Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

1996 • 1,505 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

1996 • 879 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

A role for leptin and its cognate receptor in hematopoiesis

1996 • 478 citations

Leptin Receptor (OB-R) Signaling

1997 • 290 citations

Phenotype of fatty Due to Gln269Pro Mutation in the Leptin Receptor (Lepr)

1996 • 289 citations

Threading analysis suggests that the obese gene product may be a helical cytokine

1995 • 261 citations

Evidence that Na+/H+ exchanger isoforms NHE1 and NHE3 exist as stable dimers in membranes with a high degree of specificity for homodimers.

1994 • 176 citations

Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus.

1996 • 176 citations

Phenotype-Linked Amino Acid Alteration in Leptin Receptor cDNA from Zucker Fatty(fa/fa)Rat

1996 • 140 citations

OB protein binds specifically to the choroid plexus of mice and rats.

1996 • 124 citations

Autoradiographic Localization of Leptin Binding in the Choroid Plexus ofob/obanddb/dbMice

1996 • 102 citations

Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice.

1996 • 100 citations

Recombinant soluble human interleukin-5 (hIL-5) receptor molecules. Cross-linking and stoichiometry of binding to IL-5.

1993 • 92 citations

Leptin receptor (OB‐R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130

1997 • 82 citations

Dimerization of the Extracellular Domain of Granulocyte-Colony Stimulating Factor Receptor by Ligand Binding: A Monovalent Ligand Induces 2:2 Complexes

1996 • 61 citations

Evidence for the ligand‐induced conversion from a dimer to a tetramer of the granulocyte colony‐stimulating factor receptor

1994 • 30 citations