Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

Interleukin-6: An Overview

1990 • 1,910 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

Cytokine receptor signalling

1995 • 1,242 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1993 • 554 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.

1991 • 499 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

1995 • 425 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1995 • 346 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Interleukin-3 signals through multiple isoforms of Stat5.

1995 • 327 citations

Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.

1993 • 319 citations

Lack of Interferon γ Receptor β Chain and the Prevention of Interferon γ Signaling in T_H1 Cells

1995 • 292 citations

Ligand-Induced Autoregulation of IFN-γ Receptor β Chain Expression in T Helper Cell Subsets

1995 • 219 citations

STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.

1995 • 211 citations

Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.

1993 • 193 citations

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

1996 • 188 citations

The signalling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements.

1994 • 181 citations

The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells.

1994 • 151 citations

JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes.

1994 • 136 citations

Cytokines and STATs: How can signals achieve specificity?

1995 • 132 citations

Two Novel Protein-Tyrosine Kinases, Each with a Second Phosphotransferase-Related Catalytic Domain, Define a New Class of Protein Kinase

1991 • 118 citations

lnterleukin-2 transcriptional block by multifunctional Ca2+/ calmodulin kinase

1994 • 115 citations

Role of SH-PTP2, a Protein-Tyrosine Phosphatase with Src Homology 2 Domains, in Insulin-Stimulated Ras Activation

1994 • 108 citations

Activation of Protein Kinase A Inhibits Interferon Induction of the Jak/Stat Pathway in U266 Cells

1996 • 72 citations

Regulation of the balance of cytokine production and the signal transducer and activator of transcription (STAT) transcription factor activity by cytokines and inflammatory synovial fluids.

1995 • 65 citations

Syp Associates with gp130 and Janus Kinase 2 in Response to Interleukin-11 in 3T3-L1 Mouse Preadipocytes

1995 • 63 citations

Activation of monocyte effector genes and STAT family transcription factors by inflammatory synovial fluid is independent of interferon γ.

1995 • 56 citations

Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells.

1995 • 56 citations

Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation.

1995 • 51 citations

The Signalling Pathways of Interleukin-6 and Gamma Interferon Converge by the Activation of Different Transcription Factors Which Bind to Common Responsive DNA Elements

1994 • 49 citations

IgG immune complexes inhibit IFN-gamma-induced transcription of the Fc gamma RI gene in human monocytes by preventing the tyrosine phosphorylation of the p91 (Stat1) transcription factor.

1995 • 49 citations

Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells.

1995 • 48 citations

Repression of class II major histocompatibility complex genes by cyclic AMP is mediated by conserved promoter elements.

1991 • 27 citations