inhibition of neutrophil oxidative burst and granule secretion by Wortmannin: Potential role of MAP kinase and renaturable kinases

1997 • 65 citations

Preservation of complement-induced lung injury in mice with deficiency of NADPH oxidase.

1996 • 62 citations

Antibody to E- and L-Selectin Does Not Prevent Lung Injury or Mortality in Septic Baboons

1998 • 55 citations

Cytokine‐mediated cPLA₂ phosphorylation is regulated by multiple MAPK family members

2000 • 53 citations

β₂-Integrin Blockade Driven by E-Selectin Promoter Prevents Neutrophil Sequestration and Lung Injury in Mice

2000 • 48 citations

Leukotoxin and its diol induce neutrophil chemotaxis through signal transduction different from that of fMLP

2000 • 38 citations

Neutrophil β2-Integrin Upregulation Is Blocked by a p38 MAP Kinase Inhibitor

2000 • 36 citations

Regulation of Neutrophil Activation in Acute Lung Injury

1999 • 28 citations

Adult respiratory distress syndrome in neutropenic leukemia patients

1989 • 25 citations

An Intracellular Signaling Pathway Linking Lipopolysaccharide Stimulation to Cellular Responses of the Human Neutrophil

1999 • 18 citations