A role for dietary fat in leptin receptor, OB-Rb, function

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

The Leptin Receptor

1997 • 1,300 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

Hypothalamic CART is a new anorectic peptide regulated by leptin

1998 • 1,283 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

1997 • 907 citations

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

1996 • 879 citations

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

2000 • 873 citations

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice

1996 • 873 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

Activation of Downstream Signals by the Long Form of the Leptin Receptor

2000 • 800 citations

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues

1997 • 771 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.

1989 • 711 citations

The Role of SOCS-3 in Leptin Signaling and Leptin Resistance

1999 • 640 citations

Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily

1990 • 614 citations

Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice

2000 • 556 citations

A novel family of growth factor receptors: A common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor β-chain

1989 • 551 citations

Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin

1998 • 518 citations

Lipid regulation of cell membrane structure and function

1989 • 492 citations

Obesity and the Hypothalamus: Novel Peptides for New Pathways

1998 • 448 citations

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.

1990 • 430 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Cloning of an Interleukin-3 Receptor Gene: a Member of a Distinct Receptor Gene Family

1990 • 417 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

CART peptides in the central control of feeding and interactions with neuropeptide Y

1998 • 379 citations

Interactions Between the Melanocortin System and Leptin in Control of Sympathetic Nerve Traffic

1999 • 367 citations

Sympathetic and Cardiorenal Actions of Leptin

1997 • 354 citations

The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

1997 • 315 citations

Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect

1992 • 288 citations

Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat

1997 • 262 citations

Obesity, A Disorder Of Nutrient Partitioning: The MONA LISA Hypothesis

1991 • 243 citations

A Short Form of Leptin Receptor Performs Signal Transduction

1997 • 211 citations

Leptin Receptor Long-form Splice-variant Protein Expression in Neuron Cell Bodies of the Brain and Co-localization with Neuropeptide Y mRNA in the Arcuate Nucleus

1999 • 204 citations

Inhibition of Food Response to Intracerebroventricular Injection of Leptin Is Attenuated in Rats With Diet-Induced Obesity

1997 • 200 citations

Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain

2000 • 193 citations

Leptin Induces Mitogen-activated Protein Kinase- dependent Proliferation of C3H10T1/2 Cells

1997 • 187 citations

Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action.

1999 • 176 citations

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

1999 • 172 citations

Leptin Sensitive Neurons in the Hypothalamus

1999 • 172 citations

Hypothalamic obesity

1981 • 169 citations

Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding

1997 • 162 citations

Central Administration of Cocaine-Amphetamine-Regulated Transcript Activates Hypothalamic Neuroendocrine Neurons in the Rat

2000 • 160 citations

Localization of Leptin Binding Domain in the Leptin Receptor

1998 • 149 citations

Dynamic modulation of mitochondrial inner-membrane lipids in rat heart by dietary fat

1981 • 141 citations

Leptin Receptor Signal Transduction: OBRa and OBRb offaType

1998 • 140 citations

Cocaine- and amphetamine-regulated transcript in the rat vagus nerve: A putative mediator of cholecystokinin-induced satiety

1999 • 140 citations

Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.

1996 • 129 citations

OB protein binds specifically to the choroid plexus of mice and rats.

1996 • 124 citations

Lipids, Membrane Receptors, and Enzymes: Effects of Dietary Fatty Acids

1990 • 122 citations

Transcription Factor STAT3 in Leptin Target Neurons of the Rat Hypothalamus

1998 • 114 citations

Dietary fat type and energy restriction interactively influence plasma leptin concentration in rats

1998 • 112 citations

Up‐Regulation of Blood‐Brain Barrier Short‐Form Leptin Receptor Gene Products in Rats Fed a High Fat Diet

1998 • 96 citations

Relationship between fatty acid accretion, membrane composition, and biologic functions

1994 • 90 citations

Effect of (n-3) polyunsaturated fatty acids on cytokine production and their biologic function.

1996 • 83 citations

Homeostatic control of membrane fatty acid composition in the rat after dietary lipid treatment

1984 • 78 citations

The Long Terminal Repeat of an Endogenous Retrovirus Induces Alternative Splicing and Encodes an Additional Carboxy-Terminal Sequence in the Human Leptin Receptor

1999 • 76 citations

Obesity Results as a Consequence of Glucocorticoid Induced Leptin Resistance

1996 • 60 citations

Hypothalamic and genetic obesity: an appraisal of the autonomic hypothesis and the endocrine hypothesis.

1984 • 58 citations

Effects of Leptin on Melanin-Concentrating Hormone Expression in the Brain of Lean and Obese Lep<sup>ob</sup>/Lep<sup>ob</sup> Mice

1999 • 58 citations

The influence of membrane fluidity, TNF receptor binding, cAMP production and GTPase activity on macrophage cytokine production in rats fed a variety of fat diets.

1997 • 55 citations

Influence of dietary fats on c-Fos-like immunoreactivity in mouse hypothalamus

1999 • 50 citations

Leptin, its receptor and obesity.

1996 • 48 citations

Activation of Mitogen-Activated Protein Kinase by Norepinephrine in Brown Adipocytes from Rats¹

1997 • 45 citations

Upregulation of leptin receptor mRNA expression in obese mouse brain

1997 • 43 citations

Distribution of the transcription factor Signal Transducer and Activator of Transcription 3 in the rat central nervous system and dorsal root ganglia

2000 • 39 citations

Homology Modeling of Human Leptin/ Leptin Receptor Complex

2000 • 37 citations

Neuropeptides Responding to Leptin

2009 • 29 citations

Hypothalamic Neuropeptide Y and Its Neuroendocrine Regulation by Leptin

1999 • 15 citations

Leptin Regulation of Proopiomelanocortin

1999 • 12 citations

Effect of membrane phospholipid composition and fluidity on rat liver plasma membrane tyrosine kinase activity

1993 • 9 citations